Mineral distribution in the enamel of teeth with amelogenesis imperfecta as determined by quantitative microradiography

Bäckman, Birgitta; Angmar‐Månsson, Birgit

doi:10.1111/j.1600-0722.1994.tb01178.x

Cited by 6 publications

(12 citation statements)

References 15 publications

(13 reference statements)

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“…They stated that as one moves towards the DEJ, the Ca content falls more drastically than in healthy teeth, with the layer 30 µm from the junction having an extremely low Ca content. Contrary to our microhardness observations, Bäckman and Angmar-Mansson reported that the mineral distribution pattern, as assessed by qualitative microradiography, from the enamel surface to DEJ was similar in pitted hypoplastic AI and normal teeth [5]. However, the range for the mineral content per volume was similar to normal in only one of the four pitted hypoplastic AI teeth analyzed [5].…”

Section: Discussioncontrasting

confidence: 99%

“…Reports on the various forms of AI indicate that the hypocalcified type of enamel has a low volume percentage of minerals and that the lowest values are found in the bulk of the enamel [5]. As much as a 30% decrease in mineral content has been reported in this type of enamel [21].…”

Section: Discussionmentioning

confidence: 99%

“…According to Bäckman and Anneroth [6], in all types of AI, structural and mineral changes are present, whereas Wright and co-workers [8] reported that mineral content is reduced in hypomaturation and hypocalcified AI enamel, although in hypoplastic AI enamel, it varies from normal to reduced. Bäckman and Angmar-Mansson [5] also found that, compared to healthy enamel, especially the hypomineralized type of AI had reduced mineral content. The Witkop classification [3] uses the term hypocalcified and hypomaturation as subgroups of hypomineralized AI.…”

Section: Introductionmentioning

confidence: 88%

“…Analysis shows that in the majority of enamel samples with different AI phenotypes, there are different extents of hypomineralization and hypoplasia [4][5][6][7]. According to Bäckman and Anneroth [6], in all types of AI, structural and mineral changes are present, whereas Wright and co-workers [8] reported that mineral content is reduced in hypomaturation and hypocalcified AI enamel, although in hypoplastic AI enamel, it varies from normal to reduced.…”

Section: Introductionmentioning

confidence: 99%

“…The Witkop classification [3] uses the term hypocalcified and hypomaturation as subgroups of hypomineralized AI. Bäckman and Angmar-Mansson [5] have chosen to deviate from his terminology and categorize the hypocalcified phenotype as hypomineralized.…”

Section: Introductionmentioning

confidence: 99%

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Microhardness and microstructure of deciduous enamel with different types of amelogenesis imperfecta

Pavlič¹,

Skraba

Kosec

et al. 2007

Open Medicine

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AbstractAmelogenesis imperfecta (AI) is an inherited tooth disorder with widely varying phenotypes. The aim of this study was to determine the microhardness and microstructure characteristics of the enamel in AI teeth. The AI phenotypes examined were hypoplastic (pitted and smooth form), hypomaturated, and hypocalcified. Six AI patients were diagnosed according to clinical characteristics. The microhardness of the enamel was measured on axial cuts of AI teeth acquired from the patients. The measurements were done on several sites from the enamel surface towards the dentine-enamel junction using the Vickers scale. Values of microhardness were compared to corresponding control teeth. The microstructure of AI enamel types was evaluated using scanning electron microscopy. The values of microhardness in pitted hypoplastic AI samples were, on average, lower compared to the control enamel and dropped markedly towards the dentine-enamel junction. The smooth hypoplastic enamel was not only extremely thin but also much softer than control enamel. The values for hypomaturated AI fluctuated, but the palatal sites were markedly softer than in the control tooth. Hypocalcified enamel was the softest, with values resembling those of dentin. Microstructural changes varied from altered orientation of enamel prisms in pitted hypoplastic AI to lack of normal prismatic structure and severe porosity in hypocalcified AI. The present results suggest different microhardness profiles and microstructures in each phenotype. Variations among phenotypes are expected with larger case selection in this genetically heterogeneous disease.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Microhardness and microstructure of deciduous enamel with different types of amelogenesis imperfecta

Pavlič¹,

Skraba

Kosec

et al. 2007

Open Medicine

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Application of low‐wavenumber Raman spectroscopy to the analysis of human teeth

Bērziņš

Sutton

Loch

et al. 2019

J Raman Spectroscopy

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Low‐wavenumber Raman spectroscopy is demonstrated for its potential to analyse mineralization abnormalities in human teeth. Four different dental samples were analysed in this study, denoted as healthy control, mild hypomineralization, enamel caries, and AI (severely degraded due to Amelogenesis imperfecta). All specimens were imaged using principal component analysis. The spectra from low‐ wavenumber and midwavenumber regions were simultaneously collected allowing for direct comparison between the two regions. This approach provided a method to characterize structural and chemical variation within samples. Structurally different hydroxyapatite was found to be present in the surface and bulk of the enamel. The thin outer layer of the enamel contained the most structurally ordered mineral. The obtained Raman images enabled characterization and comparison of lesion domains as well as relative hydroxyapatite abundances across all dental samples.

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Inheritance Pattern and Elemental Composition of Enamel Affected by Hypomaturation Amelogenesis Imperfecta

Shore¹,

Bäckman²,

Brookes³

et al. 2002

Connective Tissue Research

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Hypomaturation amelogenesis imperfecta (AI) is characterized clinically by enamel of normal thickness that is hypomineralized, mottled, and detaches easily from the underlying dentin. Autosomal dominant, autosomal recessive, X-linked, and sporadic modes of inheritance have been documented. The present study investigated the elemental composition of the enamel of teeth from individuals demonstrating clinical hypomaturation AI from families representing three of these patterns of inheritance. The aim of the study was to determine if there was any commonality in microscopic phenotype of this defect between families demonstrating the various inheritance patterns. One section from each tooth was microradiographed and then viewed in a scanning electron microscope (SEM) equipped with an ultrathin window energy-dispersive x-ray spectroscopy (EDX) detector. In the SEM, prisms and constituent crystals in discrete areas appeared to be largely obscured by an amorphous material. EDX analysis showed enamel outside these areas to have a composition indistinguishable from control teeth. However, within these affected areas there was a large increase in carbon content (up to a fivefold increase). In some teeth there was also a detectable but smaller increase in the relative amounts of nitrogen or oxygen. The results suggest the defect in these teeth with a common clinical phenotype, irrespective of the pattern of inheritance, demonstrates a commonality in microscopic phenotype. The large increase in carbon content, not matched by an equivalent increase in nitrogen or oxygen, suggests a possible increased lipid content. In those teeth with elevated nitrogen levels there may also be retained protein.

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Mineral distribution in the enamel of teeth with amelogenesis imperfecta as determined by quantitative microradiography

Abstract: Bctckman B. Angmctr-Mans.wn B: Mineral distrihtttion in the enamel of teetli with aindogeitesis impeffecta as determined by quantitative microradiography. Scand J Dent Res 1994: 102: 193-197. © Munksgaard, 1994

Cited by 6 publications

References 15 publications

Microhardness and microstructure of deciduous enamel with different types of amelogenesis imperfecta

Microhardness and microstructure of deciduous enamel with different types of amelogenesis imperfecta

Application of low‐wavenumber Raman spectroscopy to the analysis of human teeth

Inheritance Pattern and Elemental Composition of Enamel Affected by Hypomaturation Amelogenesis Imperfecta

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