Minimally invasive breast carcinoma staging using lymphatic mapping with radiolabeled dextran

Offodile, Regina; Hoh, Carl K.; Barsky, Sanford H.; Nelson, Scott D.; Elashoff, Robert M.; Eilber, Frederick R.; Economou, James S.; Nguyen, Mai

doi:10.1002/(sici)1097-0142(19980501)82:9<1704::aid-cncr17>3.0.co;2-8

Cited by 119 publications

(33 citation statements)

References 15 publications

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“…Sentinel node detection rates have not varied with lesion size in other series that have specifically analyzed size as a determinant of success. 8,12,14,16 Most lesions were early invasive carcinomas, as in most other series, and the axilla was negative to palpation. In the case of palpable nodes, however, which is more likely to occur with larger lesions, tumorfilled lymph nodes causing obstruction of the distal lymphatics would change lymphatic flow, possibly invalidating the sentinel node concept.…”

Section: Discussionsupporting

confidence: 51%

“…15 However, there are other studies using radiocolloid without image guidance that have shown little difference in sentinel node identification rates. 16,17 It is not known whether successful mapping using blue dye after surgical excision is also partly related to better lymphatic absorption and flow compared with that of a radiopharmaceutical.…”

Section: Discussionmentioning

confidence: 99%

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Biopsy Method and Excision Volume Do Not Affect Success Rate of Subsequent Sentinel Lymph Node Dissection in Breast Cancer

et al. 2000

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SLND has a high success rate in breast cancer patients regardless of the biopsy method or the excision volume removed before SLND. In addition, the interval from biopsy to SLND, tumor size, and tumor location have no effect on the success rate of SLND, even in this series which included patients operated on before the technique was adequately defined. Patients with breast cancers located in any quadrant and diagnosed either with a needle or excisional biopsy could be evaluated for trials of SLND.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Biopsy Method and Excision Volume Do Not Affect Success Rate of Subsequent Sentinel Lymph Node Dissection in Breast Cancer

et al. 2000

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“…19 We therefore used Salinhes, a product of similar constitution that is used more frequently than dextran. Salinhes consists of starch with a mean molecular weight of 70 000, and is used clinically as a substitute for blood plasma.…”

Section: Discussionmentioning

confidence: 99%

New method of sentinel node detection using a combination of contrast-enhanced ultrasound and dye guidance: an animal study

et al. 2006

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“…99m Tc-labelled dextran was first used in lymphoscintigraphy by Henze et al in 1982 [10]. More recently, in 1998, Ofodile et al [11] demonstrated its usefulness in SLN mapping in breast carcinoma, achieving successful identification of the SLN in 98% of cases. In their study the sensitivity of SLN biopsy in predicting axillary node status was 100%, with no false-negative results.…”

Section: Discussionmentioning

confidence: 99%

Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping

Barros

Cardoso

Sheng

et al. 2002

European Journal of Nuclear Medicine and Molecular Imaging

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The authors report their experience with a new strategy for radioguided breast surgery that combines radioguided occult lesion localisation (ROLL) and sentinel lymph node (SLN) mapping. The study population comprised 38 women with non-palpable breast lesions suspicious for breast cancer (BI-RADS 4-5). On the day before surgery, 0.2 ml solution containing particles of dextran labelled with approximately 15 MBq of technetium-99m was injected under stereotaxic guidance by mammography. All patients underwent open surgical biopsy guided by gamma probe, radiographic control of the surgical specimen and frozen section analysis. The rate of confirmation of lesion removal was 100% and the rate of simultaneous SLN mapping was 97.3% (37/38). Eleven cases of infiltrating carcinoma and eight of ductal carcinoma in situ (DCIS) were diagnosed intraoperatively. In the first eight invasive lesions, the SLN was biopsied and complete axillary lymph node dissection was performed; in the three other invasive lesions and in two aggressive cases of DCIS, only the SLN was dissected. The intraoperative results of SLN analysis and the definitive histopathological examinations of the SLN were always negative. It is concluded that ROLL and SLN can be employed simultaneously when dextran is used as a tracer; this technique allows frozen section diagnosis and intra-operative node analysis, and has many advantages over the conventional two-step procedure.

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Minimally invasive breast carcinoma staging using lymphatic mapping with radiolabeled dextran

Cited by 119 publications

References 15 publications

Biopsy Method and Excision Volume Do Not Affect Success Rate of Subsequent Sentinel Lymph Node Dissection in Breast Cancer

Biopsy Method and Excision Volume Do Not Affect Success Rate of Subsequent Sentinel Lymph Node Dissection in Breast Cancer

New method of sentinel node detection using a combination of contrast-enhanced ultrasound and dye guidance: an animal study

Radioguided localisation of non-palpable breast lesions and simultaneous sentinel lymph node mapping

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