Mineralized Collagen Modified Polymethyl Methacrylate Bone Cement for Osteoporotic Compression Vertebral Fracture at 1-Year Follow-up

Zhu, Jinjin; Zhang, Kai; Luo, Kefeng; Qiu, Zhiye; Yang, Shuhui; Cui, Fuzhai; Weng, Xisheng; Jiang, Guoqiang

doi:10.1097/brs.0000000000002971

Cited by 29 publications

(23 citation statements)

References 52 publications

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“…Both PKP and PVP are safe and effective surgical procedures for treating OVCFs [ 29 ]. However, in terms of restoring vertebral height and local kyphotic corrections, PKP is relatively better than PVP [ 30 ]. Studies of PKP have indicated that the procedure duration of PKP is short and this technique yields fewer cement leakages with better pain relief, improvements of ODI, and a trend towards a longer fracture-free survival [ 31 , 32 ].…”

Section: The Development Of Vertebral Augmentation Systemsmentioning

confidence: 99%

“…Currently, mineralized collagen-modified PMMA (MC-modified PMMA), a kind of new bone cement that does not change the beneficial properties of PMMA, has better biocompatibility than normal PMMA. It has been reported that this new bone cement forms a stable structure in the vertebral body as well as improves the prognosis of patients who have OVCFs by reducing pain and reoperation [ 30 ]. With the development of biomaterials, it is possible to obtain new types of bone cement with bioactivity, excellent biomechanics, and even osteogenesis and appropriate degeneration.…”

Section: The Development Of Vertebral Augmentation Systemsmentioning

confidence: 99%

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Advances in Vertebral Augmentation Systems for Osteoporotic Vertebral Compression Fractures

Long

Yang

2020

Pain Research and Management

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Osteoporotic vertebral compression fracture (OVCF) is a common cause of pain and disability and is steadily increasing due to the growth of the elderly population. To date, percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are almost universally accepted as appropriate vertebral augmentation procedures for OVCFs. There are many advantages of vertebral augmentation, such as short surgical time, performance under local anaesthesia, and rapid pain relief. However, there are certain issues regarding the utilization of these vertebral augmentations, such as loss of vertebral height, cement leakage, and adjacent vertebral refracture. Hence, the treatment for OVCF has changed in recent years. Satisfactory clinical results have been obtained worldwide after application of the OsseoFix System, the SpineJack System, radiofrequency kyphoplasty of the vertebral body, and the Kiva VCF treatment system. The following review discusses the development of the current techniques used for vertebral augmentation.

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Section: The Development Of Vertebral Augmentation Systemsmentioning

confidence: 99%

Section: The Development Of Vertebral Augmentation Systemsmentioning

confidence: 99%

Advances in Vertebral Augmentation Systems for Osteoporotic Vertebral Compression Fractures

Long

Yang

2020

Pain Research and Management

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“…However conservative treatment is usually not effective in relieving symptoms. PVP and PKP are highly effective in relieving pain and improve the prognosis of OVCF 20,21 . They have advantages including vertebral body formation, minimally invasive, rapid pain relief, quick recovery, and have been widely used in the treatment of OVCF.…”

Section: Clinical Research Progress Of Pvp In Treatment Of Ovcf and Cmentioning

confidence: 99%

Percutaneous Vertebroplasty with Side‐Opening Cannula or Front‐Opening Cannula in the Treatment of Kummell Disease?

Ping

Zeng

et al. 2020

Orthopaedic Surgery

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Objective To explore the effect of bone cement distribution, cement leakage, and clinical outcomes with side‐opening cannula for bone cement injection in percutaneous vertebroplasty (PVP) in treatment of Kummell disease. Methods A prospective study of patients with Kummell disease undergoing PVP was conducted from April 2012 to September 2017. In total, 43 patients (11 males, 32 females) with Kummell disease who received bilateral PVP were included in the study. The patients were divided into front‐opening cannulas (FOC) group with front‐opening cannulas and side‐opening cannulas (SOC) group with side‐opening cannulas. All patients were followed up for 6 months. The patient general information such as gender, age, bone density, compression ratio, operative time, and location of fracture vertebrae were recorded. Visual analogue scale (VAS), Oswestry Disability Index (ODI), bone cement distribution, radiation exposure time, bone cement leakage rate and vertebral height, and kyphosis angle were measured and compared for two groups before surgery, 1 day and 6 months after surgery. Results A total of 43 patients were enrolled, including 11 males and 32 females, aged 61–84 years. The bone density (T value) was 2.5 ± 0.6 in FOC group and 2.4 ± 0.6 in SOC group (P > 0.05). The compression ratio and operative time were 36.1% ± 13.0%, 39.3 ± 7.9 min in FOC group and 35.2% ± 13.7%, 40.0 ± 10.7 min in SOC group (P > 0.05). There was no significance between FOC and SOC groups in the location of fracture vertebrae. All patients underwent at least 6 months of follow‐up. At 6 months postoperatively, the VAS and ODI were significantly higher in the FOC group (3.0 ± 0.8, 35.7% ± 2.1%) than in the SOC group (1.3 ± 0.4, 18.6% ± 2.4%) (P < 0.05). The cement leakage rate of the SOC group was 4.8%, which was lower than that of the FOC group (31.8%, P < 0.05), and the bone cement distribution ratio was higher than that of the FOC group (63.1% ± 7.9% vs 40.5% ± 8.6%, P < 0.05). At 6 months after operation, the height of the anterior and posterior vertebral bodies of the patients in the SOC group restored better than the FOC group (anterior SOC: FOC 5.1 ± 0.5 mm vs 4.5 ± 0.5 mm; posterior SOC: FOC 0.6 ± 0.1 mm vs 0.3 ± 0.1 mm, P < 0.05), and the kyphosis correction was more obvious than patients in FOC group (SOC: FOC 8.5° ± 1.4° vs 4.6° ± 0.8°, P < 0.05). Conclusion Percutaneous vertebroplasty with side‐opening cannula is safe and effective in avoiding bone cement leakage, improving bone cement distribution, and restoring vertebral height.

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“…[28][29][30] Via the modification, bone formation at the interface between the bone cement and host bone could be observed, and secondary fracture was significantly decreased as shown by longterm follow-ups. [31][32][33] Although MC-modified PMMA bone cement has many advantages compared with traditional bone cement, it has not been used for interbody fusion. Moreover, an appropriate biomaterial and applicable operative method need to be developed.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive injectable lumbar interbody fusion with mineralized collagen-modified PMMA bone cement: A new animal model

Kong¹,

Ma²,

Wu³

et al. 2020

Journal of Applied Biomaterials & Functional Materials

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This study was to develop a feasible and safe animal model for minimally invasive injectable lumbar interbody fusion using a novel biomaterial, mineralized collagen-polymethylmethacrylate bone cement (MC-PMMA), with unilateral pedicle screw fixation in an in vivo goat model. Eight goats ( Capra aegagrus hircus) were divided into three groups: MC-PMMA, unmodified commercial-polymethylmethacrylate bone cement (UC-PMMA), and a control group (titanium cage filled with autogenous bone, TC-AB). Each group of goats was treated with minimally invasive lumbar interbody fusion at the L3/L4 and L5/L6 disc spaces (injected for MC-PMMA and UC-PMMA, implanted for TC-AB). The pedicle screws were inserted at the L3, L4, L5, and L6 vertebrae, respectively, and fixed on the left side. The characteristics of osteogenesis and bone growth were assessed at the third and the sixth month, respectively. The methods of evaluation included the survival of each animal, X-ray imaging, and 256-layer spiral computed tomography (256-CT) scanning, imaged with three-dimensional microfocus computed tomography (micro-CT), and histological analysis. The results showed that PMMA bone cement can be extruded smoothly after doping MC, the MC-PMMA integrates better with bone than the UC-PMMA, and all goats recovered after surgery without nerve damage. After 3 and 6 months, the implants were stable. New trabecular bone was observed in the TC-AB group. In the UC-PMMA group a thick fibrous capsule had formed around the implants. The MC-PMMA was observed to have perfect osteogenesis and bone ingrowth to adjacent bone surface. Minimally invasive injectable lumbar interbody fusion using MC-PMMA bone cement was shown to have profound clinical value, and the MC-PMMA showed potential application prospects.

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Mineralized Collagen Modified Polymethyl Methacrylate Bone Cement for Osteoporotic Compression Vertebral Fracture at 1-Year Follow-up

Cited by 29 publications

References 52 publications

Advances in Vertebral Augmentation Systems for Osteoporotic Vertebral Compression Fractures

Advances in Vertebral Augmentation Systems for Osteoporotic Vertebral Compression Fractures

Percutaneous Vertebroplasty with Side‐Opening Cannula or Front‐Opening Cannula in the Treatment of Kummell Disease?

Minimally invasive injectable lumbar interbody fusion with mineralized collagen-modified PMMA bone cement: A new animal model

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