Miniature probe for the delivery and monitoring of a photopolymerizable material

Schmocker, Andreas; Khoushabi, Azadeh; Schizas, Constantin; Bourban, P.-E.; Pioletti, Dominique P.; Moser, Christophe

doi:10.1117/1.jbo.20.12.127001

Cited by 14 publications

(21 citation statements)

References 28 publications

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“…It was demonstrated that the addition of NFC reinforcements improves the hydrogel stiffness without compromising the failure strength or significant reduction of the water content. Moreover, the incorporated NFC fibers were shown to serve as a light-scattering source when the precursor solution is illuminated by UV light [22]. The latter accelerates the kinetics of photopolymerization and consequently allows reducing the required concentration of photoinitiator.…”

Section: Introductionmentioning

confidence: 99%

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Khoushabi

Wyss

Caglar

et al. 2018

Composites Science and Technology

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A B S T R A C TOne of the novel approaches for discogenic lower back pain treatment is to permanently replace the core of the intervertebral disc, so-called Nucleus Pulposus, through minimally invasive surgery. Recently, we have proposed Poly(Ethylene Glycol) Dimethacrylate (PEGDM) hydrogel reinforced with Nano-Fibrillated Cellulose (NFC) fibers as an appropriate replacement material. In addition to the tuneable properties, that mimic those of the native tissue, the surgeon can directly inject it into the degenerated disc and cure it in situ via UV-light irradiation. However, in view of clinical applications, the reliability of the proposed material has to be tested under long-term fatigue loading. To that end, the present study focused on the characterization of the fatigue behavior of the composite hydrogel and investigated the governing physical phenomena behind it. The results show that composite PEGDM-NFC hydrogel withstands the 10 million compression cycles at physiological condition. However, its modulus decreases by almost 10% in the first cycle and then remains constant, while cyclic loading does not affect the neat PEGDM hydrogel. The observed softening behavior has similar characteristics of the Mullins effect. It is shown that the reduction of modulus is due to the gradual change of NFC network, which is highly stretched in the swollen state. Moreover, the swelling degree of the matrix is correlated to the extent of softening during cyclic loading. Consequently, softening can be minimized by lowering the swelling of the composite hydrogel.

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Section: Introductionmentioning

confidence: 99%

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Khoushabi

Wyss

Caglar

et al. 2018

Composites Science and Technology

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“…5c) by recording the reflected illumination spectra at different time points and by tracking the signal intensity over time. The intensity correlates directly with size of the photopolymerized hydrogel volume inside the tissue as previously shown [48]. Thus, if a known volume of hydrogel is injected, the signal intensity can be used to determine the time point of the full polymerization.…”

Section: Implantationmentioning

confidence: 71%

“…c) By recording the reflected illumination spectra a signal intensity is calculated. The intensity of the signal correlates with the amount of photopolymerized material and therefore provides valuable information about the reaction state of the implant in real time [48]. d) IVD during photopolymerization.…”

Section: Discussionmentioning

confidence: 99%

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A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

et al. 2016

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a b s t r a c tNucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus.

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“…Indeed, photoactivation can be triggered precisely by the operator by selectively switching the illumination module on. Moreover, it is theoretically possible to implement a feedback loop coupled to sound to monitor the solidification process by using light of a different wavelength through the same optical fiber (Schmocker et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

Poupart

Schmocker

Conti

et al. 2020

Front. Bioeng. Biotechnol.

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Intracranial aneurysms are increasingly being treated with endovascular therapy, namely coil embolization. Despite being minimally invasive, partial occlusion and recurrence are more frequent compared to open surgical clipping. Therefore, an alternative treatment is needed, ideally combining minimal invasiveness and long-term efficiency. Herein, we propose such an alternative treatment based on an injectable, radiopaque and photopolymerizable polyethylene glycol dimethacrylate hydrogel. The rheological measurements demonstrated a viscosity of 4.86 ± 1.70 mPa.s, which was significantly lower than contrast agent currently used in endovascular treatment (p = 0.42), allowing the hydrogel to be injected through 430 µm inner diameter microcatheters. Photorheology revealed fast hydrogel solidification in 8 min due to the use of a new visible photoinitiator. The addition of an iodinated contrast agent in the precursor contributed to the visibility of the precursor injection under fluoroscopy. Using a customized light-conducting microcatheter and illumination module, the hydrogel was implanted in an in vitro silicone aneurysm model. Specifically, in situ fast and controllable injection and photopolymerization of the developed hydrogel is shown to be feasible in this work. Finally, the precursor and the polymerized hydrogel exhibit no toxicity for the endothelial cells. Photopolymerizable hydrogels are expected to be promising candidates for future intracranial aneurysm treatments.

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Miniature probe for the delivery and monitoring of a photopolymerizable material

Cited by 14 publications

References 28 publications

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

Tailoring swelling to control softening mechanisms during cyclic loading of PEG/cellulose hydrogel composites

A photopolymerized composite hydrogel and surgical implanting tool for a nucleus pulposus replacement

In vitro Implementation of Photopolymerizable Hydrogels as a Potential Treatment of Intracranial Aneurysms

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