Minimal asymmetry of the brain: a normal variant

Shapiro, Robert; Galloway, SJ; Shapiro,

doi:10.2214/ajr.147.4.753

Cited by 35 publications

(16 citation statements)

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“…They attributed this finding to greater total striate cortex in the left hemisphere with more exposed mesial cortex than in the right hemisphere. Indeed, MRI brain scan studies have shown most commonly (between 56 and 75%) a greater protrusion of the left occipital lobe beyond the right occipital lobe in human brain anatomy [20,[22][23][24]. Whilst retinotopic or 'normal' half-field distributions are reassuring, it remains possible that they may mask pathology.…”

Section: Discussionmentioning

confidence: 99%

“…The other 49% (cases [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] showed an iP100 to each half-field, but these were atypical in distribution. That is, these half-field responses were more symmetrically distributed across the lateral channels due to variable or absent contralateral negativities in the cPNP complex.…”

Section: Monocular Half-field Pvepsmentioning

confidence: 99%

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When do asymmetrical full-field pattern reversal visual evoked potentials indicate visual pathway dysfunction in children?

et al. 2010

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Our study aimed to find out the association between full-field pattern reversal visual evoked potential (pVEP) transoccipital asymmetries and half-field pVEP transoccipital distributions in children. Over a six-month period, 46 patients (mean age: 9 years 9 months) had both monocular full-field and half-field pVEPs to test checks subtending 50 min of arc in a 35 degree full-field and 0-17.5 degree lateral half-field. Silver-silver chloride electrodes placed at Oz, O1 and O2 were referred to Fz. Monocular full-field data were categorised according to the degree of transoccipital asymmetry. Half-field data were measured and summated to see whether they explained any full-field asymmetry. In this cohort of 46 patients, eight (17%) patients had symmetrically distributed monocular full-field pVEPs for each eye. Four of these patients had normal half-field pVEP distributions for each eye, but the other four showed a half-field deficit in one or both eyes. Of the 38 patients with asymmetrically distributed full-field pVEPs in at least one eye, 17 (44%) patients showed a half-field deficit, 20 (53%) showed responsive, but symmetrically distributed half-field responses, and one patient (3%) showed typical half-field distributions. Half-field pVEPs can help explain full-field asymmetries and should be attempted in any child able to co-operate with testing and in whom visual pathway dysfunction is suspected.

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Section: Discussionmentioning

confidence: 99%

Section: Monocular Half-field Pvepsmentioning

confidence: 99%

When do asymmetrical full-field pattern reversal visual evoked potentials indicate visual pathway dysfunction in children?

et al. 2010

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“…5). Of interest, both the pineal and the habenular nucleus are implicated in CNS L-R asymmetry in lower organisms (Harris et al, 1996;Guglielmoth and Fiorino, 1999;Liang et al, 2000;Bisgrove et al, 2000), and the pineal has been reported to be asymmetric in approximately half of human brains, as evaluated by CT scanning (Shapiro et al, 1986). Not all WNT genes tested demonstrate strong pineal expression; Although WNT7a is also expressed in the ventricular lining of the dorsal diencephalon at this level, it does not show significant pineal expression (Fig.…”

Section: Wnt2b Expression Demarcates Homologous Dorsal Structures In mentioning

confidence: 99%

Wnt genes define distinct boundaries in the developing human brain: Implications for human forebrain patterning

Abu-Khalil

Grove

et al. 2004

J of Comparative Neurology

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Understanding the factors that govern human forebrain regionalization along the dorsal-ventral and left-right (L-R) axes is likely to be relevant to a wide variety of neurodevelopmental and neuropsychiatric conditions. Recent work in lower vertebrates has identified several critical signaling molecules involved in embryonic patterning along these axes. Among these are the Wingless-Int (WNT) proteins, involved in the formation of dorsal central nervous system (CNS) structures, as well as in visceral L-R asymmetry. We examined the expression of WNT2b and WNT7b in the human brain, because these genes have highly distinctive expression patterns in the embryonic mouse forebrain. In the human fetal telencephalon, WNT2b expression appears to define the cortical hem, a dorsal signaling center previously characterized in mouse, which is also confirmed by BMP7 expression. In diencephalon, WNT2b expression is restricted to medial dorsal structures, including the developing pineal gland and habenular nucleus, both implicated in CNS L-R asymmetry in lower organisms. At 5 weeks gestation, WNT7b is expressed in cerebral cortical and diencephalic progenitor cells. As the cortical plate develops, WNT7b expression shifts, demarcating deep layer neurons of the neocortex and the hippocampal formation. Spatial and temporal expression patterns show startling similarity between human and mouse, suggesting that the developmental roles of these WNT genes may be highly conserved, despite the far greater size and complexity of the human forebrain.

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“…У пациентов в остром периоде лакунарного инсульта, по сравне-нию с нормой, достоверно выше были значения C и D, которые характеризуют состояние боковых желу-дочков. Почти нивелировалась характерная для нормы асимметрия боковых желудочков [6], в ос-новном за счет увеличения левого. Размер III желу-дочка превышал норму в 1,85 раза (p<0,01).…”

Section: результаты и обсуждениеunclassified

Some features of morphometric characteristics of the brain in patients with lacunar stroke

Mi¹,

Zv²,

Si³

2014

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Minimal asymmetry of the brain: a normal variant

Cited by 35 publications

References 0 publications

When do asymmetrical full-field pattern reversal visual evoked potentials indicate visual pathway dysfunction in children?

When do asymmetrical full-field pattern reversal visual evoked potentials indicate visual pathway dysfunction in children?

Wnt genes define distinct boundaries in the developing human brain: Implications for human forebrain patterning

Some features of morphometric characteristics of the brain in patients with lacunar stroke

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