Miniaturised medium pressure capillary liquid chromatography system with flexible open platform design using off-the-shelf microfluidic components

Li, Yan; Dvorak, M.W.; Nesterenko, Pavel N.; Stanley, Roger; Nuchtavorn, Nantana; Krčmová, Lenka Kujovská; Aufartová, Jana; Macka, Mirek

doi:10.1016/j.aca.2015.09.015

Cited by 46 publications

(29 citation statements)

References 27 publications

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“…Encouragingly, this a very active area of research with several very different approaches. Miniature pressure-generating pumps based on piston pumps; syringe pumps; latent energy pumping; and electroosmotic pumps (EOPs) have all been reported [58,[65][66][67]. There are certain features which the ideal portable pumping system should possess: it should be lightweight and batteryoperable; capable of a wide range of flow rates (nL-µL-mL/ min); provide high flow rate accuracy and precision; generate a constant flow rate independent of back pressure; capable of gradient elution with high reproducibility; simple to channel from the inlet to the outlet.…”

Section: The High Pressure Pumpmentioning

confidence: 99%

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A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

et al. 2020

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There is a growing need for chemical analyses to be performed in the field, at the point of need. Tools and techniques often found in analytical chemistry laboratories are necessary in performing these analyses, yet have, historically, been unable to do so owing to their size, cost and complexity. Technical advances in miniaturisation and liquid chromatography are enabling the translation of these techniques out of the laboratory, and into the field. Here we examine the advances that are enabling portable liquid chromatography (LC). We explore the evolution of portable instrumentation from its inception to the most recent advances, highlighting the trends in the field and discussing the necessary criteria for developing in-field solutions. While instrumentation is becoming more capable it has yet to find adoption outside of research.

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Section: The High Pressure Pumpmentioning

confidence: 99%

“…The system was reported to achieve high pressures. However, these syringe pumps are not designed for precision flow or high-pressure applications [65] since there is considerable variation between pumps in manufacture and all suffer from pronounced oscillatory flow profiles. These issues are not covered in published accounts.…”

Section: Et Al (2015)mentioning

confidence: 99%

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

et al. 2020

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“…Column robustness issues and extra‐column band broadening related to poor connections in capillary systems are reduced through the use of a novel cartridge design that applies appropriate torque for fluidic connections at pressures up to 10 000 psi. This is in contrast to other portable LC systems that employ more traditional LC column integration and lower pressure limits . This first report demonstrating the use of the new, compact LC system addresses several common applications in the pharmaceutical and forensic fields.…”

Section: Introductionmentioning

confidence: 98%

Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis

Foster

Xie

Pham

et al. 2020

J of Separation Science

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A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high‐pressure syringe pumps capable of delivering capillary‐scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub‐2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high‐pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over‐the‐counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six targeted drug panels. The results described in this study demonstrate the capability of this compact liquid chromatography instrument to address several important drug‐related applications while simplifying system operation, and greatly reducing solvent usage and waste generation essential for onsite analysis.

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“…[7] был предложен портативный жидкостный хроматограф с электрохимическим детектором, работающий на батареях. Десять лет позднее Г.Барам с сотрудниками [8,9] [16][17][18][19][20][21]. Первые детекторы на светодиодах в красном свете появились в 60-х годах [16], позднее были разработаны в УФ, видимом и инфракрасных (ИК) областях [17].…”

Section: Introductionunclassified

Портативные Жидкостные Хроматографы

Yashin¹,

Vedenin²,

Yashin³

2019

sorpchrom

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В кратком обзоре приведены основные данные о портативных жидкостных хроматографах: истории появления, состав, применяемые детекторы, колонки, насосы и области применения. Приведен перечень коммерческих портативных жидкостных хроматографов. Миниатюризация приборов - одна из основных тенденций развития в хроматографии. Основные области применения портативных жидкостных хроматографов - это анализ на месте события или происшествия: это контроль окружающей среды, пищевых продуктов на рынках и супермаркетах, клинические анализы у постели больного, судебно-токсикологические анализы и др. Портативные жидкостные хроматографы должны иметь небольшой размер и вес, должны работать автономно и надежно, иметь низкое потребление электроэнергии и расходных материалов. Основные детекторы, используемые в портативных жидкостных хроматографах - УФ на светодиодах и электрохимические. Основной толчок развитию портативных жидкостных хроматографов дала разработка портативного электроосмотического насоса высокого давления. В портативных жидкостных хроматографах используются наноколонки, капиллярные колонки и микронасадочные колонки. В некоторых случаях используется даже градиентное элюирование. Около десяти фирм начали разработку или уже выпускают портативные жидкостные хроматографы для биоанализов, диагностики заболеваний, контроля загрязнений. В качестве детекторов, кроме вышеупомянутых, стали использоваться масс-спектрометрические, флуориметрические и хемилюминесцентные. Несомненно, следует ожидать новых портативных жидкостных хроматографов.

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Miniaturised medium pressure capillary liquid chromatography system with flexible open platform design using off-the-shelf microfluidic components

Cited by 46 publications

References 27 publications

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

A Review of Portable High-Performance Liquid Chromatography: the Future of the Field?

Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis

Портативные Жидкостные Хроматографы

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