Mindfulness Training Reduces the Severity of Irritable Bowel Syndrome in Women: Results of a Randomized Controlled Trial

Gaylord, Susan; Palsson, Olafur S.; Garland, Eric L.; Faurot, Keturah R.; Coble, Rebecca; Mann, J. Douglas; Frey, William; Leniek, Karyn; Whitehead, William E.

doi:10.1038/ajg.2011.184

Cited by 234 publications

(192 citation statements)

References 44 publications

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“…The median short-term follow-up time was eight weeks (range 4-12 weeks). Figure 3.3 shows a positive effect of meditation on pain from 0-12 weeks in 17 studies (Brown and Jones, 2013;Cash et al, 2015;Cathcart et al, 2014;Esmer et al, 2010;Morone, Greco, and Weiner, 2008;Omidi and Zargar, 2014;Plews-Ogan et al, 2005;Teixeira, 2010;Wells et al, 2014;Zautra et al, 2008;Parra-Delgado and LatorrePostigo, 2013;Rahmani and Talepasand, 2015;Gaylord et al, 2011;Ljotsson, Falk, et al, 2010), which was statistically significant in five studies Omidi and Zargar, 2014;Wells et al, 2014;Rahmani and Talepasand, 2015;Gaylord et al, 2011). The pooled analysis of all 24 RCTs showed a significant positive effect (SMD 0.27; CI 0.04, 0.50; 24 RCTs; I 2 64.6%).…”

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 97%

“…Seven studies obtained a "good" quality rating Fogarty et al, 2015;Ljotsson, Falk, et al, 2010;Parra-Delgado and Latorre-Postigo, 2013;Zautra et al, 2008). Ten studies were judged to be of fair quality, primarily due to being unclear in some aspects of the methods (Cash et al, 2015;Davis and Zautra, 2013;Day et al, 2014;Dowd et al, 2015;Gaylord et al, 2011;la Cour and Petersen, 2015;Morone, Greco, and Weiner, 2008;Wells et al, 2014). Eleven studies were judged to be poor; eight of these were primarily due to issues with completeness of reporting outcome data, such as inadequate or missing ITT analysis or less than 80-percent follow-up Brown and Jones, 2013;Cathcart et al, 2014;Esmer et al, 2010;Meize-Grochowski et al, 2015;Morone et al, 2009;Omidi and Zargar, 2014;PlewsOgan et al, 2005).…”

Section: Study Quality/risk Of Bias For Individual Included Studiesmentioning

confidence: 99%

“…Pain scales and comparators varied from study to study (Astin et al, 2000;Brown and Jones, 2013;Cash et al, 2015;Cathcart et al, 2014;Davis and Zautra, 2013;Day et al, 2014;Dowd et al, 2015;Esmer et al, 2010;la Cour and Petersen, 2015;Meize-Grochowski et al, 2015;Morone, Greco, and Weiner, 2008;Morone et al, 2009;Omidi and Zargar, 2014;Plews-Ogan et al, 2005;Teixeira, 2010;Wells et al, 2014;Zautra et al, 2008;Parra-Delgado and Latorre-Postigo, 2013;Rahmani and Talepasand, 2015;Gaylord et al, 2011;Ljotsson, Falk, et al, 2010). The median follow-up time was 12 weeks, with a range of four to 60 weeks.…”

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

“…Eleven RCTs followed study participants more than 12 weeks (median: 20 weeks; range: 16-60 weeks) Cash et al, 2015;Dowd et al, 2015;Morone et al, 2009;Omidi and Zargar, 2014;Parra-Delgado and Latorre-Postigo, 2013;Rahmani and Talepasand, 2015;Gaylord et al, 2011). Figure 3.4 shows that there is an effect of meditation on pain for participants in six of these studies but not overall (SMD 0.37; C −0.01, 0.74; 11 RCTs, I 2 74.7%) Omidi and Zargar, 2014;Parra-Delgado and Latorre-Postigo, 2013;Rahmani and Talepasand, 2015;Gaylord et al, 2011). Substantial heterogeneity was detected.…”

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

“…Nonsignificance persisted when poor quality studies were dropped from analysis (SMD 0.11; CI −0.10, 0.32; 6 RCTs; I 2 0%; not displayed). Eight RCTs examined the effect of mindfulness meditation on pain compared with education or support groups Davis and Zautra, 2013;Dowd et al, 2015;Morone et al, 2009;Gaylord et al, 2011;Ljotsson, Falk, et al, 2010;Zautra et al, 2008) (see Figure 3.7). The effect of meditation was significant in three of these studies, and not significant when studies were pooled (SMD 0.19; CI −0.11, 0.49; 8 RCTs; I 2 63.9%) Gaylord et al, 2011;Ljotsson, Falk, et al, 2010).…”

Section: Comparatorsmentioning

confidence: 99%

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Mindfulness Meditation for Chronic Pain: A Systematic Review

Maglione¹,

Hempel²,

Maher³

et al. 2016

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Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 97%

Section: Study Quality/risk Of Bias For Individual Included Studiesmentioning

confidence: 99%

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

Section: Comparatorsmentioning

confidence: 99%

See 3 more Smart Citations

Mindfulness Meditation for Chronic Pain: A Systematic Review

Maglione¹,

Hempel²,

Maher³

et al. 2016

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Meditation Programs for Psychological Stress and Well-being

et al. 2014

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IMPORTANCEMany people meditate to reduce psychological stress and stress-related health problems. To counsel people appropriately, clinicians need to know what the evidence says about the health benefits of meditation.OBJECTIVE To determine the efficacy of meditation programs in improving stress-related outcomes (anxiety, depression, stress/distress, positive mood, mental health-related quality of life, attention, substance use, eating habits, sleep, pain, and weight) in diverse adult clinical populations.EVIDENCE REVIEW We identified randomized clinical trials with active controls for placebo effects through November 2012 from MEDLINE, PsycINFO, EMBASE, PsycArticles, Scopus, CINAHL, AMED, the Cochrane Library, and hand searches. Two independent reviewers screened citations and extracted data. We graded the strength of evidence using 4 domains (risk of bias, precision, directness, and consistency) and determined the magnitude and direction of effect by calculating the relative difference between groups in change from baseline. When possible, we conducted meta-analyses using standardized mean differences to obtain aggregate estimates of effect size with 95% confidence intervals.FINDINGS After reviewing 18 753 citations, we included 47 trials with 3515 participants. Mindfulness meditation programs had moderate evidence of improved anxiety (effect size, 0.38 [95% CI, 0.12-0.64] at 8 weeks and 0.22 [0.02-0.43] at 3-6 months), depression (0.30 [0.00-0.59] at 8 weeks and 0.23 [0.05-0.42] at 3-6 months), and pain (0.33 [0.03-0.62]) and low evidence of improved stress/distress and mental health-related quality of life. We found low evidence of no effect or insufficient evidence of any effect of meditation programs on positive mood, attention, substance use, eating habits, sleep, and weight. We found no evidence that meditation programs were better than any active treatment (ie, drugs, exercise, and other behavioral therapies). CONCLUSIONS AND RELEVANCEClinicians should be aware that meditation programs can result in small to moderate reductions of multiple negative dimensions of psychological stress. Thus, clinicians should be prepared to talk with their patients about the role that a meditation program could have in addressing psychological stress. Stronger study designs are needed to determine the effects of meditation programs in improving the positive dimensions of mental health and stress-related behavior.

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Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care

et al. 2022

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IMPORTANCE Successful treatment of opioid misuse among people with chronic pain has proven elusive. Guidelines recommend nonopioid therapies, but the efficacy of mindfulness-based interventions for opioid misuse is uncertain.OBJECTIVE To evaluate the efficacy of Mindfulness-Oriented Recovery Enhancement (MORE) for the reduction of opioid misuse and chronic pain. DESIGN, SETTING, AND PARTICIPANTSThis interviewer-blinded randomized clinical trial enrolled patients from primary care clinics in Utah between January 4, 2016, and January 16, 2020. The study included 250 adults with chronic pain receiving long-term opioid therapy who were misusing opioid medications. INTERVENTIONS Treatment with MORE (comprising training in mindfulness, reappraisal, and savoring positive experiences) or supportive group psychotherapy (control condition) across 8 weekly 2-hour group sessions.MAIN OUTCOMES AND MEASURES Primary outcomes were (1) opioid misuse assessed by the Drug Misuse Index (self-report, interview, and urine screen) and ( 2) pain severity and pain-related functional interference, assessed by subscale scores on the Brief Pain Inventory through 9 months of follow-up. Secondary outcomes were opioid dose, emotional distress, and ecological momentary assessments of opioid craving. The minimum intervention dose was defined as 4 or more completed sessions of MORE or supportive group psychotherapy. RESULTS Among 250 participants (159 women [63.6%]; mean [SD] age, 51.8 [11.9] years), 129 were randomized to the MORE group and 121 to the supportive psychotherapy group. Overall, 17 participants (6.8%) were Hispanic or Latino, 218 (87.2%) were White, and 15 (6.0%) were of other races and/or ethnicities (2 American Indian, 3 Asian, 1 Black, 2 Pacific Islander, and 7 did not specify). Atbaseline,themeandurationofpainwas14.7years(range,1-60years),andthemean(SD)morphineequivalent opioid dose was 101.0 (266.3) mg (IQR, 16.0-90.0 mg). A total of 203 participants (81.2%) received the minimum intervention dose (mean [SD], 5.7 [2.2] sessions); at 9 months, 92 of 250 participants (36.8%) discontinued the study. The overall odds ratio for reduction in opioid misuse through the 9-month follow-up period in the MORE group compared with the supportive psychotherapygroupwas2.06(95%CI,1.17-3.61;P = .01).At9months,36of80participants(45.0%) in the MORE group were no longer misusing opioids compared with 19 of 78 participants (24.4%) in the supportive psychotherapy group. Mixed models demonstrated that MORE was superior to supportive psychotherapy through 9 months of follow-up for pain severity (between-group effect: 0.49; 95% CI, 0.17-0.81; P = .003) and pain-related functional interference (between-group effect: 1.07; 95% CI, 0.64-1.50; P < .001). Participants in the MORE group reduced their opioid dose to a greater extent than those in the supportive psychotherapy group. The MORE group also had lower emotional distress and opioid craving. CONCLUSIONS AND RELEVANCEIn this randomized clinical trial, among adult participants in a primary care setting, t...

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Mindfulness Training Reduces the Severity of Irritable Bowel Syndrome in Women: Results of a Randomized Controlled Trial

Abstract: This randomized controlled trial demonstrated that mindfulness training has a substantial therapeutic effect on bowel symptom severity, improves health-related quality of life, and reduces distress. The beneficial effects persist for at least 3 months after group training.

Cited by 234 publications

References 44 publications

Mindfulness Meditation for Chronic Pain: A Systematic Review

Mindfulness Meditation for Chronic Pain: A Systematic Review

Meditation Programs for Psychological Stress and Well-being

Mindfulness-Oriented Recovery Enhancement vs Supportive Group Therapy for Co-occurring Opioid Misuse and Chronic Pain in Primary Care

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