Abstract:OBJECTIVEThe objective of this study was to compare anterior cervical discectomy and fusion (ACDF) and minimally invasive posterior cervical foraminotomy (MI-PCF) with tubes for the treatment of cervical radiculopathy in terms of the 1) overall revision proportion, 2) index and adjacent level revision rates, and 3) functional outcome scores.METHODSThe authors retrospectively reviewed the records of consecu… Show more
“…Instability issues after partial facetectomy during PF may lead problems that require fusion, in general fusion after PF have rates of up to 5%. Recent retrospective studies of minimal invasive PF with over 1000 cases shown that a good level of decompression is achieved, i.e., to same or better NDI in comparison to ACDF [22][23][24][25][26][27][28][29][30][31][32].…”
Section: Background and Rationale {6a}mentioning
confidence: 99%
“…The preserved motion may lead to restenosis as the degeneration continues with the risk of secondary surgery on the index level [34]. PF will lead to clinical success in 64-96% with a reoperation incidence of 4-7% in retrospective cohort studies [22][23][24][25][26][27][28][29][30][31][32][35][36][37].…”
Background
Cervical radiculopathy is the most common disease in the cervical spine, affecting patients around 50–55 year of age. An operative treatment is common clinical praxis when non-operative treatment fails. The controversy is in the choice of operative treatment, conducting either anterior cervical decompression and fusion or posterior foraminotomy. The study objective is to evaluate short- and long-term outcome of anterior cervical decompression and fusion (ACDF) and posterior foraminotomy (PF)
Methods
A multicenter prospective randomized controlled trial with 1:1 randomization, ACDF vs. PF including 110 patients. The primary aim is to evaluate if PF is non-inferior to ACDF using a non-inferiority design with ACDF as “active control.” The neck disability index (NDI) is the primary outcome measure, and duration of follow-up is 2 years.
Discussion
Due to absence of high level of evidence, the authors believe that a RCT will improve the evidence for using the different surgical treatments for cervical radiculopathy and strengthen current surgical treatment recommendation.
Trial registration
ClinicalTrials.gov NCT04177849. Registered on November 26, 2019
“…Instability issues after partial facetectomy during PF may lead problems that require fusion, in general fusion after PF have rates of up to 5%. Recent retrospective studies of minimal invasive PF with over 1000 cases shown that a good level of decompression is achieved, i.e., to same or better NDI in comparison to ACDF [22][23][24][25][26][27][28][29][30][31][32].…”
Section: Background and Rationale {6a}mentioning
confidence: 99%
“…The preserved motion may lead to restenosis as the degeneration continues with the risk of secondary surgery on the index level [34]. PF will lead to clinical success in 64-96% with a reoperation incidence of 4-7% in retrospective cohort studies [22][23][24][25][26][27][28][29][30][31][32][35][36][37].…”
Background
Cervical radiculopathy is the most common disease in the cervical spine, affecting patients around 50–55 year of age. An operative treatment is common clinical praxis when non-operative treatment fails. The controversy is in the choice of operative treatment, conducting either anterior cervical decompression and fusion or posterior foraminotomy. The study objective is to evaluate short- and long-term outcome of anterior cervical decompression and fusion (ACDF) and posterior foraminotomy (PF)
Methods
A multicenter prospective randomized controlled trial with 1:1 randomization, ACDF vs. PF including 110 patients. The primary aim is to evaluate if PF is non-inferior to ACDF using a non-inferiority design with ACDF as “active control.” The neck disability index (NDI) is the primary outcome measure, and duration of follow-up is 2 years.
Discussion
Due to absence of high level of evidence, the authors believe that a RCT will improve the evidence for using the different surgical treatments for cervical radiculopathy and strengthen current surgical treatment recommendation.
Trial registration
ClinicalTrials.gov NCT04177849. Registered on November 26, 2019
“…Based on a solid body of evidence, MI-PCF is a successful alternative surgery to reduce problems such as false joints, adjacent segment diseases, and anterior-related complications. MI-PCF does not necessitate the patient giving up a cervical spine motion segment, and it has a lower complication rate, a lower cost, and a faster return to movement ( 50 , 51 ). Based on the findings of this study, PCF, similar to other interventions, produced satisfactory results, with no statistical difference in postoperative success rates, post-operative complication rates, or postoperative working status, which is consistent with previous study findings ( 52 ).…”
BackgroundTraditionally paired meta-analysis revealed inconsistencies in the safety and effectiveness of surgical interventions. We conducted a network meta-analysis to assess various treatments' clinical efficacy and safety for pure cervical radiculopathy.MethodsThe Embase, PubMed, and Cochrane Library databases were searched for randomized controlled trials (RCTs) comparing different treatment options for patients with pure cervical radiculopathy from inception until October 23, 2021. The primary outcomes were postoperative success rates, postoperative complication rates, and postoperative reoperation rates. The pooled data were subjected to a random-effects consistency model. The protocol was published in PROSPERO (CRD42021284819).ResultsThis study included 23 RCTs (n = 1,844) that evaluated various treatments for patients with pure cervical radiculopathy. There were no statistical differences between treatments in the consistency model in terms of major clinical effectiveness and safety outcomes. Postoperative success rates were higher for anterior cervical foraminotomy (ACF: probability 38%), posterior cervical foraminotomy (PCF: 24%), and anterior cervical discectomy with fusion and additional plating (ACDFP: 21%). Postoperative complication rates ranked from high to low as follows: cervical disc replacement (CDR: probability 32%), physiotherapy (25%), ACF (25%). Autologous bone graft (ABG) had better relief from arm pain (probability 71%) and neck disability (71%). Among the seven surgical interventions with a statistical difference, anterior cervical discectomy with allograft bone graft plus plating (ABGP) had the shortest surgery time.ConclusionsAccording to current results, all surgical interventions can achieve satisfactory results, and there are no statistically significant differences. As a result, based on their strengths and patient-related factors, surgeons can exercise discretion in determining the appropriate surgical intervention for pure cervical radiculopathy.Systematic Review Registration: CRD42021284819.
“…Overall six studies were included in quantitative synthesis including four studies that directly compare MIS-PCF to ACDF, one study that directly compares MIS-PCF to TDA, and one study that compares MIS-PCF to both ACDF and TDA. [53][54][55][56][57][58] A flow chart of study inclusion and exclusion is shown in Figure 1.…”
Study Design Systematic review and meta-analysis. Objectives Patients with lateral cervical disc and foraminal pathology can be treated with anterior and posterior approaches including anterior cervical discectomy and fusion(ACDF), cervical total disc arthroplasty(TDA), and minimally invasive posterior cervical foraminotomy(MIS-PCF). Although MIS-PCF may have some advantages over the anterior approaches, few comparative studies and meta-analyses have been done to assess superiority. Methods This study includes a systematic review of the literature and meta-analysis of studies directly comparing minimally invasive posterior cervical foraminotomy to either anterior cervical discectomy and fusion or cervical total disc arthroplasty. Results In comparing patients undergoing ACDF and MIS-PCF, operative time ranged from 68 to 97.8 minutes in the ACDF group compared to 28 to 93.9 minutes in the MIS-PCF group. Mean postoperative length of stay ranged from 33.84 to 112.8 hours in the ACDF group compared to 13.68 to 83.6 hours in the MIS-PCF group. The total complication rates were 3.72% in the ACDF group and 3.73% in the MIS-PCF group. A random-effects model meta-analysis was carried out which failed to show a statistically significant difference in the complication rate between the two procedures(OR .91; 95% CI 0.13, 6.43; P = .92, I2 = 59%). The total reoperation rate was 3.5% in the ACDF group and 5.4% in the MIS-PCF group. A random-effects model meta-analysis was carried out which failed to show a statistically significant difference in the reoperation rate between the two procedures(OR .66; 95% CI 0.33, 1.33; P = .25, I2 = 0). In comparing patients undergoing TDA and MIS-PCF, operative time ranged from 90.3 to 106.7 minutes in the TDA group compared to 77.4 to 93.9 minutes in the MIS-PCF group. Mean postoperative length of stay ranged from 103.2 to 165.6 hours in the TDA group and 93.6 to 98.4 hours in the MIS-PCF group. The complication rate ranged from 23.5 to 28.6% in the TDA group and 0 to 14.3% in the MIS-PCF group. The overall reoperation rates were 2.6% in the TDA group and 10.2% in the MIS-PCF group. Conclusions There is no clear superiority between MIS-PCF and ACDF/TDA in terms of operative time, postoperative length of stay, or rate of complications/reoperations. Further studies with increased follow-up intervals >48 months, and higher sample sizes are necessary to determine the true superiority of MIS-PCF and anterior neck approaches in treatment of lateral disc and foraminal pathology.
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