Miniaturization of Pressure Filtration Processes for Lean Development

Abstract

As a basic operation of mechanical process engineering, pressure filtration and its scale-up has been described in detail in the literature. But, the pharmaceutical development of active substances, in particular, calls for a scale-up of relatively small quantities to execute downstream processes in a lean and reliable manner. Therefore, development depends on conclusions from smaller filter equipment. In this study, results from laboratory nutsche filters with filter surface areas of 1.4 cm 2 and 9.6 cm 2 were compared with results from a 20 cm 2 nutsche. It has been shown that no reproducible and reliable data could be generated using the 1.4-cm 2 nutsche. While this was possible using the 9.6 cm 2 nutsche, the permeability was greater than with the recommended 20 cm 2 nutsche so that a correction factor has to be introduced.

An Integrated Fouling Monitoring Technique for a Water Treatment Microfiltration Process

“…The slurry was agitated in the slurry supply tank with a magnetic disk and was kept well mixed by pumping the slurry at a moderate rate through a pressure filter. In each experiment, the filtration pressure was supplied by compressed air and was adjusted to a given value by a pressure regulator [26,27]. The stainless steel filter chamber has a filtration area of 19.6 · 10 -4 m 2 .…”