Abstract:Background: Mutations in the filaggrin gene (FLG) affect epidermal
barrier function and increase the risk of atopic dermatitis (AD). We
hypothesized that FLG mutations affect immune cell composition in a
general pediatric population. Therefore, we investigated if school-aged
children with and without FLG mutations have differences in immune cell
numbers. Methods: This study was embedded in a population-based
prospective cohort study, the Generation R Study, and included 523
children of European genetic ancestr… Show more
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