Mineral-Vitamin Treatment Associated with Remission in Attention-Deficit/Hyperactivity Disorder Symptoms and Related Problems: 1-Year Naturalistic Outcomes of a 10-Week Randomized Placebo-Controlled Trial

Darling, Kathryn A; Eggleston, Matthew; Retallick-Brown, Hannah; Rucklidge, Julia J.

doi:10.1089/cap.2019.0036

Cited by 11 publications

(10 citation statements)

References 51 publications

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“…The participants in both RCTs were followed for one year after the study began. The results from both follow-ups were remarkably similar (Darling et al, 2019;Rucklidge et al, 2017). About 20% of the participants in both studies continued taking the nutrients, and were identified as having better mental health than those who chose to stop taking the nutrients or who switched to medications.…”

Section: Adhdmentioning

confidence: 74%

Nutrition Provides the Essential Foundation for Optimizing Mental Health

Rucklidge

Johnstone

Kaplan

2021

Evidence-Based Practice in Child and Adolescent Mental Health

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Although current evidence confirms the importance of diet for mental health, many psychologists avoid discussing dietary intake with clients, questioning whether this information is within their scope of practice. This article provides psychologists with a review focused on the connection between what we eat and how we feel. Eating a healthy, whole-foods-based diet is an important tool to promote mental health recovery and maintenance. We begin by reviewing several mechanisms by which nutrients maximize brain health, including enabling metabolic reactions to occur, supporting mitochondrial function, reducing inflammation and assisting with detoxification. Understanding the vital role of nutrients for brain health will aid clients in understanding the importance of optimizing their intake of a range of nutrients in order to maximize their mental health: no single nutrient is sufficient. Next, we summarize evidence relating diet to mental health, followed by a consideration of circumstances that may contribute to a client requiring additional nutrients, such as chronic stress, medication use, individual biochemistry, and consuming nutrientdepleted food. The evidence base for treating psychological problems in children with supplementary nutrients is then reviewed, and a case study of a child whose self-regulatory skills improved with broad-spectrum multinutrients is used to illustrate this treatment. The breadth and consistency of the research highlights the importance of children receiving a good foundation of nutrients for optimizing brain health. Finally, we offer practical suggestions for psychologists to incorporate this information into their clinical practice and discuss these suggestions within the context of informed consent.

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Section: Adhdmentioning

confidence: 74%

Nutrition Provides the Essential Foundation for Optimizing Mental Health

Rucklidge

Johnstone

Kaplan

2021

Evidence-Based Practice in Child and Adolescent Mental Health

Self Cite

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“…These studies highlighted improvements in several behavioral, emotional, and cognitive ADHD symptoms. Furthermore, the follow-up study [62] offers additional evidences regarding possible efficacy of micronutrients mix. However, these studies are characterized by low numerosity and high heterogeneity of samples and treatments.…”

Section: Resultsmentioning

confidence: 99%

“…The only study concerning early-life probiotic supplementation revealed positive effects compared to placebo preventing ADHD onset later in life [71]. Studies regarding micronutrients mix supplementation found beneficial effects over placebo in general functioning, emotional dysregulation, aggression, and attention [59,61,62]. Importantly, a follow-up work by Rucklidge et al identified various factors related to response to treatment with micronutrients mix, such as lower pre-treatment folate and B12 levels, being female, greater severity of symptoms and co-occurring disorders in pre-treatment condition, more pregnancy complications, and fewer birth problems [63].…”

Section: Discussion Of Resultsmentioning

confidence: 99%

“…Several studies focused on broad combinations of vitamins and minerals [ 59 , 60 , 61 , 62 , 63 ] ( Table 1 d). One used a mixture of vitamin D and magnesium [ 60 ], two provided “daily essential nutrient formula”, which contained 13 vitamins, 17 minerals, and 4 amino acids [ 59 , 61 ].…”

Section: Resultsmentioning

confidence: 99%

“…One used a mixture of vitamin D and magnesium [60], two provided "daily essential nutrient formula", which contained 13 vitamins, 17 minerals, and 4 amino acids [59,61]. The remaining studies represent further analyses [63] and follow-up research [62] of the Rucklidge et al paper [61]. All studies were comprised of children with several comorbidities and applied equal randomization between groups.…”

Section: Methodologiesmentioning

confidence: 99%

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Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review

et al. 2020

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents, with environmental and biological causal influences. Pharmacological medication is the first choice in ADHD treatment; recently, many studies have concentrated on dietary supplementation approaches to address nutritional deficiencies, to which part of non-responses to medications have been imputed. This review aims to evaluate the efficacy of non-pharmacological supplementations in children or adolescents with ADHD. We reviewed 42 randomized controlled trials comprised of the following supplementation categories: polyunsaturated fatty acids (PUFAs), peptides and amino acids derivatives, single micronutrients, micronutrients mix, plant extracts and herbal supplementations, and probiotics. The reviewed studies applied heterogeneous methodologies, thus making it arduous to depict a systematic overview. No clear effect on single cognitive, affective, or behavioral domain was found for any supplementation category. Studies on PUFAs and micronutrients found symptomatology improvements. Peptides and amino acids derivatives, plant extracts, herbal supplementation, and probiotics represent innovative research fields and preliminary results may be promising. In conclusion, such findings, if confirmed through future research, should represent evidence for the efficacy of dietary supplementation as a support to standard pharmacological and psychological therapies in children and adolescents with ADHD.

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