Miniature forward-viewing spectrally encoded endoscopic probe

Zeidan, Adel; Yelin, Dvir

doi:10.1364/ol.39.004871

Cited by 6 publications

(7 citation statements)

References 17 publications

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“…Spectrally encoded imaging, including fiber optic probe [54][55][56] and free space microscopy [57,58] and ophthalmoscopy [49,50] implementations, has been described extensively in the literature. These previous publications include theoretical derivations of resolution and SNR, methods for resolving spectroscopic and functional contrast, and detailed descriptions of different illumination and detection schemes.…”

Section: Methodsmentioning

confidence: 99%

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Malone

El‐Haddad

Bozic

et al. 2016

Biomed. Opt. Express

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Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speed imaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we present a multimodal ophthalmic imaging system using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography (SS-SESLO-OCT) for human retinal imaging. SESLO reduces the complexity of imaging systems by multiplexing spatial positions as a function of wavelength. SESLO image quality benefited from single-mode illumination and multimode collection through a prototype double-clad fiber coupler, which optimized scattered light throughput and reduce speckle contrast while maintaining lateral resolution. Using a shared 1060 nm swept-source, shared scanner and imaging optics, and a shared dual-channel high-speed digitizer, we acquired inherently co-registered retinal images and OCT cross-sections simultaneously at 200 frames-per-second.

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Section: Methodsmentioning

confidence: 99%

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Malone

El‐Haddad

Bozic

et al. 2016

Biomed. Opt. Express

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“…The design and construction of our forward-viewing separate-channel SEE probe was described in detail in a previous publication [8]. Briefly, the illumination channel ( Fig.…”

Section: Setupmentioning

confidence: 99%

“…Reflections from the spectrally encoded lines were recorded by the spectrometer with minimum exposure time of 10 μs/line; however, data transfer was considerably slower at 4.4 ms/line, limited only by the camera read rate. Image data was transformed from polar to Cartesian coordinates for obtaining the true cylindrical field of view [8]. The longest 700 nm and the shortest 400 nm wavelengths encoded the outer (proximal) and inner (distal) circles of the cylindrical field-ofview, respectively ( Fig.…”

Section: Setupmentioning

confidence: 99%

“…Reduced speckle noise and increased depth-of-field were achieved using a dual-clad fiber [5] or using separate illumination and collection channels [6,7]. Recently, we have designed a forward-viewing SEE probe [8] that overcomes some of the limitations of side-viewing probes [2,9], potentially allowing practical navigation through narrow passages and ducts. Yet, the use of wavelength to encode space prevents SEE from straightforward color imaging, as only a narrow spectral band is detected from each sample location at any given time.…”

Section: Introductionmentioning

confidence: 99%

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Spectral imaging using forward-viewing spectrally encoded endoscopy

Zeidan

Yelin

2016

Biomed. Opt. Express

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Spectrally encoded endoscopy (SEE) enables miniature, smalldiameter endoscopic probes for minimally invasive imaging; however, using the broadband spectrum to encode space makes color and spectral imaging nontrivial and challenging. By careful registration and analysis of image data acquired by a prototype of a forward-viewing dual channel spectrally encoded rigid probe, we demonstrate spectral and color imaging within a narrow cylindrical lumen. Spectral imaging of calibration cylindrical test targets and an ex-vivo blood vessel demonstrates highresolution spatial-spectral imaging with short (10 μs/line) exposure times.

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“…The majority of these SEE devices were designed with large side‐viewing angles , which prevents their use for any application that requires navigation through confined cavities. Recently, a forward‐viewing SEE device using two separate channels for illumination and detection was demonstrated to be useful for monochromatic and spectral imaging. In these previous SEE devices , broadband light was transmitted through the illumination channel, composed of a 200‐µm‐diameter multimode fiber (MMF).…”

Section: Introductionmentioning

confidence: 99%

High‐Resolution, Wide‐Field, Forward‐Viewing Spectrally Encoded Endoscope

Zeidan

Kang

et al. 2019

Lasers Surg Med

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Background and Objective Spectrally encoded endoscopy (SEE) is an optical imaging technology that uses spatial wavelength multiplexing to conduct endoscopy in miniature, small diameter probes. Contrary to the previous side‐viewing SEE devices, forward‐viewing SEE probes are advantageous as they provide a look ahead that facilitates navigation and surveillance. The objective of this work was to develop a miniature forward‐viewing SEE probe with a wide field of view and a high spatial resolution. Materials and Methods We designed and developed a forward‐viewing SEE device with an overall total diameter of 1.27 mm, which consists of a monolithic illumination probe with a length of 3.87 mm and a diameter of 500 µm, 8 multimode detection fibers that were polished at a 17° angle, a rotational scanning mechanism, and a sheath. The SEE device was evaluated using a USAF resolution target and was used for preclinical imaging of a swine joint ex vivo. Results This design resulted in a high resolution probe (best spatial resolution of 20.3 µm), a wide total angular field of view of 100°, and an effective number of imaging elements of ~344,000 pixels. The SEE probe performance was compared to a commercial color chip‐on‐the‐tip endoscope; while monochrome, results showed better spatial resolution and a wider field of view for the SEE device. Conclusion These results demonstrate the potential of this forward‐viewing SEE probe for visualization and navigation in medical imaging applications. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Miniature forward-viewing spectrally encoded endoscopic probe

Cited by 6 publications

References 17 publications

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

Spectral imaging using forward-viewing spectrally encoded endoscopy

High‐Resolution, Wide‐Field, Forward‐Viewing Spectrally Encoded Endoscope

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