Mineralo- and glucocorticoid effects on renal excretion of electrolytes

Campen, Thomas J.; Vaughn, Duke A.; Fanestil, Darrell D.

doi:10.1007/bf00663903

Cited by 54 publications

(33 citation statements)

References 26 publications

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“…It was noted earlier that when aldosterone has been found in previously reported studies to cause an acute kaliuresis, it has usually been in the context of either some degree of sodium-loading (33,35,36), or of potassium-depletion (18,29,30). For example, one recent report (35) found an absence of kaliuresis after acute aldosterone administration in animals receiving minimal amounts of sodium during clearance studies, which contrasted with a kaliuretic response if sodium was provided freely during the study as well as in the 24-h-period before study.…”

Section: Discussionmentioning

confidence: 99%

“…Although this phenomenon has been repeatedly documented using clearance techniques (16)(17)(18)(19)(20)(21), only limited information is available on the specific effect of glucocorticoids on tubular transport function (14). In particular, it is unknown whether these agents stimulate tubular potassium secretion directly, or whether the observed kaliuresis is secondary to their marked stimulant effect on glomerular filtration, sodium excretion, and urinary flow rate.…”

mentioning

confidence: 99%

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Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney.

Field¹,

Stanton²,

Giebisch³

1984

J. Clin. Invest.

131

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Abstract. To determine the specific effects on renal potassium transport of acute elevations in plasma aldosterone, dexamethasone, and potassium concentrations, we studied adrenalectomized rats prepared such that each factor could be varied independently. Clearance data alone could not be used to deduce the underlying tubular transport effects, however, since infusion of each of these agents was associated with a marked change in urinary flow rate, which may itself have influenced potassium excretion. We therefore used a technique of continuous microperfusion, in vivo, of single superficial distal tubules to evaluate potassium secretion at constant luminal flow rate during each experimental maneuver. Acute aldosterone infusion was associated with a 90% stimulation of potassium secretion by microperfused tubules. However, total kidney sodium excretion and urinary flow rate were markedly reduced, and these factors opposed the direct tubular action of aldosterone, resulting in no net change in the amount of potassium excreted into the final urine. Conversely, dexamethasone had no direct effect on potassium secretion by single microperfused tubules, but it caused a sharp increase in urinary flow and sodium excretion, and secondarily enhanced urinary potassium excretion by 50%. Hyperkalemia per se stimulated renal potassium excretion both via a direct tubular effect and by increasing urinary Portions of this study have been published previously in abstract form (1984. Kidney Int.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Differential acute effects of aldosterone, dexamethasone, and hyperkalemia on distal tubular potassium secretion in the rat kidney.

Field¹,

Stanton²,

Giebisch³

1984

J. Clin. Invest.

131

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“…This concept of differences between Na C and K C effects was developed by Campen et al (1983), who distinguished between glucocorticoid-and mineralocorticoid-induced kaliuresis. In adrenalectomised animals treated subcutaneously at time 0 and 2 .…”

Section: G P Vinson Mislabelling Of Docmentioning

confidence: 99%

“…The relatively poor activity of DOC on kaliuresis was adduced by Campen et al (1983) as evidence that DOC is a partial glucocorticoid agonist. Whether or not they were right to ascribe its sodium effects to mineralocorticoid receptor (MR) activation alone, and potassium effects to both GR and MR mediation, the relatively poor effect of DOC on K C relative to Na C does not seem to be adequately accounted for.…”

Section: G P Vinson Mislabelling Of Docmentioning

confidence: 99%

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

Vinson¹

2011

Journal of Endocrinology

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Over the 70 or so years since their discovery, there has been continuous interest and activity in the field of corticosteroid functions. However, despite major advances in the characterisation of receptors and coregulators, in some ways we still lack clear insight into the mechanism of receptor activation, and, in particular, the relationship between steroid hormone structure and function remains obscure. Thus, why should deoxycorticosterone (DOC) reportedly be a weak mineralocorticoid, while the addition of an 11b-hydroxyl group produces glucocorticoid activity, yet further hydroxylation at C18 leads to the most potent mineralocorticoid, aldosterone? This review aims to show that the field has been confused by the misreading of the earlier literature and that DOC, far from being relatively inactive, in fact has a wide range of activities not shared by the other corticoids. In contrast to the accepted view, the presence of an 11b-hydroxyl group yields, in corticosterone or cortisol, hormones with more limited functions, and also more readily regulated, by 11b-hydroxysteroid dehydrogenase. This interpretation leads to a more systematic understanding of structure-function relationships in the corticosteroids and may assist more rational drug design.

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“…Keeping with their physiologic function, GRs are differentially distributed www.intechopen.com along the kidney nephron. In vitro studies have implicated GRs in the regulation of ammoniagenesis, gluconeogenesis, GFR, Na-H exchange and Na-phosphate co-transport, all of which are proximal renal tubule processes (Baylis et al 1990;Boross et al 1986;Campen et al 1983;Freiberg et al 1982). Measurement of GRs in normal rat kidney cortical tubules enriched in proximal tubules yielded three to six fold higher GR content as compared to the distal tubules (Mishina et al 1981).…”

Section: Expression Of Gr In the Normal Kidneymentioning

confidence: 99%