Mineral‐Coated Polymer Microspheres for Controlled Protein Binding and Release

Jongpaiboonkit, Leenaporn; Franklin-Ford, Travelle; Murphy, William L.

doi:10.1002/adma.200801808

Cited by 69 publications

(93 citation statements)

References 28 publications

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“…Such an approach was used to prepare CAP-coated PLLA microspheres with a sustained 30-day release profile of attached bovine serum albumin (BSA) in SBF compared with noncoated particles typified with an initial burst in the drug release. 349 An opposite approach, that is, coprecipitation of PLGA and a drug, tigecycline, in the presence of precursor HAP nanoparticles was recently implemented, resulting in HAP/PLGA/drug composite particles. 350 They turn out to be particularly appealing not only because of their biocompatible and biodegradable nature, but because HAP releases hydroxyl groups upon dissolution, whereas PLGA releases acidic products of degradation.…”

Section: Prospective Applicationsmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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The first part of this review looks at the fundamental properties of hydroxyapatite (HAP), the basic mineral constituent of mammalian hard tissues, including the physicochemical features that govern its formation by precipitation. A special emphasis is placed on the analysis of qualities of different methods of synthesis and of the phase transformations intrinsic to the formation of HAP following precipitation from aqueous solutions. This serves as an introduction to the second part and the main subject of this review, which relates to the discourse regarding the prospects of fabrication of ultrafine, nanosized particles based on calcium phosphate carriers with various therapeutic and/or diagnostic agents coated on and/or encapsulated within the particles. It is said that the particles could be either surface-functionalized with amphiphiles, peptides, proteins, or nucleic acids or injected with therapeutic agents, magnetic ions, or fluorescent molecules. Depending on the additive, they could be subsequently used for a variety of applications, including the controlled delivery and release of therapeutic agents (extracellularly or intracellularly), magnetic resonance imaging and hyperthermia therapy, cell separation, blood detoxification, peptide or oligonucleotide chromatography and ultrasensitive detection of biomolecules, and in vivo and in vitro gene transfection. Calcium phosphate nanoparticles as carriers of therapeutic agents that would enable a controlled drug release to treat a given bone infection and at the same be resorbed in the body so as to regenerate hard tissue lost to disease are emphasized hereby as one of the potentially attractive smart materials for the modern medicine.

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Section: Prospective Applicationsmentioning

confidence: 99%

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

2010

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“…Recently, PLGA microspheres with mineral coating using a biomimetic process for controlled protein binding and release were reported. [25] In this work, particles with an average size of 150 nm formulated using polyesters such as poly(lactic acid), PCL, and PLGA are employed as templates for the CaP mineralization. The concept of using nanoparticles in general as templates for mineralization have many advantages owing to their size and high-surface area.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

Ethirajan

Musyanovych

Landfester

2011

Macro Chemistry & Physics

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Biodegradable polymeric nanoparticles are employed as templates for the biomimetic mineralization of CaP in the aqueous phase. Particles in the sub‐µm range were prepared by a combination of solvent evaporation and miniemulsion techniques. The synthesized particles were subjected to degradation via random saponification. The anionic functional groups produced as a consequence of degradation due to production (ultrasonication step) and post treatment (hydrolysis) steps are used for the CaP mineralization. The composite particles were studied using HRSEM, TEM, and XRD. These polymer/CaP composite nanoparticles have a great potential to be used as a regenerative filler or as a scaffold for nucleation and growth of new bone material.

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“…[73] Other recent studies of HAP/polymer composites similarly show that the presence of HAP strongly influences protein release due to protein-mineral binding. [74,75] In addition, our recent work has demonstrated that HAP-coated polymer microspheres can be used as a carrier for controlled protein binding and release, [76] and these types of microspheres can be incorporated into hydrogels to create composite-controlled release systems for drug-delivery and tissue-engineering applications. [77] The variety of processing methods available for synthesis of HAP-containing materials, coupled with the ability of HAP to bind a broad range of acidic and basic biomolecules while maintaining biological activity, indicate that biomineral-protein interactions could have broad utility in affinity-based protein delivery.…”

Section: Materials For Affinity-mediated Protein Deliverymentioning

confidence: 99%

Bioinspired Design of Dynamic Materials

2009

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An emerging approach for design of dynamic materials involves mimicking natural systems, which are adept at changing their structure and function in response to their environment. Biological systems possess a diverse range of dynamic mechanisms, including competitive ligand–protein binding, enzyme‐catalyzed remodeling, and allosteric protein conformational changes. These dynamic mechanisms are now being exploited by materials scientists and engineers to design “bioinspired” synthetic materials that undergo responsive assembly and disassembly as well as dynamic volume and shape changes. The purpose of this review is to describe recent progress in design and development of bioinspired dynamic materials, with a particular emphasis on hydrogel networks. We specifically focus on emerging approaches that use biological phenomena as an inspiration for design of materials.

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Mineral‐Coated Polymer Microspheres for Controlled Protein Binding and Release

Cited by 69 publications

References 28 publications

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Nanosized hydroxyapatite and other calcium phosphates: Chemistry of formation and application as drug and gene delivery agents

Biodegradable Polymeric Nanoparticles as Templates for Biomimetic Mineralization of Calcium Phosphate

Bioinspired Design of Dynamic Materials

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