Background: Minimal invasive cardiac surgery is cosmetically attractive to the patient; however, debate still exists regarding its safety and the effective exposure during the technique. We present our local experience in video assisted minimally invasive mitral valve replacement, for the surgically challenging rheumatic valve disease, still endemic among Egyptian population. Methods: This prospective single center study was conducted on 20 rheumatic heart patients, presenting with severe mitral regurgitation (8 patients; 40%), severe mitral stenosis (8 patients; 40%) or combined lesion (4 patients; 20%). The patients underwent video assisted minimally invasive mitral valve replacement, through a right mini-thoracotomy via: an infra-mammary incision (13 patients; 65%), periareolar incision (4; 20%) or limited right anterolateral mini-thoracotomy (3 patients; 15%). Early postoperative quality of life was evaluated using SF 36 questionnaire. Results: Mean length of skin incision was (6.60 ± 1.35 cm). Mean durations of operation, cardiopulmonary bypass, and cross-clamp times were: 4.32 ± 1.08, 2.85 ± 0.75 and 1.78 ± 0.47 hrs; respectively. The mean amount of blood loss was 398.50 ± 245.79 ml, with two patients (10%) requiring re-exploration. At discharge, all patients had normal prosthetic mitral valve function with no regurgitation by echocardiography. Four patients (20%) had atrial fibrillation postoperatively. Total durations of ICU stay and hospital stays were: 2.35 ± 1.14 and 6.45 ± 1.43 days, and 90% of patients return to daily work and full activity within 4 weeks. Conclusions: Video assisted minimally invasive mitral valve surgery in rheumatic valve disease has low surgical trauma, blood loss, and pain, which translates into a short hospital stay and rapid return to normal activities.