Minimal Effect of a High-Fat Meal on the Pharmacokinetics of Once-Daily Granulated mesalamine

Safdi, Alan; Pieniaszek, Hank; Grigston, Andrew; Forbes, William

doi:10.14309/00000434-200809001-01127

Cited by 3 publications

(2 citation statements)

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“…The same investigators studied the effects of a high-fat meal on the absorption of single-dose mesalamine. 10 Systemic concentrations of mesalamine were compared among healthy adults randomized to receive a single dose of mesalamine granules in either a fasting state or following a high-fat meal. Plasma maximum concentration was similar between groups, and a nonsignificant increase in AUC was observed in patients who received mesalamine granules after a high-fat meal.…”

Section: Biopharmaceutics Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 99%

Extended-Release Mesalamine Granules for Ulcerative Colitis

Love

Miller

2012

Ann Pharmacother

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Section: Biopharmaceutics Pharmacokinetics and Pharmacodynamicsmentioning

confidence: 99%

Extended-Release Mesalamine Granules for Ulcerative Colitis

Love

Miller

2012

Ann Pharmacother

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“…The effect of a high-fat meal on the pharmacokinetics of 1.6 g mesalamine granules in 30 healthy volunteers was also analyzed, with no difference shown in the maximum plasma concentration (C max ) or the AUC between the fasting and high-fat states, although the time to C max was increased by a high-fat meal. 22 Based on these results, the once daily extended-release granulated mesalamine may be dosed with or without food.…”

Section: Pharmacokineticsmentioning

confidence: 99%

Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine

Oliveira¹,

Cohen²

2011

DDDT

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The aminosalicylates (5-ASA; also referred to as mesalamine-based agents) are considered as first-line in the maintenance of remission of mild to moderate ulcerative colitis (UC). Traditionally these agents have required a large pill burden and multiple daily dosing regimens which may account for the low adherence rates, especially in patients in remission. Extended-release mesalamine is the first once daily mesalamine product approved by the Food and Drug Administration for the maintenance of UC remission. This review will examine the pharmacokinetics, dosing, efficacy, and safety data of extended-release mesalamine, and discuss the potential role of improving medication compliance and decreasing costs in UC maintenance.

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Once-daily mesalamine granules for ulcerative colitis

Lawlor¹,

Ahmed²,

Moss³

2010

Expert Review of Clinical Immunology

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Mesalamine extended-release capsules (Apriso [Salix Pharmaceuticals, Raleigh, NC, USA]) are the first once-daily mesalamine preparation approved by the US FDA for the maintenance of remission of ulcerative colitis (UC). Each mesalamine extended-release capsule contains granules of a mesalamine-polymer matrix that are coated with a pH-sensitive resin. This design begins releasing mesalamine (0.375 g) once the pH is more than 6 in the ileum and colon. Two clinical trials have reported that mesalamine extended-release capsules (1.5 g/day) maintained remission in 79% of patients with UC who were in clinical remission. Reported adherence with mesalamine extended-release capsules once daily was high (>90%) in these studies. This article examines the efficacy and safety of mesalamine extended-release capsules in the maintenance of remission in patients with UC.

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Minimal Effect of a High-Fat Meal on the Pharmacokinetics of Once-Daily Granulated mesalamine

Cited by 3 publications

References 0 publications

Extended-Release Mesalamine Granules for Ulcerative Colitis

Extended-Release Mesalamine Granules for Ulcerative Colitis

Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine

Once-daily mesalamine granules for ulcerative colitis

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Minimal Effect of a High-Fat Meal on the Pharmacokinetics of Once-Daily Granulated mesalamine

Cited by 3 publications

References 0 publications

Extended-Release Mesalamine Granules for Ulcerative Colitis

Extended-Release Mesalamine Granules for Ulcerative Colitis

Maintaining remission in ulcerative colitis &ndash; role of once daily extended-release mesalamine

Once-daily mesalamine granules for ulcerative colitis

Contact Info

Product

Resources

About

Maintaining remission in ulcerative colitis – role of once daily extended-release mesalamine