Mineralizing angiopathy and minor head trauma

Squier, Waney; Mack, Julie

doi:10.1111/dmcn.12416

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The cause for mineralization in affected children is usually unknown. Squier and Mack[9] proposed that mineralized vessels have defective physiological contractility leading to alteration in their barrier properties leading to the thrombotic event. They have suggested that there is evidence to implicate pericytes derived from mesoderm with osteogenic properties for the mineralization.…”

Section: Discussionmentioning

confidence: 99%

Mineralizing angiopathy of lenticulostriate arteries with infantile basal ganglia infarct following minor head trauma: A case series

Baby¹,

Vinayan²,

Roy³

2019

Ann Indian Acad Neurol

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Acute arterial ischemic stroke after minor head trauma has been reported in the past, mostly in infants. Most of these affected children had basal ganglia infarct on imaging. Investigations for other etiologies of stroke were noncontributory in most of the cases. Thin-slice computed tomography scan may show mineralizing angiopathy of lenticulostriate arteries. We report a clinical series of four infants who presented with the classical features of this distinct clinico-radiological entity. Clinical characteristics and risk factors at the time of stroke were described in detail. The long-term outcome on standard antiplatelet therapy is reported. None of the children had stroke recurrence during follow-up. The current literature on this clinico-radiological syndrome is reviewed in detail. In the typical cases, extensive etiological workup may not be warranted.

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Section: Discussionmentioning

confidence: 99%

Mineralizing angiopathy of lenticulostriate arteries with infantile basal ganglia infarct following minor head trauma: A case series

Baby¹,

Vinayan²,

Roy³

2019

Ann Indian Acad Neurol

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“…It also predisposes them to vasospasm and thrombosis. 1 3 15 Thrombosis and subsequent vascular occlusion would account for some cases' relatively late onset of symptoms. 8 However, this mechanism cannot explain the immediate onset of symptoms in some patients, such as the one reported in this case study.…”

Section: Discussionmentioning

confidence: 99%

Basal Ganglia Stroke after Mild Traumatic Brain Injury in Mineralizing Lenticulostriate Vasculopathy

Yanes

Birriel²,

Rabelino

2023

Journal of Pediatric Neurology

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Although the association between basal ganglia (BG) stroke and mild traumatic brain injury (TBI) is well recognized, its association with lenticulostriate vasculopathy has only recently been described. We present the case of a 6-month-old female infant without personal or familiar relevant records who presented with left-sided hemiparesis and without altered consciousness after a mild TBI. An emergency computed tomography (CT) scan of the brain revealed bilateral linear calcifications along the course of the lenticulostriate arteries. Brain magnetic resonance imaging (MRI) revealed an ischemic lesion in the right BG and damage to the posterior limb of the right internal capsule. A few months after the ischemic event, the patient was asymptomatic. Given the clinical, radiological, and evolutionary characteristics of this group of patients, the term mineralizing angiopathy is proposed to define a specific clinical-imaging syndrome in infants who suffer a BG stroke after a mild TBI and present with the calcification of the lenticulostriate arteries.

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“…1,6,25 Previous reports demonstrated that age, recurrent stroke, amount of bleeding, and ischemic focus size are among the most important prognostic factors. [26][27][28]…”

Section: Discussionmentioning

confidence: 99%

Association of Cytomegalovirus Infection with Lenticulostriate Stroke After Mild Head Trauma in Young Children

et al. 2022

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The development of lenticulostriate stroke following mild head trauma accounts for 3% of traumatic brain injuries in children. Nevertheless, the pathogenesis of infantile lenticulostriate stroke with lenticulostriate calcification is poorly understood. In this study, we explored the association of a recent viral infection with the development of infantile lenticulostriate stroke with lenticulostriate calcification following mild head trauma in children. We examined the records for 49 children (<36 months old) diagnosed with infantile stroke following mild head trauma at the First Hospital of Jilin University between January 2007 and August 2019. The demographic characteristics, clinical manifestations, and laboratory and imaging results were collected and analyzed. Antibodies against Epstein-Barr virus, herpes simplex virus, and cytomegalovirus in the patient sera were assessed. A total of 18 patients with lenticulostriate stroke and calcification were included in the Patient group (16.61 ± 10.57 months), and 14 patients without calcification were included in the Control group (13.07 ± 7.66 months). Imaging findings demonstrated the presence of lenticulostriate stroke in all patients. There were no significant differences in the demographic characteristics or clinical manifestations of stroke between both groups ( P > .05). Similarly, no significant differences were observed in the Epstein-Barr virus and herpes simplex virus–1 antibody positivity in both groups. In contrast, cytomegalovirus antibody was significantly more abundant in the Patient group ( P < .05). All patients were hospitalized for conservative treatment with favorable prognoses. Our results suggest that cytomegalovirus infection may be associated with the development of lenticulostriate strokes in pediatric patients following minor head injury.

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Mineralizing angiopathy and minor head trauma

Cited by 4 publications

References 10 publications

Mineralizing angiopathy of lenticulostriate arteries with infantile basal ganglia infarct following minor head trauma: A case series

Mineralizing angiopathy of lenticulostriate arteries with infantile basal ganglia infarct following minor head trauma: A case series

Basal Ganglia Stroke after Mild Traumatic Brain Injury in Mineralizing Lenticulostriate Vasculopathy

Association of Cytomegalovirus Infection with Lenticulostriate Stroke After Mild Head Trauma in Young Children

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