Miniaturization of package for an implantable heart monitoring device

Nguyen, Anh-Tuan Thai; Tjuļkins, Fjodors; Aasmundtveit, Knut E.; Høivik, Nils; Hoff, Lars; Imenes, Kristin

doi:10.1007/s00542-014-2216-6

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…A flexible polyimide substrate was used as the substrate for the accelerometer and necessary filter capacitors. The layered structure of the substrate was the same as in the cablesubstrate in Tjulkins et al [12], and Nguyen et al [13].…”

Section: Sensor and Electric Interconnectionmentioning

confidence: 98%

“…The sensor dimensions are 2 Â 2 Â 0.95 mm 3 . The sensor used is the same as described earlier [12][13][14].…”

Section: Sensor and Electric Interconnectionmentioning

confidence: 99%

“…Then they are pulled out if no longer needed. We have previously presented a miniaturized device, with dimensions 2.8 Â 3 Â 10 mm 3 with silicone encapsulation with the possibility to be placed sub-epicardially [12][13][14] (Figure 1, upper row left). For the placement of this device a four-step Seldingers technique was *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and assembly of MEMS accelerometer-based heart monitoring device with simplified, one step placement

Tjuļkins

Nguyen

Andreassen

et al. 2014

Journal of Medical Engineering & Technology

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An accelerometer-based heart monitoring system has been developed for real-time evaluation of heart wall movement. In this paper, assembly and fabrication of an improved device is presented along with system characterization and test data from an animal experiment. The new device is smaller and has simplified the implantation procedure compared to earlier prototypes. Leakage current recordings were well below those set by the corresponding standards.

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Section: Sensor and Electric Interconnectionmentioning

confidence: 98%

“…The sensor dimensions are 2 Â 2 Â 0.95 mm 3 . The sensor used is the same as described earlier [12][13][14].…”

Section: Sensor and Electric Interconnectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication and assembly of MEMS accelerometer-based heart monitoring device with simplified, one step placement

Tjuļkins

Nguyen

Andreassen

et al. 2014

Journal of Medical Engineering & Technology

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“…Although the physical size of a combined accelerometer + gyro at present is too large to be considered clinically feasible, 10 the development of miniaturized sensors is progressing fast. In the future, this miniaturization will allow use of even more sophisticated sensors like 9 axis combined accelerometer, gyro, and magnetometer which can estimate the orientation of the sensor in real time with high accuracy.…”

Section: Accuracy Of Gyrc Compensated Motion Measurementsmentioning

confidence: 99%

Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements

et al. 2017

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A miniaturized accelerometer fixed to the heart can be used for monitoring of cardiac function. However, an accelerometer cannot differentiate between acceleration caused by motion and acceleration due to gravity. The accuracy of motion measurements is therefore dependent on how well the gravity component can be estimated and filtered from the measured signal. In this study we propose a new method for estimating the gravity, based on strapdown inertial navigation, using a combined accelerometer and gyro. The gyro was used to estimate the orientation of the gravity field and thereby remove it. We compared this method with two previously proposed gravity filtering methods in three experimental models using: (1) in silico computer simulated heart motion; (2) robot mimicked heart motion; and (3) in vivo measured motion on the heart in an animal model. The new method correlated excellently with the reference (r > 0.93) and had a deviation from reference peak systolic displacement (6.3 ± 3.9 mm) below 0.2 ± 0.5 mm for the robot experiment model. The new method performed significantly better than the two previously proposed methods (p < 0.001). The results show that the proposed method using gyro can measure cardiac motion with high accuracy and performs better than existing methods for filtering the gravity component from the accelerometer signal.

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“…It has been demonstrated that a triple‐axis accelerometer attached to the epicardium can be used to monitor heart motion and detect early signs of coronary occlusion (Elle et al, 2005; Halvorsen, et al 2008). Nguyen et al (2015) . reported a myocardial‐implantable accelerometer for monitoring heart activity as a means to provide early warning when a coronary artery is occluded (Figure 7).…”

Section: Medical Implant Innovations Enabled By Polymeric Packaging Mmentioning

confidence: 99%

Non‐hermetic packaging of biomedical microsystems from a materials perspective: A review

et al. 2020

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Traditionally, implantable electronic devices have used metal-based hermetic encapsulation to protect the internal components from damage by the aggressive in vivo environment. Concurrently, hermetic encapsulation protects the surrounding tissue from harmful substances that might be leached from the packaged components (Bazaka & Jacob, 2012). In some cases, however, there is risk of electrochemical corrosion on the metallic surfaces because of the presence of various ions, amino acids, proteins and dissolved oxygen (Eliaz, 2019). Hermeticity is defined as the ability of sealed packages to resist foreign gases and liquids from penetrating the seal or encapsulating material (Madduri, Sammakia, Infantolino, & Chaparala, 2008). Hermetic packages are conventionally made from glass, metal or ceramic materials whereby the gas and moisture permeability through the material is negligible (Madduri et al., 2008; Schuettler, Schatz, Ordonez, & Stieglitz, 2011). Hermetic materials have been successfully used to package devices for chronic applications, some of the most notable being cochlear implants and cardiac pacemakers (Kirsten, Wetterling, Uhlemann, Wolter, & Zigler, 2013). Titanium is the most commonly used metal for hermetic encapsulation because of its biocompatibility, low permeability for ions and moisture, mechanical durability and the ability to create viable hermetic seals by laser welding (Amanat, James, & McKenzie, 2010). Ceramics have also been used for implants for wireless devices to address issues related to attenuation of electromagnetic transmission by metallic packaging (El Khatib, Pothier, Crunteanu, & Blondy, 2007; Schubring & Fujita, 2007; Shen & Maharbiz, 2019). Driven by the increased functionality and scalability offered by innovations in application-specific integrated circuits (ASICs) and the desire to create highly miniaturized devices on flexible polymer substrates, significant efforts have been made in creating miniaturized implants by integrating the majority of components on a single chip. As the

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Miniaturization of package for an implantable heart monitoring device

Cited by 8 publications

References 24 publications

Fabrication and assembly of MEMS accelerometer-based heart monitoring device with simplified, one step placement

Fabrication and assembly of MEMS accelerometer-based heart monitoring device with simplified, one step placement

Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements

Non‐hermetic packaging of biomedical microsystems from a materials perspective: A review

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