Mindfulness-based therapy modulates default-mode network connectivity in patients with opioid dependence

Fahmy, Reham; Wasfi, Maha; Mamdouh, Rania; Moussa, Kareem; Wahba, Ahmed; Schmitgen, Mike M.; Kubera, Katharina M.; Wolf, Nadine D.; Sambataro, Fabio

doi:10.1016/j.euroneuro.2019.03.002

Cited by 17 publications

(37 citation statements)

References 57 publications

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“…In contrast to our hypothesis and previous brain imaging studies on the effect of mindfulness, 37,38,59 we did not find a significant time × condition interaction effect within portions of the DMN. This might be because of the small sample size, as we did see a trend toward reduced connectivity in the DMN in the MBI condition compared with the control condition.…”

Section: Discussioncontrasting

confidence: 99%

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Gucht

Ahmadoun

Melis

et al. 2020

Cancer

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Background Many breast cancer survivors suffer from cognitive complaints after cancer treatment, affecting their quality of life. The objective of this pilot study was to investigate the effect of a blended‐care mindfulness‐based intervention (MBI) on chemotherapy‐related cognitive impairment and functional brain changes. Furthermore, correlations between changes in cognitive functioning and self‐reported behavioral factors were investigated. Methods Breast cancer survivors (n = 33) who reported cognitive impairment were randomly allocated to a mindfulness condition (n = 18) or a waitlist control condition (n = 15). Patients completed questionnaires on cognitive impairment, emotional distress, and fatigue; neuropsychological tests; and resting‐state functional magnetic resonance imaging before the start of MBI (time 1 [T1]), immediately after the completion of an 8‐week MBI program (T2), and 3 months postintervention (T3). Resting‐state functional connectivity was estimated in the default mode network, the dorsal and salience attention networks, and the frontoparietal network. Mixed model repeated‐measures analysis was performed to test the intervention effect. Results Patients in the mindfulness condition exhibited significantly higher connectivity between the dorsal and salience attention networks after the mindfulness intervention compared with those in the control condition. MBI participants also had reduced subjective cognitive impairment, emotional distress, and fatigue. No intervention effect was observed on neurocognitive tests. Conclusions MBI may induce functional brain changes in networks related to attention and may have a positive effect on subjective measures of cognitive impairment in breast cancer survivors. Therefore, MBI could be a suitable intervention to improve quality of life in this population and deserves further study in this context.

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Section: Discussioncontrasting

confidence: 99%

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Gucht

Ahmadoun

Melis

et al. 2020

Cancer

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“…SBM takes advantage of independent component analysis to extract maximally independent spatial patterns of neural activity across the whole sample. We have previously applied SBM to structural data to investigate treatment‐related neural effects in patients with depression (Wolf et al, 2016), as well as in individuals with substance‐use disorders (Fahmy et al, 2019), where SBM has been shown to be sensitive to functional network strength changes. SBM has also been used previously on functional imaging data, including SPECT (Premi et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

Oxytocin modulates intrinsic neural activity in patients with chronic low back pain

Schneider

Schmitgen

Boll

et al. 2020

European Journal of Pain

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Eur J Pain. 2020;24:945-955. | 945 wileyonlinelibrary.com/journal/ejpThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to investigate the effects of intranasally applied OXT on intrinsic neural activity in patients with chronic low back pain (cLBP). Methods: Twenty-four male patients with cLBP and 23 healthy males were examined using resting-state functional magnetic resonance imaging. Participants were scanned twice and received either intranasally applied OXT (24 international units) or placebo 40 min before scanning. The fractional amplitude of low-frequency fluctuations (fALFF) was computed to investigate regionally specific effects of OXT on intrinsic neural activity. In addition a multivariate statistical data analysis strategy was employed to explore OXT-effects on functional network strength. Results: Differential effects of OXT were observed in cLBP and healthy controls.FALFF decreased in left nucleus accumbens and right thalamus in cLBP and increased in right thalamus in healthy controls after OXT application compared to placebo. OXT also induced activity changes in bilateral thalamus, left caudate nucleus and right amygdala in cLBP. OXT was associated with increased medial frontal, parietal and occipital functional network strength, though this effect was not group-specific. Regression analyses revealed significant associations between left nucleus accumbens, left caudate nucleus and right amygdala with pain-specific psychometric scores in cLBP. Conclusions: These data suggest OXT-related modulation of regional activity and neural network strength in patients with cLBP and healthy controls. In patients, distinct regions of the pain matrix may be responsive to modulation by OXT. Significance: Our data suggest significant oxytocin-related modulation of intrinsic regional activity and neural network strength in patients with chronic low back pain and healthy controls. In patients, distinct regions of the pain matrix may be responsive to modulation by oxytocin. Therapeutic effects of oxytocin for improved pain treatment need to be further investigated. K E Y W O R D S chronic pain, fALFF, MRI, multivariate analysis, resting state, source-based morphometry SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section. How to cite this article: Schneider I, Schmitgen MM, Boll S, et al. Oxytocin modulates intrinsic neural activity in patients with chronic low back pain. Eur J Pain. 2020;24:945-955. https://doi.

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“…SBM decomposition of subjects-by-voxel data matrix results in spatial maps, which are the sources of covariance, and a mixing matrix that indicates the contribution for each subject for each source. We have previously applied SBM to structural data to investigate neural effects associated with electroconvulsive therapy in MDD (Wolf et al ., 2016), as well as effects of psychotherapy in patients with substance-use disorders (Fahmy et al ., 2019), where SBM has been shown to be sensitive to treatment related changes of neural network strength. This technique has also been used previously on functional imaging data, including SPECT (Premi et al ., 2017).…”

Section: Methodsmentioning

confidence: 99%

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

et al. 2019

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BackgroundCognitive impairment is a core feature of major depressive disorder (MDD). Cognitive remediation may improve cognition in MDD, yet so far, the underlying neural mechanisms are unclear. This study investigated changes in intrinsic neural activity in MDD after a cognitive remediation trial.MethodsIn a longitudinal design, 20 patients with MDD and pronounced cognitive deficits and 18 healthy controls (HC) were examined using resting-state functional magnetic resonance imaging. MDD patients received structured cognitive remediation therapy (CRT) over 5 weeks. The whole-brain fractional amplitude of low-frequency fluctuations was computed before the first and after the last training session. Univariate methods were used to address regionally-specific effects, and a multivariate data analysis strategy was employed to investigate functional network strength (FNS).ResultsMDD patients significantly improved in cognitive function after CRT. Baseline comparisons revealed increased right caudate activity and reduced activity in the left frontal cortex, parietal lobule, insula, and precuneus in MDD compared to HC. In patients, reduced FNS was found in a bilateral prefrontal system at baseline (p < 0.05, uncorrected). In MDD, intrinsic neural activity increased in right inferior frontal gyrus after CRT (p < 0.05, small volume corrected). Left inferior parietal lobule, left insula, left precuneus, and right caudate activity showed associations with cognitive improvement (p < 0.05, uncorrected). Prefrontal network strength increased in patients after CRT, but this increase was not associated with improved cognitive performance.ConclusionsOur findings support the role of intrinsic neural activity of the prefrontal cortex as a possible mediator of cognitive improvement following CRT in MDD.

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Mindfulness-based therapy modulates default-mode network connectivity in patients with opioid dependence

Cited by 17 publications

References 57 publications

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Effects of a mindfulness‐based intervention on cancer‐related cognitive impairment: Results of a randomized controlled functional magnetic resonance imaging pilot study

Oxytocin modulates intrinsic neural activity in patients with chronic low back pain

Cognitive remediation therapy modulates intrinsic neural activity in patients with major depression

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