Mineralogical Microanalysis of Idiopathic Pulmonary Fibrosis

Monsó, Eduard; Tura, J M; Marsal, M.; Morell, Ferrán; Pujadas, J; Morera, Josep

doi:10.1080/00039896.1990.9936714

Cited by 46 publications

(31 citation statements)

References 9 publications

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“…Considering that the right lung is more frequently involved by pneumoconiosis [9], it is likely that DIF represents a dust-related disorder. There are reports in the literature, documenting cases of DIF associated with a burden of various metals [10][11][12][13][14], nonasbestos particulate matters [15,16] or amorphous sil ica [17,18], On the other hand, a possible pathogenetic link with idiopathic pulmonary fibrosis or cryptogenic fibros ing alveolitis may also be suggested [19][20][21]. 124 H onma/Chiyotani Pneum oconiotic Diffuse Interstitial Fibrosis Our data demonstrate that DIF tends to develop more frequently in elderly subjects with longer occupational his tories.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Interstitial Fibrosis in Nonasbestos Pneumoconiosis – A Pathological Study

Honma

Chiyotani

1993

Respiration

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Pathological examinations of 233 consecutive autopsy cases with nonasbestos pneumoconiosis revealed evidence of diffuse interstitial fibrosis (DIF) in 64 (27.5%), among whom 45 (19.3%) showed bilateral involvement and 9 (3.9%) extensive disease closely resembling usual interstitial pneumonia. The patients with DIF were significantly older and had longer occupational histories as compared with those without DIF. There was no correlation between the occurrence of DIF and the type of the underlying disease (silicosis or mixed dust pneumoconiosis) except that an extensive DIF was more frequently associated with mixed dust pneumoconiosis. The extensive DIF developed an in situ malignancy much more frequently (33.3%) than the focal disease (2.6%).

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Section: Discussionmentioning

confidence: 99%

Diffuse Interstitial Fibrosis in Nonasbestos Pneumoconiosis – A Pathological Study

Honma

Chiyotani

1993

Respiration

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“…cates) in lung tissue of some patients with a diagnosis of IPF (5), and three case-control studies have reported an elevated risk for subjects exposed to metal dust (6)(7)(8). Wood dust exposure was reported to be significantly associated with the development of IPF in one of these case-control studies (8).…”

mentioning

confidence: 97%

Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis.

Baumgartner

Samet²,

Stidley³

et al. 1997

Am J Respir Crit Care Med

653

386

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We conducted a multicenter case-control study of clinically and histologically diagnosed idiopathic pulmonary fibrosis (IPF), a chronic diffuse interstitial lung disease of unknown cause. The study included 248 cases, and 491 control subjects identified through random-digit dialing, matched to cases in sex, age, and geographic region. Telephone interviews were conducted with both cases and controls to collect information on potential risk factors for IPF, including smoking and household, occupational, and environmental exposures. Pulmonary function tests, X-rays, computed tomographic (CT) scans of the chest, and lung biopsy reports were submitted by referring centers to support the diagnoses. An a priori hypothesis that smoking is associated with IPF was examined with conditional logistic regression analyses. More cases (72%) than control subjects (63%) had a history of ever smoking. The odds ratio (OR) for ever smoking was 1.6 (95% CI: 1.1 to 2.4). Risk was significantly elevated for former smokers (OR = 1.9; 95% CI: 1.3 to 2.9) and for smokers with 21 to 40 pack-yr (OR = 2.3; 95% CI: 1.3 to 3.8). A history of smoking is associated with an increased risk for the development of IPF. Although there was no clear exposure-response pattern with cumulative consumption of cigarettes, there was a trend for time since cessation of smoking, with the highest risk for those who had most recently quit.

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Section: Usual Interstitial Pneumonia: Occupational and Other Risk Famentioning

confidence: 99%

“…An excess of silica, and metals, including iron and nickel, has been reported in several studies [18–20]. Using scanning electron microscopy and energy dispersive X-ray analysis, Monso et al [20] reported elevated surface silica to sulfur ratios among six IPF patients compared to controls. Postulating that exposures may be concentrated in lymph nodes, a recent Japanese study of 23 IPF cases versus 23 controls demonstrated an excess of silicon and aluminum in the pulmonary hilar lymph nodes [21].…”

Section: Usual Interstitial Pneumonia: Occupational and Other Risk Famentioning

confidence: 99%

Asbestosis and environmental causes of usual interstitial pneumonia

Gulati

Redlich²

2015

Current Opinion in Pulmonary Medicine

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Purpose of review Recent epidemiologic investigations suggest that occupational and environmental exposures contribute to the overall burden of idiopathic pulmonary fibrosis (IPF). This article explores the epidemiologic and clinical challenges to establishing exposure associations, the current literature regarding exposure disease relationships and the diagnostic work-up of IPF and asbestosis patients. Recent findings IPF patients demonstrate a histopathologic pattern of usual interstitial pneumonia. In the absence of a known cause or association, a usual interstitial pneumonia pattern leads to an IPF diagnosis, which is a progressive and often terminal fibrotic lung disease. It has long been recognized that asbestos exposure can cause pathologic and radiographic changes indistinguishable from IPF. Several epidemiologic studies, primarily case control in design, have found that a number of other exposures that can increase risk of developing IPF include cigarette smoke, wood dust, metal dust, sand/silica and agricultural exposures. Lung mineralogic analyses have provided additional support to causal associations. Genetic variation may explain differences in disease susceptibility among the population. Summary An accumulating body of literature suggests that occupational and environmental exposure can contribute to the development of IPF. The impact of exposure on the pathogenesis and clinical course of disease requires further study.

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Mineralogical Microanalysis of Idiopathic Pulmonary Fibrosis

Cited by 46 publications

References 9 publications

Diffuse Interstitial Fibrosis in Nonasbestos Pneumoconiosis – A Pathological Study

Diffuse Interstitial Fibrosis in Nonasbestos Pneumoconiosis – A Pathological Study

Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis.

Asbestosis and environmental causes of usual interstitial pneumonia

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