2015
DOI: 10.1096/fj.15-276782
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Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target

Abstract: Early treatment with heart failure drugs lisinopril and spironolactone improves skeletal muscle pathology in Duchenne muscular dystrophy (DMD) mouse models. The angiotensin converting enzyme inhibitor lisinopril and mineralocorticoid receptor (MR) antagonist spironolactone indirectly and directly target MR. The presence and function of MR in skeletal muscle have not been explored. MR mRNA and protein are present in all tested skeletal muscles from both wild-type mice and DMD mouse models. MR expression is cell… Show more

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Cited by 47 publications
(73 citation statements)
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“…Snap frozen mouse tissues were pulverized and resuspended in cellular extract buffer as described previously [7]. Briefly, tissue homogenates were sonicated on ice, centrifuged, and total protein was quantified.…”
Section: Methodsmentioning
confidence: 99%
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“…Snap frozen mouse tissues were pulverized and resuspended in cellular extract buffer as described previously [7]. Briefly, tissue homogenates were sonicated on ice, centrifuged, and total protein was quantified.…”
Section: Methodsmentioning
confidence: 99%
“…Surprisingly, a combination treatment with the angiotensin-converting enzyme inhibitor (ACEi) lisinopril and the mineralocorticoid receptor (MR) antagonist spironolactone, led to improved function and pathology not only in the heart, but also in skeletal muscles [6]. We then showed that mineralocorticoid receptors, not previously investigated in skeletal muscles, were present in limb and respiratory muscles from wild-type and dystrophic mice [7]. The endogenous mineralocorticoid receptor agonist aldosterone was able to induce a large number of gene expression changes in normal human differentiated myotubes, supporting MR functions as a steroid hormone receptor in skeletal muscles.…”
Section: Introductionmentioning
confidence: 99%
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“…The recent study shows the presence and the activity of the mineralocorticoid receptor (MR) in skeletal muscle [9]. MR and GR exhibit cross-reactivity with endogenous GCs, which have the same or even higher affinity to MR than GR (depending on the tissue).…”
Section: Introductionmentioning
confidence: 99%
“…MR and GR exhibit cross-reactivity with endogenous GCs, which have the same or even higher affinity to MR than GR (depending on the tissue). As a consequence of the high homology with GR, MR is activated by both mineralocorticoids (aldosterone, deoxycorticosterone) and GCs [9]. Data from the past several years have assigned a specific role for the MR in mediating oxidative stress development.…”
Section: Introductionmentioning
confidence: 99%