Mini-review: Enteric glial cell reactions to inflammation and potential therapeutic implications for GI diseases, motility disorders, and abdominal pain

Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and whose afferents are distributed throughout the different layers of the digestive wall. The vagus nerve is a key element of the autonomic nervous system, involved in the stress response, at the interface of the microbiota‐gut‐brain axis, has anti‐inflammatory and prokinetic properties, modulates intestinal permeability, and has a significant capacity of plasticity and regeneration. Targeting these properties of the vagus nerve, with vagus nerve stimulation (or non‐stimulation/ pharmacological methods), could be of interest in the therapeutic management of enteric neuropathies.

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Enteric glia as friends and foes of the intestinal epithelial barrier function

Bali,

Grubišić

2024

Front. Immunol.

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Mini-review: Enteric glial cell reactions to inflammation and potential therapeutic implications for GI diseases, motility disorders, and abdominal pain

Cited by 3 publications

References 40 publications

Vitamins and fatty acids against chemotherapy-induced intestinal mucositis

Vitamins and fatty acids against chemotherapy-induced intestinal mucositis

Enteric neuropathy and the vagus nerve: Therapeutic implications

Enteric glia as friends and foes of the intestinal epithelial barrier function

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