Mini-Mental Parkinson: First Validation Study of a New Bedside Test Constructed for Parkinson’s Disease

Abstract

We have developed a brief screening test aimed at identifying cognitive disorders in Parkinson's disease. The Mini-Mental Parkinson derives from the Mini-Mental State Examination of Folstein. It includes seven ordered subsections, with a total score of 32. A pilot study was conducted in 50 community-dwelling parkinsonian patients, in order to establish its metrological qualities. Comparisons were made with a neuropsychological battery including several tests widely used in the assessment of specific cognitive disorders in Parkinson's disease. The correlations between the Mini-Mental Parkinson and each component of this battery were substantial, especially for the performance subtests of the WAIS-R (r = 0.62 to 0.72), the Stroop test (r = 0.65) the 15-objects test (r = 0.64), the word fluency (r = 0.63) and the Odd Man Out test (r = 0.61). The validity of each subtest of the Mini-Mental Parkinson was adequate except for one, based on a word choice, which requires a modification in French before definitive use. The test-retest reliability was high (r = 0.84). There was a significant difference in the mean scores in cases with confusional event (22.4), even without current signs of dementia, compared with patients with no such history (27.2). In conclusion, this brief test is suitable for assessment of parkinsonian patients.

Cognitive impairment in Parkinson's disease: Tools for diagnosis and assessment

“…Sixteen out of the 33 articles accomplished the quality criteria indicated in the methods section. [16][17][18][19][20][27][28][29][30][31][32][33][34][35] Eight scales were finally selected: four were not specifically designed for PD and assess global cognitive function or frontal-lobe dysfunction, 32,[36][37][38] and four were specifically designed for PD [17][18][19][20] (Table 1).…”

“…To identify the diagnostic and assessment tools that best capture the cognitive changes occurring throughout the course of PD, we have conducted a systematic review of the clinimetric aspects and suitability of scales that have been specifically designed for PD, [17][18][19][20] or reported to detect the cognitive alterations most frequently observed in PD.…”

“…17 It includes seven-ordered subsections assessing orientation, visual registration, attention, verbal fluency, visual recall, setshifting, and concept processing. Although validated against a comprehensive neuropsychological examination, only the pilot study was published and the MiniMental Parkinson (MMP) was not subjected to extensive clinimetric evaluation.…”

“…No information was provided regarding internal consistency, test-retest or inter-rater reliability. Limitations of the scale include heavy representation of the orientation item (10 of 32 points), which is also the item contributing least to scale variance, 17 and the lack of cortically mediated cognitive items. One posterior study has shown that the MMP scores correlate well with the MDRS scores (r 5 0.71), although correlation coefficients instead of ICCs were used for the concurrent validity analysis.…”

Declínio cognitivo e demência associados à doença de Parkinson: características clínicas e tratamento

“…(Marinus et al, 2003) e o Teste MiniMental Parkinson (Mahieux et al, 1995) que foram elaborados com a intenção de se verificar os domínios cognitivos mais comumente afetados pela DP.…”