Minimally invasive procedure for diagnosis and treatment of vallecular cysts in children: review of 156 cases

Wang, Guixiang; Zhao, Jing; Wang, Hua; Li, Hongbin; Zhang, Jie; Ni, Xin

doi:10.1007/s00405-020-06163-9

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…It can inhibit 229E, OC43, SARS-CoV, and MERS-CoV replication in vitro, and treatment with remdesivir ameliorates SARS and COVID-19 ( 35 – 37 ). Therefore, remdesivir was granted emergency use approval by the US Food and Drug Administration for COVID-19 treatment, based on recently published results ( 38 – 40 ). However, whether remdesivir reduces 229E and NL63 replication in vivo remains unclear.…”

Section: Resultsmentioning

confidence: 99%

Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2

Liu

Chen

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Human coronavirus 229E (HCoV-229E) and NL63 (HCoV-NL63) are endemic causes of upper respiratory infections such as the “common cold” but may occasionally cause severe lower respiratory tract disease in the elderly and immunocompromised patients. There are no approved antiviral drugs or vaccines for these common cold coronaviruses (CCCoV). The recent emergence of COVID-19 and the possible cross-reactive antibody and T cell responses between these CCCoV and SARS-CoV-2 emphasize the need to develop experimental animal models for CCCoV. Mice are an ideal experimental animal model for such studies, but are resistant to HCoV-229E and HCoV-NL63 infections. Here, we generated 229E and NL63 mouse models by exogenous delivery of their receptors, human hAPN and hACE2 using replication-deficient adenoviruses (Ad5-hAPN and Ad5-hACE2), respectively. Ad5-hAPN- and Ad5-hACE2-sensitized IFNAR −/− and STAT1 −/− mice developed pneumonia characterized by inflammatory cell infiltration with virus clearance occurring 7 d post infection. Ad5-hAPN- and Ad5-hACE2-sensitized mice generated virus-specific T cells and neutralizing antibodies after 229E or NL63 infection, respectively. Remdesivir and a vaccine candidate targeting spike protein of 229E and NL63 accelerated viral clearance of virus in these mice. 229E- and NL63-infected mice were partially protected from SARS-CoV-2 infection, likely mediated by cross-reactive T cell responses. Ad5-hAPN- and Ad5-hACE2-transduced mice are useful for studying pathogenesis and immune responses induced by HCoV-229E and HCoV-NL63 infections and for validation of broadly protective vaccines, antibodies, and therapeutics against human respiratory coronaviruses including SARS-CoV-2.

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Section: Resultsmentioning

confidence: 99%

Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2

Liu

Chen

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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“…It is recommended to deroof the cyst under direct microlaryngoscopy (marsupialization) or through resection using an endoscopic CO 2 laser. These techniques allow excellent depth perception, perfect surgical precision, and good control of postoperative edema and pain besides being suitable for all age groups [ 16 - 18 ]. In this case study, resection of the vallecular cyst through cold and hot electrocautery techniques had no adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Successful Management of a Symptomatic Vallecular Cyst in an Adult: A Case Report

Alharbi,

Alahmari,

Al Hamoud

et al. 2023

Cureus

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In adults, vallecular cysts are usually asymptomatic but can present with respiratory and gastrointestinal manifestations. A 45-year-old man presented with a four-month progressive history of dysphonia, dysphagia to solid, snoring, choking, apnea, and aspiration. On examination, the patient was vitally stable with no remarkable local and physical examination. Flexible nasoendoscopy, computer tomography, and subsequent micro-laryngoscopy revealed a non-pulsating, non-congested 3 x 2 cm cyst obscuring vocal cord visualization. The cyst was removed completely by cold and hot techniques and was sent for biopsy. This case report presents the successful management of a symptomatic vallecular cyst through electrocautery.

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“…Due to its location, a laryngeal mass may pose a diagnostic and surgical dilemma; thus, imaging of the lesion is essential. A retrospective study done by Wang GX et al in the pediatric population concluded that FNPLS combined with USG of the neck is sufficient to diagnose and exclude ectopic thyroid gland as it is commonly congenital and benign [11]. However, differential diagnoses of midline laryngeal mass in adult populations can be benign or malignant, such as lingual thyroid cysts, thyroglossal cysts, mucous retention cysts, dermoid cysts, salivary gland neoplasm, lymphangioma, hemangioma, benign lipoma, and liposarcoma [12].…”

Section: Discussionmentioning

confidence: 99%

Large Vallecula Epiglottica Lipoma: A Rare but Fatal Cause of Dysphagia

Sharudin¹,

Thangavelu²,

Roslim³

et al. 2022

Cureus

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Lipoma is a benign mesenchymal tumor with 13% occurrence in the head and neck region. Despite being the commonest type of tumor, it only accounts for 0.6% of the upper aerodigestive tract. We report a case of a 41-year-old gentleman who presented with progressively worsening dysphagia and a muffled voice. A flexible nasopharyngeal endoscope showed a solitary well-lobulated pedunculated cystic-looking mass occupying the oropharynx arising from the vallecular space and lingual surface of the epiglottis with a partially seen mobile posterior vocal cord. CT of the neck showed a single lesion with fat attenuation in the right vallecula and right lateral lingual epiglottis. The patient underwent endoscopic surgical excision and fully recovered post-operatively. Although rare, lipoma must be considered one of the differential diagnoses of midline laryngeal mass. Therefore, prompt excision needs to be performed to prevent a catastrophic outcome.

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Minimally invasive procedure for diagnosis and treatment of vallecular cysts in children: review of 156 cases

Cited by 8 publications

References 18 publications

Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2

Mouse models susceptible to HCoV-229E and HCoV-NL63 and cross protection from challenge with SARS-CoV-2

Successful Management of a Symptomatic Vallecular Cyst in an Adult: A Case Report

Large Vallecula Epiglottica Lipoma: A Rare but Fatal Cause of Dysphagia

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