Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity

Shakibfar, Saeed; Graff, Claus; Kanters, Jørgen K.; Nielsen, Jimmi; Schmidt, Samuel; Struijk, Johannes

doi:10.1111/anec.12413

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Interestingly, our recent work has proposed the minimal T-wave representation by making T-wave independent of QT duration and thus much less dependent on heart rate. The results of analyzing the minimal T-wave shape showed that it could identify normal from abnormal repolarization significantly better compared to heart rate corrected QT interval (QTc) and most of the prolongation occurred in the ascending segment of the T-wave whereas T-peak to T-end was less sensitive relatively after d,l-sotalol [38]. Also, studies of the effects of some IKr blockers on multiple sub-intervals of the QT interval showed that hERG potassium channel block equally affects the whole T-wave duration, early and late repolarization (Tj to Tend and Tpe intervals) whereas additional inward current block (calcium or late sodium) preferentially shortens early repolarization [39,40].…”

Section: Discussionmentioning

confidence: 99%

Association between Tpeak-Tend interval and QT prolongation: A study of sertindole and sotalol

Shakibfar¹,

Struijk²,

Kanters³

et al. 2018

Pharm Drug Dev Ther

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The electrocardiographic interval between the peak and the end of the T-wave (Tpe) is believed to be an arrhythmic risk marker. However, there are also a number of reports that are inconsistent with the usefulness of Tpe for identifying abnormal repolarization. This study was designed to investigate how the Tpe prolongation is correlated to a prolonged QT interval, induced by I Kr -blockers. The study included two data sets. A first group of 21 healthy subjects received 160 mg and 320 mg doses of d,l-sotalol. The second group, of 40 patients with schizophrenia, was switched to 16 mg sertindole treatment. The Fridericia corrected QT prolongations (QTcF) and the mean Tpe changes (∆Tpe) were: d,l-sotalol 160 mg: ∆QTcF=29 ms & ∆Tpe=4.7 ms, 320 mg: ∆QTcF=51 ms & ∆Tpe=6.2 ms, sertindole 16 mg: ∆QTcF=17 ms & ∆Tpe=8.5 ms. There were low correlations (r) between ∆QTcF and ∆Tpe in both d,l-sotalol groups and sertindole group.Given the lack of linear relationship between Tpe and QT in response to potential torsadogenic drugs, this study raises doubt about the usefulness of Tpe as a biomarker for repolarization changes and torsadogenic potential in drug safety studies.

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Section: Discussionmentioning

confidence: 99%

Association between Tpeak-Tend interval and QT prolongation: A study of sertindole and sotalol

Shakibfar¹,

Struijk²,

Kanters³

et al. 2018

Pharm Drug Dev Ther

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“…These two state-of-the-art methods also indirectly aid in uncovering dependencies. In connection with such a statement, the same case is applied These components are integrated to produce Semitics of TS through both intra-coupling and inter-coupling relationships within a set of behaviors [56]. The Behavior Constraint Indicator module formalizes natural language descriptions of behaviors into logical formulas.…”

Section: Rq4: Dependencies Impact Of the T Wavementioning

confidence: 99%

Methodological identification of anomalies episodes in ECG streams: a systematic mapping study

Iqbal,

Almakki,

Usman

et al. 2024

BMC Med Res Methodol

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An electrocardiogram is a medical examination tool for measuring different patterns of heart blood flow circle either in the form of usual or non-invasive patterns. These patterns are useful for the identification of morbidity condition of the heart especially in certain conditions of heart abnormality and arrhythmia. Myocardial infarction (MI) is one of them that happened due to sudden blockage of blood by the cause of malfunction of heart. In electrocardiography (ECG) intensity of MI is highlighted on the basis of unusual patterns of T wave changes. Various studies have contributed for MI through T wave’s classification, but more to the point of T wave has always attracted the ECG researchers. Methodology. This Study is primarily designed for proposing the combination of latest methods that are worked for the solutions of pre-defined research questions. Such solutions are designed in the form of the systematic review process (SLR) by following the Kitchen ham guidance. The literature survey is a two phase’s process, at first phase collect the articles that were published in IEEE Xplore, Scopus, science direct and Springer from 2008 to 2023. It consist of steps; the first level is executed by filtrating the articles on the basis of keyword phase of title and abstract filter. Similarly, at two level the manuscripts are scanned through filter of eligibility criteria of articles selection. The last level belongs to the quality assessment of articles, in such level articles are rectified through evaluation of domain experts. Results. Finally, the selected articles are addressed with research questions and briefly discuss these selected state-of-the-art methods that are worked for the T wave classification. These address units behave as solutions to research problems that are highlighted in the form of research questions. Conclusion and future directions. During the survey process for these solutions, we got some critical observations in the form of gaps that reflected the other directions for researchers. In which feature engineering, different dependencies of ECG features and dimensional reduction of ECG for the better ECG analysis are reflection of future directions.

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“…R-on-T, which may lead to torsade de pointes type of arrhythmia 23 . Another important research direction concerning repolarization is drug arrhythmogenicity assesment 24 .…”

Section: Introductionmentioning

confidence: 99%

Synchronous recording of magnetocardiographic and electrocardiographic signals

Pęczalski,

Sobiech,

Buchner

et al. 2023

Preprint

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We present a system for simultaneous recording of the electrocardiogram and the magnetocardiogram. The measurement system contained of printed carbon electrodes and SERF magnetometer. The use of this system confirms that the position of the end of the magnetic T wave extends further than the electric T wave, which is an important indicator for the diagnosis of cardiological patients and for drug arrhythmogenicity. We analyze this phenomenon in depth, and demonstrate, that it originates from the fundamental difference between electric and magnetic measurements. The measured value is always bipolar since the electric measurements require two electrodes. We demonstrate how the dual electric and magnetic measuring system adds a new information to the commonly used electrocardiographic diagnosis. The ECG should be interpreted as the spatial asymmetry of the electric cardiac potential, and not as the potential itself. The results seem to prove, that the relation between the magnetic and the electric imaging of neural activities may be broadly applied for the benefit of medical diagnosis in cardiology and many other fields, where the neural activity is measured. This is a pilot study which requires further confirmation at the clinical level.

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Minimal T-wave representation and its use in the assessment of drug arrhythmogenicity

Abstract: The minimal T-wave representation can potentially be used as a new tool to identify normal from abnormal repolarization in drug safety studies.

Cited by 5 publications

References 35 publications

Association between Tpeak-Tend interval and QT prolongation: A study of sertindole and sotalol

Association between Tpeak-Tend interval and QT prolongation: A study of sertindole and sotalol

Methodological identification of anomalies episodes in ECG streams: a systematic mapping study

Synchronous recording of magnetocardiographic and electrocardiographic signals

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