Miniaturized continuous flow reaction vessels: influence on chemical reactions

Brivio, Monica; Verboom, Willem; Reinhoudt, David N.

doi:10.1039/b510856j

Cited by 231 publications

(111 citation statements)

References 144 publications

(203 reference statements)

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Micro-fluidic devices are extensively used in many different fields like biomedical [1], pharmaceutical research [2], chemical reaction manifolds [3,4] and for chemical/bio-analysis [5]. In these devices, valves are essential for the control and movement of flows in the microchannels, while simultaneously minimising dead volume.…”

Section: Introductionmentioning

confidence: 99%

Ionogel-based light-actuated valves for controlling liquid flow in micro-fluidic manifolds

et al. 2010

View full text Add to dashboard Cite

We present the fabrication, characterisation and performance of four novel ionic liquid polymer gels (ionogels) as photo-actuated valves incorporated into microfluidic manifolds. The ionogels incorporate benzospiropyran units and phosphonium based ionic liquids. Each ionogel is photo-polymerised in-situ in the channels of a poly(methyl methacrylate) micro-fluidic device, generating a manifold incorporating four different micro-valves. The valves are actuated by simply applying localised white light irradiation, meaning that no physical contact between the actuation impulse (light) and the valve structure is required. Through variation of the composition of the ionogels, each of the micro-valves can be tuned to open at different times under similar illumination conditions. Therefore, flows through the manifold can be independently controlled by a single light source. At present, the contraction process to open the channel is relatively rapid (seconds) while the recovery (expansion) process to re-close the channel is relatively slow (minutes), meaning that the valve, in its current form, is better suited for single-actuation events.

show abstract

Section: Introductionmentioning

confidence: 99%

Ionogel-based light-actuated valves for controlling liquid flow in micro-fluidic manifolds

et al. 2010

View full text Add to dashboard Cite

show abstract

“…208 In the laboratory, micro-reactors are mostly employed and offer numerous advantages. [209][210][211][212][213][214] Safety is increased by using continuous flow reactions instead of batch reactions: thermal runaway is less likely, due to to the dominance of the thermal mass of the system. Moreover, continuous flow reactions allow the use of smaller reactors.…”

Section: General Overview On Continuous Flow Chemistrymentioning

confidence: 99%

Polymer precursors from catalytic reactions of natural oils

et al. 2012

View full text Add to dashboard Cite

Dimethyl 1,19-nonadecanedioate is produced from the methoxycarbonylation of commercial olive, rapeseed or sunflower oils in the presence of a catalyst derived from [Pd 2 (dba) 3 ], bis(ditertiarybutylphosphinomethyl)benzene (BDTBPMB) and methanesulphonic acid (MSA). The diester is then hydrogenated to 1,19-nonadecanediol using Ru/1,1,1-tris-(diphenylphosphinemethyl)ethane (triphos). 1,19-Nonadecadienoic acid is hydrogenated to short chain oligoesters, which can themselves be hydrogenated to 1,19-nonadecanol by hydrogenation in the presence of water.

show abstract

“…Still, the same advantages are highly desirable in syntheses, especially where yield and purity of product depend strongly on kinetic conditions [20], in reactions that are dangerous (e.g., include explosive substrates, intermediates or products) [21], or ones that use particularly expensive reagents or intermediates [22]. Single-phase systems have been widely reported (see for example review by Brivio et al [23]) to yield increased rates of reaction, yields, and selectivities in comparison to traditional batch-syntheses. For example, Haswell et al demonstrated that the aldol reaction between aldehydes and silyl enol ethers in the presence of tetrabutyl ammonium fluoride (TBAF) reaches completion in only 20 min while the batch reaction requires 24 h for the same result [24].…”

Section: Advantages Of Microflow Reactorsmentioning

confidence: 99%

Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

et al. 2015

View full text Add to dashboard Cite

Conducting reactions in droplets in microfluidic chips offers several highly attractive characteristics, among others, increased yield and selectivity of chemical syntheses. The use of droplet microfluidic systems in synthetic chemistry is, however, hampered by the intrinsically small throughput of micrometric channels. Here, we verify experimentally the potential to increase throughput via an increase of the scale of the channels. We use the results of these experiments characterizing the processes of (1) generation of droplets, (2) mixing in droplets, (3) inter-phase extraction, and (4) the yield of synthesis of pyrrole, to postulate a number of guidelines for scaling up the throughput of microfluidic droplet systems. In particular, we suggest the rules for maximizing the throughput via an increase of the size of the channels and via parallelization to optimize the throughput of synthesis against the cost of fabrication of the chips and against the kinetic requirements of specific reactions.

show abstract

Miniaturized continuous flow reaction vessels: influence on chemical reactions

Cited by 231 publications

References 144 publications

Ionogel-based light-actuated valves for controlling liquid flow in micro-fluidic manifolds

Ionogel-based light-actuated valves for controlling liquid flow in micro-fluidic manifolds

Polymer precursors from catalytic reactions of natural oils

Scaling up the Throughput of Synthesis and Extraction in Droplet Microfluidic Reactors

Contact Info

Product

Resources

About