Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)

Abstract

Background Dementia is a progressive global cognitive impairment syndrome. In 2010, more than 35 million people worldwide were estimated to be living with dementia. Some people with mild cognitive impairment (MCI) will progress to dementia but others remain stable or recover full function. There is great interest in finding good predictors of dementia in people with MCI. The Mini-Mental State Examination (MMSE) is the best-known and the most often used short screening tool for providing an DTA 20 Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people...

Computational integration of nanoscale physical biomarkers and cognitive assessments for Alzheimer’s disease diagnosis and prognosis

“…Commonly used assessments, including the Mini-Mental State Examination (MMSE) ( 20 ), can provide brief screening tests that quantitatively assess the severity of cognitive impairment and document cognitive changes occurring over time ( 21 ). However, they have sensitivity limitations due to their reliance on conditional factors, such as patient perceptions, education levels, test familiarizations, responses, and performance ( 22 ). Although diagnostic approaches that focus solely on biochemical analysis and brain imaging ( 23 ) play a role as important complementary tools for cogitative assessments, they do not comprehensively capture the complex nature of macro- to nanolevel changes that occur during disease progression ( 12 – 15 ).…”

Detecting Change over Time: A Comparison of the SLUMS Examination and the MMSE in Older Adults at Risk for Cognitive Decline

“…Within the converter or reverser categories, the SLUMS demonstrated higher magnitude score changes and higher standard deviations than the MMSE. More individuals reversed on the SLUMS compared to the MMSE, which might be explained by the SLUMS exam’s superior detection of very mildly impaired cognition [1, 3, 4, 5, 6, 7, 8]. The higher percentage of converters, overall negative change-over-time, and more dramatic score change in converters than reversers for the MMSE could suggest that the MMSE is more sensitive than the SLUMS for detecting cognitive statuses that decline into the dementia range.…”

“…The Mini-Mental State Examination (MMSE) arose from the need for a brief screening tool that could be administered in primary care settings and alert caregivers to the need for comprehensive diagnostic testing. However, the MMSE has significant ceiling effects, reliably detecting dementia but not MCI [1, 3–8]. …”

Effects of dexmedetomidine hydrochloride on hemodynamics, postoperative analgesia and cognition in cesarean section

“…Montreal Cognitive Assessment (MoCA) was used to evaluate the condition of patients at 1 day before and after operation through 8 aspects including executive ability, memory, attention, nomenclature, language, delayed recall, abstract thinking and directionality (8). Mini-Mental State Examination (MMSE) was used to evaluate the orientation force, language, memory, attention and computational power of patients (9).…”