Minimally Invasive Photodynamic Therapy (PDT) for Ablation of Experimental Rat Glioma

Hirschberg, Henry; Spetalen, Signe; Carper, Stephen W.; Hole, P; Tillung, Terje; Madsen, Steen J.

doi:10.1055/s-2006-932216

Cited by 17 publications

(7 citation statements)

References 28 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, PDT is most promising for eradication of superficial tumors, including early stage or premalignant disease, and residual tumor cells left behind after surgical resection that are often responsible for recurrence [38,39]. Moreover, in certain scenarios, light delivery into deeper tissues or larger tumors can be achieved via interstitial PDT incorporating intratumoral placement of fiber optic light delivery devices [38,40,41].…”

Section: Light Wavelength and Penetration Depthmentioning

confidence: 99%

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

et al. 2019

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a two-step treatment involving the local administration of a photosensitive agent followed by its activation at a specific light wavelength. PDT has been approved by the United States Food and Drug Administration (FDA) for the treatment of premalignant and malignant diseases, such as actinic keratoses, Barrett's esophagus, esophageal cancers, and endobronchial non-small cell lung cancers, as well as for the treatment of choroidal neovascularization. In oncology, clinical trials are currently underway to demonstrate PDT efficacy against a number of malignancies that include glioblastoma (GBM) and other brain tumors. Both photosensitizers and photosensitizing precursors have been used for PDT. Photofrin and Visudyne are photosensitizers with FDA approval for PDT of high-grade dysplasia in Barrett's esophagus and subfoveal choroidal neovascularization, respectively. 5-aminolevulinic acid (5-ALA), an intermediate in the heme synthesis pathway, is a photosensitizing precursor with FDA approval for PDT of actinic keratosis and fluorescence-guided visualization of malignant tissue during glioma surgery. In this review, the history and current use of 5-ALA PDT for the treatment of high-grade gliomas (HGGs) will be discussed.

show abstract

Section: Light Wavelength and Penetration Depthmentioning

confidence: 99%

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

et al. 2019

View full text Add to dashboard Cite

show abstract

“…F98 and BT 4 C cells were injected stereotactically into the brains of Fischer rats, as previously described. 22 Briefly, anaesthetized rats were fixed in a stereotactic frame. The skin was incised and a 1.0-mm burr hole was made at the following coordinates: 1 mm posterior to the bregma, 2 mm to the right of the midline, and at a depth of 2 mm.…”

Section: Tumor Cell Injectionmentioning

confidence: 99%

Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats

et al. 2018

View full text Add to dashboard Cite

Immunotherapy of brain tumors involves the stimulation of an antitumor immune response. This type of therapy can be targeted specifically to tumor cells thus sparing surrounding normal brain. Due to the presence of the blood-brain barrier, the brain is relatively isolated from the systemic circulation and, as such, the initiation of significant immune responses is more limited than other types of cancers. The purpose of this study was to show that the efficacy of tumor primed antigen presenting macrophage (MaF98) vaccines can be increased by: (1) photodynamic therapy (PDT) of the priming tumor cells and (2) intracranial injection of allogeneic glioma cells directly into the tumor site. Experiments were conducted in an in vivo brain tumor development model using Fischer rats and F98 (syngeneic) and BT4C (allogeneic) glioma cells. The results showed that immunization with Ma (acting as antigen-presenting cells), primed with PDT-treated tumor cells (MaF98), significantly slowed but did not prevent the growth of F98-induced tumors in the brain. Complete suppression of tumor development was obtained via MaF98 inoculation combined with direct intracranial injection of allogeneic glioma cells. No deleterious effects were noted in any of the animals during the 14-day observation period.

show abstract

“…[1][2][3][4] For example, both surgery and radiation may damage adjacent normal tissues. Surgery needs a certain period of time for wound recovery, and chemotherapy is a highly cytotoxic treatment that affects tissues and organs.…”

Section: Introductionmentioning

confidence: 99%

Effective near-infrared photodynamic therapy assisted by upconversion nanoparticles conjugated with photosensitizers

Dou¹,

Teng²,

Ye³

et al. 2015

IJN

View full text Add to dashboard Cite

A drug model photosensitizer–conjugated upconversion nanoparticles nanocomplex was explored for application in near-infrared photodynamic therapy. As near-infrared penetrates deeper into the tissue, the model is useful for the application of photodynamic therapy in deeper tissue. The nanocomplex that was synthesized had low polydispersity, and the upconversion nanoparticle was covalently conjugated with the photosensitizer. The robust bond could prevent the undesired premature release of photosensitizer and also enhance the singlet-oxygen generation. Singlet-oxygen generation rate from this nanocomplex was evaluated in solution. The photodynamic therapy effect was assessed with MCF-7 cells in two different methods, 3-(4,5-dimethylth-iazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead assay. The assay results showed that promising efficacy (>90%) can be achieved with a low concentration (50 μg mL −1 ) of this nanocomplex and mild dosage (7 mW cm −2 ) of near-infrared laser treatment.

show abstract

Minimally Invasive Photodynamic Therapy (PDT) for Ablation of Experimental Rat Glioma

Cited by 17 publications

References 28 publications

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas

Limiting glioma development by photodynamic therapy-generated macrophage vaccine and allo-stimulation: an in vivo histological study in rats

Effective near-infrared photodynamic therapy assisted by upconversion nanoparticles conjugated with photosensitizers

Contact Info

Product

Resources

About