Miniaturized total analysis systems for biological analysis

Jakeway, Stephen C.; Mello, Andrew J. de; Russell, Emma L.

doi:10.1007/s002160051548

Cited by 311 publications

(201 citation statements)

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“…This provides us with the capability to manipulate molecules at the nanometer or atomic length scale and create advanced materials for biosensing, biology, and materials science. Detection time, sensitivity, sample size, and cost can be substantially reduced when the length scale of a biosensing system shrinks dramatically [338][339][340][341][342]. In addition, bionanofabrication potentially allows direct interrogation of numerous biomolecules in a parallel manner.…”

Section: Micro-and Nano-structures-mentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

280

231

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Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.

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Section: Micro-and Nano-structures-mentioning

confidence: 99%

Peptide-based biopolymers in biomedicine and biotechnology

Chow

Nunalee

Lim

et al. 2008

Materials Science and Engineering: R: Reports

280

231

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“…Here we assume that the buffer conductivity is linearly proportional to temperature (having slope a) as shown in eqn. (2),…”

Section: Thermal Analysis and Simulation Domainmentioning

confidence: 99%

Joule heating and heat transfer in poly(dimethylsiloxane) microfluidic systems

2003

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Joule heating is a significant problem in electrokinetically driven microfluidic chips, particularly polymeric systems where low thermal conductivities amplify the difficulty in rejecting this internally generated heat. In this work, a combined experimental (using a microscale thermometry technique) and numerical (using a 3D "whole-chip" finite element model) approach is used to examine Joule heating and heat transfer at a microchannel intersection in poly(dimethylsiloxane) (PDMS), and hybrid PDMS/Glass microfluidic systems. In general the numerical predictions and the experimental results agree quite well (typically within ± 3 °C), both showing dramatic temperature gradients at the intersection. At high potential field strengths a nearly five fold increase in the maximum buffer temperature was observed in the PDMS/PDMS chips over the PDMS/Glass systems. The detailed numerical analysis revealed that the vast majority of steady state heat rejection is through lower substrate of the chip, which was significantly impeded in the former case by the lower thermal conductivity PDMS substrate. The observed higher buffer temperature also lead to a number of significant secondary effects including a near doubling of the volume flow rate. Simple guidelines are proposed for improving polymeric chip design and thereby extend the capabilities of these microfluidic systems.

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“…These are composed of micro-fluidic systems including micro-pumps and micro-valves integrated with microelectronic components [55]. Nanotechnology allows miniaturization of these devices which requires high electrical fields strengths that can be obtained by using nanosized electrodes and the membranes based on nanopore separation systems.…”

Section: Lab-on-chipmentioning

confidence: 99%

Emerging Trends in Medical Diagnosis: A Thrust on Nanotechnology

SH¹

2014

Med chem

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Nanotechnology is the manipulation of material on an atomic and molecular scale; by changing its physical, chemical and biological properties to produce novel materials, devices, and systems. Nanomaterials exhibit remarkable characteristics such as high surface to volume ratio, catalytic activity, and biocompatibility which make them suitable for various biomedical applications. Nanotechnology have prospective to improve the whole healthcare process for patient; starts from diagnosis to treatment and follow-up monitoring. Medical diagnosis based on nanotechnology provides two major advantages: rapid testing and early diagnosis. The potential contributions of nanotechnology in the medical diagnosis are extremely broad and improve traditional diagnostic tools and methods in the field of clinical diagnosis, imaging and electro-diagnosis. Emerging modalities such as biochip, microarray, nanobarcode, micro-electromechanical systems, lab on chip and nanobiosensor have revolutionized the field of medical diagnosis. Nanoscale materials and nano-enabled techniques are used for diagnosis of various diseases such as cardiovascular diseases, cancer, diabetes, infectious disease, musculoskeletal and neurodegenerative disease etc. Among all medical applications of nanotechnology, nanobiosensor especially enzyme nanobiosensor are sensitive, reliable, robust, reproducible and cost effective diagnostic tool to meet the requirements of healthcare.

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Miniaturized total analysis systems for biological analysis

Cited by 311 publications

References 0 publications

Peptide-based biopolymers in biomedicine and biotechnology

Peptide-based biopolymers in biomedicine and biotechnology

Joule heating and heat transfer in poly(dimethylsiloxane) microfluidic systems

Emerging Trends in Medical Diagnosis: A Thrust on Nanotechnology

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