Mineralocorticoid receptor haplotype, estradiol, progesterone and emotional information processing

Hamstra, D.A.; Kloet, E. Ronald de; Quataert, Ina; Jansen, Myrthe; Does, Willem Van der

doi:10.1016/j.psyneuen.2016.11.037

Cited by 37 publications

(26 citation statements)

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“…While investigating the effects of a corticosteroid (fludrocortisone) in a clinical trial, Hamstra et al ( 2014 ) found that the use of oral contraceptives by women in their sample was associated with lower accuracy in the recognition of sadness, anger, and disgust. Four other cross-sectional studies reached the same results for the same emotions when comparing users of oral contraceptives and women in their natural menstrual cycle (Maner and Miller, 2014 ; Hamstra et al, 2015 , 2016 , 2017 ), although another investigation with the same methodological design did not support these findings (Radke and Derntl, 2016 ). Hamstra et al ( 2017 ) also described impaired recognition of facial happiness in association with the use of oral contraceptives.…”

Section: Discussionmentioning

confidence: 74%

“…Group 2—Oral contraceptives: studies with women using oral contraceptives, taking women at different phases of the natural menstrual cycle as a reference, with both observational ( n = 5) (Maner and Miller, 2014 ; Hamstra et al, 2015 , 2016 , 2017 ; Radke and Derntl, 2016 ) and experimental ( n = 2) (Gingnell et al, 2013 ; Hamstra et al, 2014 ) designs.…”

Section: Resultsmentioning

confidence: 99%

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Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review

et al. 2018

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Background: We systematically reviewed the literature to determine the influence of sex hormones on facial emotion processing (FEP) in healthy women at different phases of life.Methods: Searches were performed in PubMed, Web of Science, PsycINFO, LILACS, and SciELO. Twenty-seven articles were included in the review and allocated into five different categories according to their objectives and sample characteristics (menstrual cycle, oral contraceptives, pregnancy/postpartum, testosterone, and progesterone).Results: Despite the limited number of studies in some categories and the existence of inconsistencies in the results of interest, the findings of the review suggest that FEP may be enhanced during the follicular phase. Studies with women taking oral contraceptives showed reduced recognition accuracy and decreased responsiveness of different brain structures during FEP tasks. Studies with pregnant women and women in the postpartum showed that hormonal changes are associated with alterations in FEP and in brain functioning that could indicate the existence of a hypervigilant state in new and future mothers. Exogenous administration of testosterone enhanced the recognition of threatening facial expressions and the activation of brain structures involved in the processing of emotional stimuli.Conclusions: We conclude that sex hormones affect FEP in women, which may have an impact in adaptive processes of the species and in the onset of mood symptoms associated with the premenstrual syndrome.

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Section: Discussionmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review

et al. 2018

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“…This stress-induced shift in strategy use, was absent in noncarriers of the MR haplotype (χ 2 (1) = 0.643, p = 0.423, Cramer’s V = 0.106). Since previous animal studies suggested that MR genotype effects may be sex-dependent ( Klok et al, 2011 ; Vinkers et al, 2015 ; Hamstra et al, 2017 ), we performed explorative analyses on our behavioral data, adding sex as another variable in the χ 2 test. Results indicate that in males, MR haplotype carriers use more multi-cue strategies after stress compared to the no-stress control condition (χ 2 (1) = 5.792, p = 0.016, Cramer’s V = 0.255), whereas in females, there was no significant modulation of strategy use under stress by the MR haplotype (χ 2 (1) = 2.091, p = 0.148, Cramer’s V = 0.154).…”

Section: Resultsmentioning

confidence: 99%

“…Determining how exactly a genetic variation in the MR gene translates into a more pronounced bias toward habit learning under stress remains a challenge for future molecular studies. Importantly, future studies will need to investigate additive gene dose-dependent effects of the MR haplotype ( Hamstra et al, 2017 ) as well as sex-dependent effects ( Vinkers et al, 2015 ). In particular, explorative analyses of the behavioral data of our first experiment lent some support for sex-dependent differences in the interactive influence of stress and MR genotype on the engagement of multiple learning strategies.…”

Section: Discussionmentioning

confidence: 99%

A Haplotype Associated with Enhanced Mineralocorticoid Receptor Expression Facilitates the Stress-Induced Shift from “Cognitive” to “Habit” Learning

Wirz

Reuter

Wacker

et al. 2017

eNeuro

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Stress induces a shift from hippocampus-dependent “cognitive” toward dorsal striatum-dependent “habit” memory. However, not all individuals are susceptible to this shift under stress. Based on pharmacological studies indicating a critical role of the mineralocorticoid receptor (MR) in the stress-induced bias toward dorsal striatal learning, we hypothesized that MR gene variants contribute to these individual differences. In two experiments, healthy participants were genotyped, exposed to a stressor or control manipulation and performed a learning task that can be solved using hippocampal or dorsal striatal systems, while electroencephalography (EEG; Experiment I) or functional magnetic resonance imaging (fMRI; Experiment II) measurements were taken. Stress led to a shift from hippocampal to dorsal striatal learning which was more pronounced in homo- and heterozygous carriers of a six single nucleotide polymorphisms (SNPs)-comprising haplotype containing the alleles of two MR SNPs associated with increased MR expression and transactivational activity (MR-2G/C C [rs2070951], MR-I180V A [rs5522]). This stress-induced shift toward habit memory was paralleled by an increased feedback-related negativity (FRN), which may reflect striatal processing, and increased caudate activation. Carriers of the MR haplotype showed a reduced P3a, an event-related potential thought to indicate cognitive processing, and reduced hippocampal activity after stress. Moreover, stress resulted in reduced amygdala-hippocampus connectivity and the decrease in amygdala connectivity to the parahippocampal cortex was particularly pronounced in MR haplotype carriers. Our findings indicate that genetic variants associated with enhanced MR expression facilitate a stress-induced shift from hippocampal toward dorsal striatal learning, most likely via impaired hippocampal processing and reduced amygdala-hippocampus cross talk, allowing the dorsal striatum to guide behavior under stress.

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“…Hap 2 carriers appeared less sensitive to variations in female hormone exposure during the reproductive cycle and to the depressinogenic side effects of oral contraceptives. The MR genotype moderates the influence of oestrogen and progesterone on emotional information processing (Hamstra et al 2015(Hamstra et al , 2016(Hamstra et al , 2017. The MR gene variants were found to sex-dependently moderate the effect of early life trauma on vulnerability to depression in a population-based cohort (n = 665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (n = 1639).…”

Section: Common and Functional Mr Haplotypes Might Relate To The Extementioning

confidence: 99%

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The brain mineralocorticoid receptor: a saga in three episodes

Joëls

Kloet

2017

Journal of Endocrinology

118

109

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In 1968, Bruce McEwen discovered that 3 H-corticosterone administered to adrenalectomised rats is retained in neurons of hippocampus rather than those of hypothalamus. This discovery signalled the expansion of endocrinology into the science of higher brain regions. With this in mind, our contribution highlights the saga of the brain mineralocorticoid receptor (MR) in three episodes. First, the precloning era dominated by the conundrum of two types of corticosterone-binding receptors in the brain, which led to the identification of the high-affinity corticosterone receptor as the 'promiscuous' MR cloned in 1987 by Jeff Arriza and Ron Evans in addition to the classical glucocorticoid receptor (GR). Then, the post-cloning period aimed to disentangle the function of the brain MR from that of the closely related GR on different levels of biological complexity. Finally, the synthesis section that highlights the two faces of brain MR: Salt and Stress. 'Salt' refers to the regulation of salt appetite, and reciprocal arousal, motivation and reward, by a network of aldosterone-selective MR-expressing neurons projecting from nucleus tractus solitarii (NTS) and circumventricular organs. 'Stress' is about the limbic-forebrain nuclear and membrane MRs, which act as a switch in the selection of the best response to cope with a stressor. For this purpose, activation of the limbic MR promotes selective attention, memory retrieval and the appraisal process, while driving emotional expressions of fear and aggression. Subsequently, rising glucocorticoid concentrations activate GRs in limbic-forebrain circuitry underlying executive functions and memory storage, which contribute in balance with MR-mediated actions to homeostasis, excitability and behavioural adaptation.

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Mineralocorticoid receptor haplotype, estradiol, progesterone and emotional information processing

Cited by 37 publications

References 50 publications

Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review

Sex Hormones and Processing of Facial Expressions of Emotion: A Systematic Literature Review

A Haplotype Associated with Enhanced Mineralocorticoid Receptor Expression Facilitates the Stress-Induced Shift from “Cognitive” to “Habit” Learning

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The brain mineralocorticoid receptor: a saga in three episodes

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