2012
DOI: 10.2147/ijn.s37575
|View full text |Cite
|
Sign up to set email alerts
|

Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease

Abstract: Myocardial infarction (MI) is characterized by heart-wall thinning, myocyte slippage, and ventricular dilation. The injury to the heart-wall muscle after MI is permanent, as after an abundant cell loss the myocardial tissue lacks the intrinsic capability to regenerate. New therapeutics are required for functional improvement and regeneration of the infarcted myocardium, to overcome harmful diagnosis of patients with heart failure, and to overcome the shortage of heart donors. In the past few years, myocardial … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
24
0

Year Published

2013
2013
2021
2021

Publication Types

Select...
5
2
1

Relationship

1
7

Authors

Journals

citations
Cited by 38 publications
(24 citation statements)
references
References 239 publications
(264 reference statements)
0
24
0
Order By: Relevance
“…On the other hand, pure natural materials suffer from uncontrolled compositions and lack suitable mechanical properties. Thus, in order to overcome a deficit of pure materials, synthetic polymers are frequently used in combination with natural polymers or small peptide sequences to promote cell-biomaterial interactions while the structural support is maintained for tissue regeneration (Krupnick et al , 2002, Ravichandran et al , 2012a. For example, collagen or gelatin blended with polyurethane (Stankus et al , 2004), nanofibers of poly(caprolactone) (PCL) (Shin et al , 2004), poly(L-lactide acid) (PLLA) (Krupnick, Kreisel, 2002) or PGS (Ravichandran et al , 2011) improved cellular adhesion and behavior.…”
Section: Classification Of Applied Biomaterials In Myocardial Tissue mentioning
confidence: 99%
“…On the other hand, pure natural materials suffer from uncontrolled compositions and lack suitable mechanical properties. Thus, in order to overcome a deficit of pure materials, synthetic polymers are frequently used in combination with natural polymers or small peptide sequences to promote cell-biomaterial interactions while the structural support is maintained for tissue regeneration (Krupnick et al , 2002, Ravichandran et al , 2012a. For example, collagen or gelatin blended with polyurethane (Stankus et al , 2004), nanofibers of poly(caprolactone) (PCL) (Shin et al , 2004), poly(L-lactide acid) (PLLA) (Krupnick, Kreisel, 2002) or PGS (Ravichandran et al , 2011) improved cellular adhesion and behavior.…”
Section: Classification Of Applied Biomaterials In Myocardial Tissue mentioning
confidence: 99%
“…Nevertheless, they have not yet reached the cell viability and proliferation rates observed with natural biomaterials. Consequently, synthetic polymers are used in combination with natural compound or small peptide sequences in order to promote cell-biomaterial interactions for tissue regeneration [33].…”
Section: Biomaterials In Cardiac Repairmentioning
confidence: 99%
“…On the other hand, NFs need to be attached to the pericardium, so a more invasive administration technique is required. However, it is highly desirable that biomaterials should provide satisfactory mechanical support to the infarcted heart, in order to favor functional recovery of the damaged organ [33]. In this sense, NFs have proved to be able to contribute more efficiently to the heart's mechanical properties than other DDS.…”
Section: Challenges Aheadmentioning
confidence: 99%
“…Among the potential delivery methods for cardiomyocyte transplantation, direct injection and the use of cardiac tissue patches are two of the most commonly studied approaches. Direct injection of either pluripotent cells or mature cardiomyocytes has been reviewed in detail and assessed by a number of groups as a surgically less‐invasive means for physically introducing regenerative cells at a diseased site . However, direct injection reduces the viability of injected cells, with only 1–32% surviving after transplantation .…”
Section: Biomimetic Materials Design For Cardiac Tissue Regenerationmentioning
confidence: 99%