Minimal Impact of Clinical Stage on Prostate Cancer Prognosis Among Contemporary Patients With Clinically Localized Disease

Reese, Adam C.; Cooperberg, Matthew R.; Carroll, Peter R.

doi:10.1016/j.juro.2010.03.025

Cited by 40 publications

(27 citation statements)

References 29 publications

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“…However, no statistical difference between both groups could be found regarding BCR rate. Reese et al reported that clinical stage in 4899 men who underwent RP for localized Pca was predictive for BCR on univariate, rather than multivariate, studies [18]. …”

Section: Preoperative Factorsmentioning

confidence: 99%

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Kotb

Elabbady

2011

Prostate Cancer

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Prostate cancer is one of the most common cancers in Western countries and is associated with a considerable risk of mortality. Biochemical recurrence following radical prostatectomy is a relatively common finding, affecting approximately 25% of cases. The aim of our paper was to identify factors that can predict the occurrence of biochemical recurrence, so the patient can be properly counselled pre- and postoperatively. Medline review of the literatures was done followed by a group discussion on the chosen publications and their valuable influence. Preoperative serum total PSA and clinical stage, together with prostatectomy Gleason grade, tumour volume, and perineural and vascular invasions, were the most important variables found to influence outcome.

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Section: Preoperative Factorsmentioning

confidence: 99%

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Kotb

Elabbady

2011

Prostate Cancer

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“…A minimal role of the clinical stage for risk stratifying has already been shown by Reese et al (11). The T stage could be less important than that established by D' Amico or other widely used risk groupings.…”

Section: Discussionmentioning

confidence: 90%

High-risk prostate cancer: factors predicting biochemical recurrence after radical prostatectomy

Ulys¹,

Ulytė²,

Dziameshka³

et al. 2015

AML

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Background/objective. Predictive criteria are needed to evaluate the risk of disease progression after radical prostatectomy. Such criteria would help to select patients most likely to benefit from adjuvant or multimodality treatment. Our aim was to identify predictive factors for biochemical recurrence among the pre-and post-operative parameters in high-risk prostate cancer patients after radical prostatectomy.Methods. Data on high-risk prostate cancer patients between 2005 and 2009 were retrospectively reviewed in two cancer centers: National Cancer Institute, Vilnius, Lithuania, and N. N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus. 199 patients were selected for the study. The pre-operative independent variables were T stage, pretreatment PSA level and Gleason score. Surgical margins and perineural invasion were additionally known for 122 patients. The outcomes measured were biochemical recurrence free and overall survival. The mean follow-up time was 5.8 years.Results. Lower T stage (p = 0.001) and pretreatment PSA (p = 0.0001) were associated with better survival. In the multivariate analysis of pre-operative factors, high T stage (p = 0.008) and pretreatment PSA (p = 0.009) were predictive of biochemical recurrence. When postoperative parameters were included in the multivariate analysis, only pretreatment PSA (p = 0.01), positive surgical margins (p = 0.003) and perineural invasion (p = 0.03) remained relevant independent predictors of biochemical recurrence.Conclusions. Pretreatment PSA, positive surgical margins and perineural invasion were independent predictors of biochemical recurrence after radical prostatectomy in high-risk prostate cancer patients, while the T stage became insignificant after adjusting for postoperative parameters.

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“…One study has shown that clinical T stage offers no independent information in predicting biochemical recurrence [32]. In addition, Gleason scoring has evolved over the years but there is still a lot of heterogeneity in grading, particularly for smaller volume tumors [33].…”

Section: J-cap Prospective Observational Study: Background Factors Ofmentioning

confidence: 99%

Seventh Joint Meeting of K-J-CaP and CaPSURE: extending the global initiative to improve prostate cancer management

Akaza

Kim

Carroll

et al. 2014

Prostate International

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This report summarizes the presentations and discussions that took place at the Seventh Joint Meeting of the Korea–Japan Study Group of Prostate Cancer (K-J-CaP) and the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) held in Seoul, Korea, in September 2013. The original J-CaP and CaPSURE Joint Initiative has now been established since 2007 and since the initial collaboration between research teams in the United States (US) and Japan, the project has expanded to include several other Asian countries. The objective of the initiative is to analyze and compare data for prostate cancer patients in the participating countries, looking at similarities and differences in patient management and outcomes. Until now the focus has been primarily on data generated within J-CaP and CaPSURE, both large-scale, longitudinal, observational databases of prostate cancer patients in Japan and the US, respectively. This year’s meeting was hosted for the first time in Korea which has recently established its own national database–K-CaP–to add to the wealth of data generated by J-CaP and CaPSURE. As a newly-developed database, K-CaP has also provided a valuable ‘template’ for other countries, such as China and Indonesia, planning to establish their own national databases and this will ultimately allow greater opportunities for international data comparisons. A range of topics was discussed at this Seventh Joint Meeting including comparison of outcomes following androgen deprivation therapy or radical prostatectomy in patients with localized prostate cancer, the use of active surveillance as a treatment option and the triggers for intervention when employing this regimen, patient quality of life during treatment, the impact of comorbidities on outcomes, and a comparison of recent outcomes data between J-CaP and CaPSURE. The participants recognized that prostate cancer was now a global disease and therefore major insights into understanding and improving the management of this condition would arise from global interactions such as this joint initiative.

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Minimal Impact of Clinical Stage on Prostate Cancer Prognosis Among Contemporary Patients With Clinically Localized Disease

Cited by 40 publications

References 29 publications

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

Prognostic Factors for the Development of Biochemical Recurrence after Radical Prostatectomy

High-risk prostate cancer: factors predicting biochemical recurrence after radical prostatectomy

Seventh Joint Meeting of K-J-CaP and CaPSURE: extending the global initiative to improve prostate cancer management

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