Minimal persistent inflammation is present at mucosal level in patients with asymptomatic rhinitis and mite allergy

Ciprandi, Giorgio; Buscaglia, S; Pesce, Giampaola; Pronzato, Caterina; Ricca, V.; Parmiani, S.; Bagnasco, Marcello; Canonica, Giorgio Walter

doi:10.1016/s0091-6749(95)70235-0

Cited by 227 publications

(156 citation statements)

References 35 publications

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“…This inflammation may be similar in nature to that found in a process called 'minimal persistent inflammation' (MPI) that has been demonstrated in both mite-induced and pollen-induced rhinitis 8 and asymptomatic allergic subjects. 28 Although the URTS questionnaire has been used successfully in the past to identify URTS 30 it is possible that a more sensitive questionnaire is required to identify self-reported symptoms/manifestations of minimal airway inflammation.…”

Section: Discussionsupporting

confidence: 65%

Non-allergic activation of eosinophils after strenuous endurance exercise

McKune

Smith

Semple

et al. 2004

S. Afr. j. sports med.

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Section: Discussionsupporting

confidence: 65%

Non-allergic activation of eosinophils after strenuous endurance exercise

McKune

Smith

Semple

et al. 2004

S. Afr. j. sports med.

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“…This fact confirms the previous outcome: mite allergy is characterized by the well-known concept of minimal persistent inflammation. 18 The continuous exposure to causal allergen induces persistence of inflammation that may favor complications. In addition, it has been evidenced that birch allergy is also characterized by this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Impact of allergic rhinitis on asthma: effects on bronchodilation testing

Ciprandi

Cirillo²,

Pistorio

et al. 2008

Annals of Allergy, Asthma & Immunology

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Background: A remarkable relationship exists between the upper and lower airways. Bronchial obstruction is a paramount feature of asthma, and its reversibility is considered a main step in asthma diagnosis.Objective: To investigate the degree of bronchodilation and possible risk factors related to it in patients with moderate-severe persistent allergic rhinitis alone.Methods: A total of 375 patients with moderate-severe persistent allergic rhinitis and 115 controls were prospectively and consecutively evaluated by means of clinical examination, skin prick testing, spirometry, and bronchodilation testing.Results: Patients with rhinitis showed a significant increase in forced expiratory volume in 1 second (FEV 1 ) after bronchodilation testing compared with basal values and levels in controls (P Ͻ .001). Two-thirds of the rhinitic patients had reversibility (Ն12% basal levels). Patients with reversibility had lower FEV 1 levels, longer rhinitis duration, and mite and tree allergies.Conclusions: This study highlights the close link between the upper and lower airways and the relevance of performing bronchodilation testing in patients with moderate-severe persistent allergic rhinitis.

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“…grass pollen allergy in Southern California and Florida (60) or Parietaria pollen allergy in the Mediterranean area (61)]; • symptoms of perennial allergy may not always be present all year round. This is particularly the case for a large number of patients allergic to house dust mites (HDM) suffering only from mild or moderate/severe IAR (62)(63)(64)(65). This is also the case in the Mediterranean area where levels of HDM allergen are low in the summer (66);…”

Section: Intermittent (Iar) and Persistent Allergic Rhinitis (Per)mentioning

confidence: 99%