“…Most notably, Bustamante et al 171 measured the mole fraction solubility of piroxicam in 22 different organic solvents, including two saturated hydrocarbons (heptane and cyclohexane), one aromatic hydrocarbon (benzene), one alkyl alkanoate (ethyl ethanoate), one dialkyl ether (1,1′-oxybisethane) and one cyclic ether (1,4-dioxane), two chloroalkanes (trichloromethane and 1,2-dichloroethane) and one chlorinated aromatic hydrocarbon (chlorobenzene), seven alcohols (methanol, ethanol, 1-pentanol, 1-octanol, 1,2-ethanediol, 1,2-propanediol, and 1,2,3-propanetriol), one alkanone (propanone) and one aromatic ketone (acetophenone), and four miscellaneous organic solvents (ethanoic acid, propanoic acid, formamide, and N,Ndimethylformamide) at 298 K and atmospheric pressure. Wyttenbach et al 185 investigated the solubility of piroxicam in ethanol, polyethylene glycol 400, and olive oil at ambient room temperature using a residual solid screening assay method performed in 96-well multiscreen solubility filter plates. Wenkers and Lippold 64 reported solubility data for ten NSAIDs (aspirin, diclofenac, diflunisal, flufenamic acid, ibuprofen, ketoprofen, nabumetone, naproxen, piroxicam, and tenoxicam) in light mineral oil at 305 K. It is not possible to perform a critical evaluation in regard to these solubility data as ethanol is the only common solvent and the independent sets of measurements were performed at different temperatures (298 K and ambient room temperature).…”