Minimal Invasive Transcaruncular Optic Canal Decompression for Traumatic Optic Neuropathy

Vaitheeswaran, Krishna; Kaur, Preetinder; Garg, Shalini

doi:10.3109/01676830.2014.950282

Cited by 8 publications

(9 citation statements)

References 5 publications

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“…However, clinical treatment is far more complicated. The current clinical protective methods primarily suggested surgical optic canal decompression ( Kong et al, 2011 ; Vaitheeswaran et al, 2014 ). Besides surgical method, noninvasive methods have shed some lights on the treatment of axon injury and neuronal protection.…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein

Zhou

Liu

Chen

et al. 2018

Front. Cell. Neurosci.

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Background: Low-intensity pulsed ultrasound (LIPUS) has been used in clinical studies. But little is known about its effects on the central nervous system (CNS), or its mechanism of action. Retinal ganglion cells (RGCs) are CNS neuronal cells that can be utilized as a classic model system to evaluate outcomes of LIPUS protection from external trauma-induced retinal injury. In this study, we aim to: (1) determine the pulse energy and the capability of LIPUS in RGC viability, (2) ascertain the protective role of LIPUS in optic nerve (ON) crush-induced retinal injury, and 3) explore the cellular mechanisms of RGC apoptosis prevention by LIPUS.Methods: An ON crush model was set up to induce RGC death. LIPUS was used to treat mice eyes daily, and the retina samples were dissected for immunostaining and Western blot. The expression of yes-associated protein (YAP) and apoptosis-related proteins was detected by immunostaining and Western blot in vitro and in vivo. Apoptosis of RGCs was evaluated by TUNEL staining, the survival of RGCs and retained axons were labeled by Fluoro-gold and Tuj1 antibody, respectively. Rotenone was used to set up an in vitro cellular degenerative model and siYAP was used to interfering the expression of YAP to detect the LIPUS protective function.Results: LIPUS protected RGC from loss and apoptosis in vivo and in vitro. The ratio of cleaved/pro-caspase3 also decreased significantly under LIPUS treatment. As a cellular mechanical sensor, YAP expression increased and YAP translocated to nucleus in LIPUS stimulation group, however, phospho-YAP was found to be decreased. When YAP was inhibited, the LIPUS could not protect RGC from caspase3-dependent apoptosis.Conclusion: LIPUS prevented RGCs from apoptosis in an ON crush model and in vitro cellular degenerative model, which indicates a potential treatment for further traumatic ON injury. The mechanism of protection is dependent on YAP activation and correlated with caspase-3 signaling.

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Section: Introductionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein

Zhou

Liu

Chen

et al. 2018

Front. Cell. Neurosci.

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“… 22 Multimodal imaging can be utilized for the diagnosis and evaluation of eye injuries. 23 Ultrasound is the initial imaging modality, with classic examinations revealing a dilated, funnel-shaped vitreous hemorrhage extending from the optic nerve head to the vitreous. A wide optic nerve pattern with retrobulbar echolucent areas indicates a retrobulbar hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Optic Nerve Avulsion: Pattern and Etiologies at a Tertiary Eye Care Center in Saudi Arabia: An 8-Year Retrospective Study

Al Amry,

AlHijji,

Elkhamary

et al. 2023

OPTH

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Purpose Optic nerve avulsion (ONA) is a rare but serious presentation of ocular trauma. This study investigates the presenting characteristics and etiologies of all cases of ONA over an 8-year-period at a tertiary eye care center in the Middle East. Methods The medical records of patients diagnosed with ONA at an Ophthalmic Emergency Department between November 2014 and November 2022 were analyzed in this retrospective cohort study. Data were collected on patient age, sex, affected eye, cause of injury and imaging studies. The best-corrected visual acuity (BCVA) at presentation and at the last follow-up visit, and the duration of follow-up were documented. Results The study sample was comprised of 44 eyes of 43 patients with ONA with median age of 16.5 (9.3–26.8) years ranging from 2 years old to 70 years old. There were (35;79.5%) males and (9; 20.5%) females. Most cases presented with an affected left eye (27; 61.4%) followed by the right eye (16; 36.4%) and only one patient (2.3%) had bilateral ONA. The most common cause of trauma resulting in ONA was a metallic object (8;18.2%). This study demonstrates the value of multi-sequence Magnetic resonance imaging (MRI) in the setting of unexplained vision loss when other modalities are inadequate or inconclusive. Conclusion Ophthalmic morbidity resulting from ONA can be devastating. Metallic object injuries were the most prevalent cause of ONA. The presence of associated media opacities challenges the initial diagnosis of ONA. In the vast majority of cases, the vision ended as no light perception (NLP), indicating permanent vision impairment.

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“…All of our cases received drug therapy, 3 cases whose visual acuity improved did not receive operation, 2 cases refused operation for personal reasons, 24 cases whose visual acuity did not change after drug therapy received surgical treatment. In terms of surgical treatments, optic canal decompression can directly clean bone chips and haematomas, relieve optic nerve compression due to ischaemia, and decrease or minimize secondary nerve injuries, thus providing direct treatment ( 16 ). Consequently, we performed surgical treatment for most of the patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical treatment of traumatic optic neuropathy in children: Summary of 29 cases

et al. 2018

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Clinical features and treatments for traumatic optic neuropathy (TON) in children are reported. Twenty-nine children were enrolled in the Affiliated Hospital of Qingdao University from April 1999 to May 2015 for retrospective analysis. Of these 29 patients, 5 received drug therapy, and 24 received drug therapy combined with surgical therapy. Among the patients who received surgical therapy, 23 received nasal endoscopic optic decompression under general anaesthesia, and 1 received nasal endoscopic orbital decompression under general anaesthesia. All the patients were followed up for at least 6 months. In 29 cases, 48.28% (14/29) had visual improvement. Of the 5 patients who received drug therapy, 3 showed improvement (60%). Of the 24 cases who received drug and surgical therapy, 11 showed improvement (45.83%). Of the 22 patients who lost visual sensitivity, 10 showed improvement (45.45%). Of the 7 cases with visual acuity above basic light sensitivity, 4 showed improvement (57.14%). In conclusion, TON in children can lead to poor diagnosis and prognosis because of the difficulty of examining children and their limited language expression ability. Early ophthalmologic examination is therefore essential for children with craniofacial injuries, and proper treatment should be undertaken as soon as possible.

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Minimal Invasive Transcaruncular Optic Canal Decompression for Traumatic Optic Neuropathy

Cited by 8 publications

References 5 publications

Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein

Low-Intensity Pulsed Ultrasound Protects Retinal Ganglion Cell From Optic Nerve Injury Induced Apoptosis via Yes Associated Protein

Optic Nerve Avulsion: Pattern and Etiologies at a Tertiary Eye Care Center in Saudi Arabia: An 8-Year Retrospective Study

Clinical treatment of traumatic optic neuropathy in children: Summary of 29 cases

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