Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility

Abstract

Minimal stimulation appears to be an effective protocol in cases of unexplained infertility undergoing intrauterine insemination. Reduced cost and minimal monitoring is appealing to patients and the clinician.

Mild/minimal stimulation for in vitro fertilization: an old idea that needs to be revisited

“…Simultaneously, improvements in IVF methodology also aided in improved implantation rates, leading to more high-order multiple pregnancies and a higher incidence of OHSS. These negative effects led many to question the continued need for aggressive stimulation and to encourage the reintroduction of mild stimulation protocols (10)(11)(12)(13)(14).…”

Follicular recruitment is reduced in minimal stimulation for controlled ovarian hyperstimulation using purified human menopausal gonadotropin compared with follicle-stimulating hormone

“…A minstim protocol for intrauterine insemination (IUI) has been described, with clomiphene citrate (CC) given on cycle days 3 through 7 and 150 IU of hMG on cycle day 9 (2). This protocol has pregnancy rates that are similar to conventional hMG cycles (16.2%-20.8%) but at a reduced cost and patient burden due to the decrease in number of injections and visits for monitoring (2,3). However, the multiple pregnancy rate is also similar to conventional hMG cycles (2).…”

A Minimal Stimulation Protocol With Simplified Monitoring for Superovulation and Intrauterine Insemination

“…The present study was conducted 10 Monitoring of outcome Pregnancy was tested 4~5 days after the missed period followed by ultrasound examination 2 weeks later for the detection of gestational sac and cardiac activity.…”