Mini-Mental State Examination subscores indicate visuomotor deficits in Alzheimer's disease patients: A cross-sectional study in a Dutch population

Boer, Casper de; Mattace-Raso, Francesco; Steen, J. van der; Pel, J.J.M.

doi:10.1111/ggi.12183

Cited by 24 publications

(20 citation statements)

References 29 publications

(66 reference statements)

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“…Although AD is typically associated with impairments in memory and other aspects of cognition, it has been suggested that visuomotor function is equally impaired in patients with AD (de Boer, Mattace‐Raso, van der Steen, & Pel, ). Crucially, a subtle deterioration in visuomotor control has been observed, not only in patients with fully developed AD, but also at earlier stages (Tippett et al ., ; Verheij et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Subtle visuomotor difficulties in preclinical Alzheimer's disease

Mollica

Navarra

Fernández-Prieto

et al. 2015

Journal of Neuropsychology

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Section: Discussionmentioning

confidence: 99%

Subtle visuomotor difficulties in preclinical Alzheimer's disease

Mollica

Navarra

Fernández-Prieto

et al. 2015

Journal of Neuropsychology

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“…In the current study, we extend this line of investigation by examining subtests of the MMSE in drivers with CI and with NCI. Studies underscore the importance of MMSE subtests . The MMSE includes tasks of orientation, attention, language, visuomotor, and memory skills.…”

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confidence: 99%

“…Studies underscore the importance of MMSE subtests. 11 The MMSE includes tasks of orientation, attention, language, visuomotor, and memory skills. Each task is associated with distinct neural underpinnings, and performance deteriorates in conjunction with select patterns of neural degeneration.…”

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confidence: 99%

Use of the MMSE in the Prediction of Driving Fitness: Relevance of Specific Subtests

O’Connor

Duncanson

Hollis

2019

J American Geriatrics Society

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OBJECTIVES To examine the association between performance on subtests of the Mini‐Mental State Examination (MMSE) and driving competence in people with cognitive impairment (CI) as well as those with no cognitive impairment (NCI). DESIGN Retrospective observational study. SETTING Participants referred for a DriveWise evaluation at Beth Israel Deaconess Medical Center in Boston, Massachusetts, were included in the study. PARTICIPANTS A total of 419 participants referred for a DriveWise evaluation was studied. The average age of the sample was 77.69 years. In this study, people with an MMSE score lower than 25 were included in the CI group; 41% of participants had CI. MEASUREMENTS All participants underwent mental status screening with the MMSE, and all underwent a 45‐minute road test modeled after the Washington University Road Test adapted for use in Boston streets. RESULTS In both groups, poor road test performance was associated with low scores on the MMSE. In drivers with CI, MMSE total score and performance on the attention subtest were significantly lower for those who failed the road test. In drivers with NCI, the MMSE total score and orientation subtests were significantly lower for those who failed the road test. CONCLUSIONS Clinicians working with older people should know that the MMSE is an effective tool to screen for driving safety, but MMSE subtests are differentially sensitive to driving safety in people with and without CI. Poor performance on specific MMSE subtests may prompt further evaluation of driving competence with a road test. J Am Geriatr Soc 67:790–793, 2019.

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“…Alziemer's disease normally has an amnestic presentation, yet a non-amnestic presentation is also possible and in fact some claim that the memory function and the visuomotor function are equally impaired (5). The visual variant of the AD was described by Grunthal (6); in Snowden's et al series (7) the frequency was 5%.…”

Section: Resultsmentioning

confidence: 99%

“…Several authors examined visual deficits using neuropsychological tests and reaching discordant results. Indeed some recognized visuospatial deficits in the early stages (5,29) whereas others found evidence only in the latter stages of the disease (30,31). According to Paxton et al (30), these deficits may be useful in tracking the disease's course.…”

Section: Resultsmentioning

confidence: 99%

Ocular and Visual Manifestation of Alzheimer’s Disease: A Literature Review II Part: Clinical Studies

Raudino

2019

Arch Neurosci

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Context: Visual disturbances are frequent in Alzheimer's disease (AD) and sometimes AD begins with visual disturbances, therefore many researchers have examined the eyes in order to confirm the diagnosis, to monitor the development of the disease or the response to drugs. Evidence Acquisition: Medline literature until March 2018. Results: Several indications suggest an early involvement of the visual system in AD, yet this evidence remains inconclusive. The reason for this uncertainty is two folds: The poor quality of the studies and the fact that some alterations are not unique to the AD, since they also occur in others degenerative CNS diseases. Conclusions: The eye can be a perfect place for early diagnosis of AD and to evaluate the effectiveness of therapies more studies are needed.

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Mini-Mental State Examination subscores indicate visuomotor deficits in Alzheimer's disease patients: A cross-sectional study in a Dutch population

Cited by 24 publications

References 29 publications

Subtle visuomotor difficulties in preclinical Alzheimer's disease

Subtle visuomotor difficulties in preclinical Alzheimer's disease

Use of the MMSE in the Prediction of Driving Fitness: Relevance of Specific Subtests

Ocular and Visual Manifestation of Alzheimer’s Disease: A Literature Review II Part: Clinical Studies

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