Minerals and Sarcopenia; The Role of Calcium, Iron, Magnesium, Phosphorus, Potassium, Selenium, Sodium, and Zinc on Muscle Mass, Muscle Strength, and Physical Performance in Older Adults: A Systematic Review

Dronkelaar, Carliene van; Velzen, Aafke van; Abdelrazek, Maya; Steen, Anouk van der; Weijs, P.J.M.; Tieland, Michael

doi:10.1016/j.jamda.2017.05.026

Cited by 189 publications

(157 citation statements)

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“…Previous studies support the role of dietary calcium and magnesium in skeletal muscle and overall physical functioning . Magnesium intake was associated with physical functioning, while both were associated with prevalence of sarcopenia .…”

Section: Discussionmentioning

confidence: 69%

“…These studies suggest that the influence of dietary magnesium on muscle mass and physical functioning may also be related to both age and previous exercise history. In addition, a recent meta‐analysis demonstrated that calcium intake is significantly associated with muscle mass in older adults …”

Section: Discussionmentioning

confidence: 99%

“…Second to calcium, magnesium is the most abundant divalent cation in the body and the nutrients can potentially antagonize each other in physiologic pathways, including skeletal muscle function . Studies demonstrate that circulating, extracellular calcium and magnesium levels may influence skeletal muscle function and potentially the quality of skeletal muscle, in addition to overall physical functioning . In turn, low dietary calcium and magnesium, or the balance between the two, may influence an individual's ability to engage in the recommended levels of moderate‐intensity physical activity, which may have significant effects on overall health and mortality .…”

Section: Introductionmentioning

confidence: 99%

“…In turn, low dietary calcium and magnesium, or the balance between the two, may influence an individual's ability to engage in the recommended levels of moderate‐intensity physical activity, which may have significant effects on overall health and mortality . However, no studies assessing the influence of dietary supplementation on muscle performance or physical functioning examined both nutrients . Moreover, while the evidence for the influence of magnesium on physical performance and health across the lifespan are inconsistent, the evidence for the importance of the Ca:Mg in overall health is growing …”

Section: Introductionmentioning

confidence: 99%

“…9,10 Studies demonstrate that circulating, extracellular calcium and magnesium levels may influence skeletal muscle function 11 and potentially the quality of skeletal muscle, in addition to overall physical functioning. 12,13 In turn, low dietary calcium and magnesium, or the balance between the two, may influence an individual's ability to engage in the recommended levels of moderate-intensity physical activity, which may have significant effects on overall health and mortality. 14,15 However, no studies assessing the influence of dietary supplementation on muscle performance or physical functioning examined both nutrients.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Physical activity, dietary calcium to magnesium intake and mortality in the National Health and Examination Survey 1999–2006 cohort

Hibler

Zhu

Shrubsole

et al. 2019

Intl Journal of Cancer

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Calcium and magnesium affect muscle mass and function. Magnesium and calcium are also important for optimal vitamin D status. Vitamin D status modifies the associations between physical activity and risk of incident cardiovascular disease (CVD) and CVD mortality. However, no study examined whether levels of magnesium and calcium and the ratio of dietary calcium to magnesium (Ca:Mg) intake modify the relationship between physical activity and mortality. We included 20,295 National Health and Nutrition Examination Survey participants (1999–2006) aged >20 years with complete dietary, physical activity and mortality data (2,663 deaths). We assessed physical activity based on public health guidelines and sex‐specific tertiles of MET‐minutes/week. We used Cox proportional hazards models adjusted for potential confounding factors and stratified by the intakes of magnesium, calcium, Ca:Mg ratio. We found higher physical activity was significantly associated with reduced risk of total mortality and cause‐specific mortality, regardless of Ca:Mg ratio, magnesium or calcium intake. In contrast, both moderate and high physical activity were significantly associated with substantially reduced risks of mortality due to cancer when magnesium intake was above the RDA level. We also found higher physical activity was significantly associated with a reduced risk of mortality due to cancer only when Ca:Mg ratios were between 1.7 and 2.6, although the interaction was not significant. Overall, dietary magnesium and, potentially, the Ca:Mg ratio modify the relationship between physical activity and cause‐specific mortality. Further study is important to understand the modifying effects of the balance between calcium and magnesium intake on physical activity for chronic disease prevention.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%