Miniaturized system of a gas chromatograph coupled with a Paul ion trap mass spectrometer

Shortt, Brian; Darrach, M. R.; Holland, Paul M.; Chutjian, A.

doi:10.1002/jms.768

Cited by 49 publications

(33 citation statements)

References 14 publications

(14 reference statements)

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“…The JPL team has continuously improved and miniaturized a mass spectrometer, recently adding GC and preconcentrator capabilities to the front end 94 with good performance for most of the listed compounds:…”

Section: Vcam Development Unitmentioning

confidence: 99%

Sensor systems for the Altair Lunar Lander:

Mariella¹

2009

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Section: Vcam Development Unitmentioning

confidence: 99%

Sensor systems for the Altair Lunar Lander:

Mariella¹

2009

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“…[19-24] The advantages of ion trap analyzers include their small size, relatively high operating pressure and the MS/MS capability. Currently, several portable miniature MS instruments have been developed using ion trap mass analyzers, including as the Mini10,[25] Mini 11,[26] and Mini12[27] from Purdue University, Tridion-9 GC-MS[28] from Torion Inc. (American Fork, UT), GC/QIT[29] from the Jet Propulsion Laboratory, Chemsense 600[30] from Griffin Analytical Technology LLC. (West Lafayette, IN), and the MMS-1000 from 1 st Detect Inc. (Austin, TX).…”

Section: Introductionmentioning

confidence: 99%

Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems

Chen

Zhou

et al. 2014

J. Am. Soc. Mass Spectrom.

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Miniature mass spectrometry analytical systems of backpack configuration fitted with sampling probes could potentially be of significant interest for in-field, real-time chemical analysis. In this study, various configurations were explored in which a long narrow tube was used to connect the turbo and backing pumps used to create and maintain vacuum. Also, for the first time we introduced two new types of pumps for miniature mass spectrometers, the Creare 130g drag pump and Creare 350g scroll backing pump. These pumps, along with another Creare 550 turbo pump and the commercially available Pfeiffer HiPace 10 turbo and KnF diaphragm backing pumps, were tested with the backpack configurations. The system performance, especially the scan time, was characterized when used with a discontinuous atmospheric pressure interface (DAPI) for ion introduction. The pumping performance in the pressure region above 1 mtorr is critical for DAPI operation. The 550g turbo pump was shown to have a relatively higher pumping speed above 1 mtorr and gave a scan time of 300 ms, almost half the value obtained with the larger, heavier HiPace 10 often used with miniature mass spectrometers. The 350 g scroll pump was also found to be an improvement over the diaphragm pumps generally used as backing pumps. With a coaxial low temperature plasma ion source, direct analysis of low volatility compounds glass slides was demonstrated, including 1 ng DNP (2,4-Dinitrophenol) and 10ng TNT (2,4,6-trinitrotoluene) with Creare 550g turbo pump as well as 10 ng cocaine and 20 ng DNP with Creare 130g drag pump.

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“…Applications include monitoring public safety areas [1], detecting chemical warfare agents (CWA) in battlefield situations [2,3], analyzing harsh environmental conditions [4,5], ensuring industrial quality control [6], and even screening in medicine [7]. One of the shortcomings for in situ analysis is sample collection, extraction, separation, or other special treatments that are needed for certain samples [8].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, there has been much effort recently in coupling scaled-down gas chromatographs (GC) with portable MS systems [2,3,9,10]. These GC systems have been made more field-portable, and the resulting analysis times have been significantly reduced.…”

Section: Introductionmentioning

confidence: 99%

Multiplexed MS/MS in a Miniature Rectilinear Ion Trap

Graichen

Vachet

2011

J. Am. Soc. Mass Spectrom.

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A multiplexed method for performing MS/MS on multiple ions simultaneously in a miniature rectilinear ion trap (RIT) mass spectrometer has been developed. This method uses an ion encoding procedure that relies on the mass bias that exists when ions are externally injected into an RIT operated with only a single phase rf applied to one pair of electrodes. The ion injection profile under such conditions ions is Gaussian-like over a wide range of rf amplitudes, or low mass cutoff (LMCO) values, during ion accumulation. We show that this distribution is related to ion m/z and is likely caused by ions having an optimal range of pseudo-potential well depths for efficient trapping. Based on this observation, precursor ion intensity changes between two different injection LMCO values can be predicted, and these ion intensity changes are found to be carried through to their corresponding product ions, enabling multiplexed MS/MS spectra to be deconvoluted.

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Miniaturized system of a gas chromatograph coupled with a Paul ion trap mass spectrometer

Cited by 49 publications

References 14 publications

Sensor systems for the Altair Lunar Lander:

Sensor systems for the Altair Lunar Lander:

Design of Portable Mass Spectrometers with Handheld Probes: Aspects of the Sampling and Miniature Pumping Systems

Multiplexed MS/MS in a Miniature Rectilinear Ion Trap

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