Minimally invasive lymphatic mapping using fluorescently labeled vitamin B12

Structures of the b‐ and d‐Acid Derivatives of Vitamin B12 and Their Complexes with [M(CO)3]+ (M = 99mTc, Re)

“…Grissom et al coupled fluorescing molecules by a Co-C bond to B 12 and used this derivative for lymphatic mapping. [13,14] We bound several rhenium, technetium and platinum complexes to the cyano group and could confirm the authenticity of the products by X-ray structure analysis. [15,16] The preferred site for derivatisation are the three propionamide and the two acetamide groups bound to the periphery of the corrin ring, which is, like the backloop, bound to three propionamide and two acetamide groups.…”

Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings

“…1,5–7 In connection with our studies on aryl isoxazole amides (AIMs) 8–9 we have reported lead compounds, which possess (1) useful antitumor activity and (2) photophysical properties, which are of potential diagnostic use as ‘tumor paint’. 10 …”

Crystallography of vitamin B12 proteins

“…This role started with the landmark crystal structure of vitamin B 12 or cyanocobalamin (CNCbl) [4,5], which allowed the upsurge of vitamin B 12 chemistry, up to the recent crystal structure of several B 12 -dependent enzymes, which has provoked an enormous increase in work on vitamin B 12 enzymology [6,7]. Finally, the recent X-ray structure of transcobalamin (TC) [8] has furnished the structural basis for designing appropriate Cbl-based bioconjugates for imaging of tumours as well as targeted and selected delivery of anti-tumour agents to malignant cells [9,10]. CNCbl belongs to a group of strictly related compounds called cobalamins (Fig.…”