Abstract:Multiple risk factors can be modified to decrease asthma incidence. It is important to understand early risks to decrease exposure to harmful conditions in the environment that can trigger asthma which may not be clinically evident in children until they reach adulthood. A retrospective literature review of articles on the prevalence of asthma in the urban versus rural environment was initiated in order to understand the effect of the environment on asthma. The urban-living effect is a global problem in the fa… Show more
“…For example, asthma is a common condition, affecting 1 in 9 school‐aged children . Although pediatric asthma may not be more prevalent in rural versus urban communities in the United States, data indicate that rural children in the United States are more likely than urban children to have uncontrolled asthma, be hospitalized for asthma, and receive inferior care for asthma . Our finding that rural school nurses were less likely than metropolitan nurses to have had recent continuing education on asthma suggests a lack of access to trained health care providers for rural children with asthma.…”
Our findings support the provision of online courses and telehealth content to address urban-rural disparities in school nursing education and support rural school health.
“…For example, asthma is a common condition, affecting 1 in 9 school‐aged children . Although pediatric asthma may not be more prevalent in rural versus urban communities in the United States, data indicate that rural children in the United States are more likely than urban children to have uncontrolled asthma, be hospitalized for asthma, and receive inferior care for asthma . Our finding that rural school nurses were less likely than metropolitan nurses to have had recent continuing education on asthma suggests a lack of access to trained health care providers for rural children with asthma.…”
Our findings support the provision of online courses and telehealth content to address urban-rural disparities in school nursing education and support rural school health.
“…Thus it appears that there may be a link between the development of hypersensitivity diseases and the urbanization or modernization of society [23]. Many urban environments have similar characteristics (lower air quality, higher population density, lower economic status) that predispose populations to asthma; and similar to the geographical disparity of this disease, rural areas with comparable environments do report greater incidences of hypersensitivity diseases [24, 25]. There is also the possibility that urbanization does not support optimal immune development due to a decrease in exposure to environmental microbes as humans shift from an outdoor lifestyle to a more indoor lifestyle that is characteristic of urban societies [26].…”
Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes that changing environmental exposures play a significant role in the etiology of this disease. The microflora hypothesis suggests that early life exposures are disrupting the composition of the microbiota and consequently, promoting immune dysregulation in the form of hypersensitivity disorders. Animal model research supports a role of the microbiota in asthma and atopic disease development. Further, these model systems have identified an early life critical window, during which gut microbial dysbiosis is most influential in promoting hypersensitivity disorders. Until recently this critical window had not been characterized in humans, but now studies suggest that the ideal time to use microbes as preventative treatments or diagnostics for asthma in humans is within the first 100 days of life. This review outlines the major mouse-model and human studies leading to characterization of the early life critical window, emphasizing studies analyzing the intestinal and airway microbiotas in asthma and atopic disease. This research has promising future implications regarding childhood immune health, as ultimately it may be possible to therapeutically administer specific microbes in early life to prevent the development of asthma in children.
“…While past research indicated that asthma prevalence may be lower for children living on or near farms (Reidler et al 2001; Gergen et al 1988), recent investigations suggest that asthma morbidity in the rural US is as high or higher than in urban communities (Chrischilles et al 2004; Pesek et al 2010; Malik et al 2012). Rural communities often face unique barriers to asthma diagnosis and management, such as limited access to health care, poor insurance coverage, poverty, and geographic isolation (Valet et al 2009; Ownby 2005).…”
Background
Elevated pediatric asthma morbidity has been observed in rural US communities, but the role of the ambient environment in exacerbating rural asthma is poorly understood.
Objectives
To investigate associations between particulate matter less than 2.5 μm in diameter (PM2.5) and pediatric asthma exacerbations in an agricultural community of Washington State.
Methods
School-aged children with asthma (n=58) were followed for up to 25 months with repeated measures of respiratory health. Asthma symptoms and quick-relief medication use were assessed biweekly through phone administered surveys (n=2023 interviews). In addition, subjects used home peak flow meters on a daily basis to measure forced expiratory volume in one second (FEV1) (n=7830 measurements). Regional PM2.5 was measured at a single air monitor located centrally in the study region. To assess relationships between PM2.5 and these outcomes we used linear regression with generalized estimating equations, adjusting for meteorological and temporal confounders. Effect modification by atopy was explored as well.
Results
An interquartile increase (IQR) in weekly PM2.5 of 6.7 μg/m3 was associated with an increase in reported asthma symptoms. Specific symptoms including wheezing, limitation of activities, and nighttime waking displayed the strongest associations. FEV1 as a percent of predicted decreased by 0.9% (95%CI: −1.8, 0.0) for an IQR increase in PM2.5 one day prior, and by 1.4% (95%CI: −2.7, −0.2) when restricted to children with atopic asthma.
Conclusions
This study provides evidence that PM2.5 in an agricultural setting contributes to elevated asthma morbidity. Further work on identifying and mitigating sources of PM2.5 in the area is warranted.
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