Mindfulness-based intervention for prodromal sleep disturbances in older adults: Design and methodology of a randomized controlled trial

Black, David S.; O’Reilly, Gillian; Olmstead, Richard G.; Breen, Elizabeth C.; Irwin, Michael R.

doi:10.1016/j.cct.2014.06.013

Cited by 18 publications

(23 citation statements)

References 45 publications

(54 reference statements)

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“…Participants were a subsample from a larger trial that examined the efficacy of a MBI on sleep complaints. 11 Except for the six subjects described here, the remainder of the sample did not undergo brain scans. Participants were eligible for the study if they were >55 years old, spoke English, and experienced current sleep complaints (Pittsburg Sleep Quality Index >5), 12 and spoke English.…”

Section: Methodsmentioning

confidence: 99%

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Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxelbased Morphometry

Kurth

Lüders

Wu³

et al. 2014

Neuro Open J

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BackgroundMindfulness-based interventions (MBIs) have previously been associated with structural gray matter changes in normal healthy adults. However, it remains unknown if standardized MBIs can induce similar changes in older adults and those with health complaints as well. The objective of this investigation was to examine the effect of a standardized MBI on the gray matter tissue of older adults with sleep disturbances.MethodsThis exploratory single-group pilot longitudinal study examined local gray matter changes over a six-week MBI period. Participants included six older adult community volunteers (M=66.5 years of age, SD=5.5, range=58–75; 66% female) with sleep disturbances recruited through advertisement in local newspapers/flyers posted at a university medical center and affiliated clinics in Los Angeles, CA. The MBI was delivered as a weekly, two-hour, six-session, group-based course in mindfulness meditation. Gray matter was measured voxel-wise pre- and post-intervention.ResultsA significant gray matter increase was identified within the precuneus, possibly implicating meditation-induced changes of the default mode network. In contrast, observed significant gray matter decreases may have been driven by MBI-related remediation of brain architecture subserving sleep complaints.ConclusionsExploratory findings suggest that mindfulness meditation practice is associated with a detectable alteration of cerebral gray matter in older adults.

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Section: Methodsmentioning

confidence: 99%

“…Participants are also provided with a book on mindfulness accompanied by a guided meditation CD for personal use (see Ref. 11 for more intervention details). Mindfulness practice is assigned as homework beginning with 5 minutes daily then advances to 20 minutes daily by final session.…”

Section: Interventionmentioning

confidence: 99%

Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxelbased Morphometry

Kurth

Lüders

Wu³

et al. 2014

Neuro Open J

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“…CBT-I is an effective nonpharmacological treatment that is most commonly used for insomnia. Many studies have shown that CBT-I can significantly improve sleep quality and reduce insomnia severity [13–15]. However, CBT-I is intensive, requiring administration by highly trained therapists [16].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Mind-Body Therapies on Insomnia: A Systematic Review and Meta-Analysis

Wang

Pan

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Background/Purpose. Sleep plays an important role in individuals’ health. The functions of the brain, the cardiovascular system, the immune system, and the metabolic system are closely associated with sleep. As a prevalent sleep disorder, insomnia has been closely concerned, and it is necessary to find effective therapies. In recent years, a growing body of studies has shown that mind-body therapies (MBTs) can improve sleep quality and ameliorate insomnia severity. However, a comprehensive and overall systematic review has not been conducted. In order to examine the effect of MBTs on insomnia, we conducted a systematic review and meta-analysis evaluating the effects of MBTs on sleep quality in healthy adults and clinical populations. Methods. PubMed, EMBASE, the Cochrane Library, and review of references were searched up to July 2018. English language studies of all designs evaluating the effect of MBTs on sleep outcomes in adults with or without diseases were examined. To calculate the SMDs and 95% CIs, we used a fixed effect model when heterogeneity was negligible and a random effect model when heterogeneity was significant. Results. 49 studies covering 4506 participants published between 2004 and 2018 were identified. Interventions included meditation, tai chi, qigong, and yoga which lasted 4 to 24 weeks. The MBTs resulted in statistically significant improvement in sleep quality and reduction on insomnia severity but no significant effects on sleep quantity indices, which were measured by sleep diary or objective measures. We analyzed the effects of tai chi and qigong separately as two different MBTs for the first time and found that qigong had a slight advantage over tai chi in the improvement of sleep quality. Subgroup analyses revealed that the effect of MBTs on sleep quality in healthy individuals was larger than clinical populations. The effect of MBTs might be influenced by the intervention duration but not the frequency. Conclusions. MBTs can be effective in treating insomnia and improving sleep quality for healthy individuals and clinical patients. More high-quality and well-controlled RCTs are needed to make a better conclusion in further study.

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“…However, pharmacological treatments for insomnia are associated with residual effects on awakening and during the daytime, tolerance and dependence 7 8. At the same time, CBT-I must be implemented by an experienced psychiatrist/psychologist with appropriate training 9. China has a large population, a high prevalence of insomnia and few qualified CBT-I psychiatrists/psychologists.…”

Section: Introductionmentioning

confidence: 99%

“…Nuclear factor kappa B (NF-κB) plays a key role in activation of inflammation in chronic insomnia 41. Interventions that improve sleep and reduce inflammation may have positive effects on the health of the general population 9…”

Section: Introductionmentioning

confidence: 99%

Efficacy of mindfulness-based intervention (‘mindfulness-based joyful sleep’) in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a prospective protocol of a randomised controlled trial in China

et al. 2019

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IntroductionInsomnia is a prevalent and significant public health concern. Insomnia can lead to increased inflammatory markers associated with chronic diseases such as cardiovascular disease, diabetes and cancer. Studies suggest that mindfulness-based interventions (MBIs) are more easily delivered within the community than cognitive behavioural therapy for insomnia (CBT-I) which was recommended as the preferred non-pharmacological treatment by the American Academy of Sleep Medicine, are effective in insomnia treatment and can reduce inflammatory markers level in older individuals with insomnia. This study aims to compare the effectiveness of an MBI to CBT-I in young and middle-aged individuals with insomnia disorder and explore its effect on nuclear factor kappa B (NF-κB), a transcription factor that controls the expression of genes involved in inflammation.Methods and analysisThis report describes a protocol for a randomised controlled trial. Seventy eligible participants will be assigned to mindfulness-based joyful sleep or CBT-I for 2-hour sessions weekly for 8 weeks. The primary outcome is sleep quality assessed by the Pittsburgh Sleep Quality Index, severity of insomnia symptoms assessed by the Insomnia Severity Index and sleep parameters recorded using sleep diary and polysomnography. Secondary outcomes include perceived stress, anxiety and depression. The exploratory outcome is serum level of NF-κB. Outcomes will be evaluated at baseline, the end of the ntervention period and at a 3 month follow-up. Data will be analysed using general linear models, specifically analysis of covariance and analysis of variance will be used.Ethics and disseminationFull ethical approval for this study has been obtained from the Ethics Committee of the Third Xiangya Hospital, Central South University, Changsha, China (2018-S236). If Mindfulness-Based Joyful Sleep is proven effective, its dissemination will help bridge the gap between the unmet need and the demand for insomnia interventions in China.Trial registration numberNCT03268629; Pre-results.

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Mindfulness-based intervention for prodromal sleep disturbances in older adults: Design and methodology of a randomized controlled trial

Cited by 18 publications

References 45 publications

Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxelbased Morphometry

Brain Gray Matter Changes Associated with Mindfulness Meditation in Older Adults: An Exploratory Pilot Study using Voxelbased Morphometry

The Effect of Mind-Body Therapies on Insomnia: A Systematic Review and Meta-Analysis

Efficacy of mindfulness-based intervention (‘mindfulness-based joyful sleep’) in young and middle-aged individuals with insomnia using a biomarker of inflammatory responses: a prospective protocol of a randomised controlled trial in China

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