Abstract:The neuropeptide galanin has a 35-year
history as an intriguing
target in drug design owing to its implication as a potential anticonvulsant
and neuronal trophic factor among many other therapeutically interesting
functions including analgesia and mood alteration. In this study,
we report the structural characterization of three synthetic fragments
of the galanin N-terminus in buffered aqueous solution: hGal(2–12)KK,
hGal(1–12)KK, and hGal(1–17)KK. High-field two-dimensional 1H-1H nuclear magnetic resonance… Show more
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