Mind-wandering in Parkinson's disease hallucinations reflects primary visual and default network coupling

Walpola, Ishan C.; Muller, Alana J.; Hall, Julie M.; Andrews‐Hanna, Jessica R.; Irish, Muireann; Lewis, Simon J.G.; Shine, James M.; O’Callaghan, Claire

doi:10.1016/j.cortex.2019.12.023

Cited by 34 publications

(46 citation statements)

References 72 publications

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“…Comparable differences in connectivity have been reported in relation to autobiographical memory: Stronger resting state connectivity between the medial temporal lobes and visual cortices was seen in individuals reporting a more "episodic" style of autobiographical recollection, involving greater event detail, while individuals with a more factual style of recollection showed stronger connectivity between the medial temporal lobes and inferior and middle prefrontal regions (Sheldon et al 2016). In a related finding, among patients with Parkinson's disease, there is a stronger association between mind-wandering frequency and coupling between the default mode network and visual areas among patients with hallucinations as a manifestation of their disorder than among those who do not hallucinate (Walpola et al 2020). Our observation of stronger resting state coupling between both lateral and medial prefrontal regions and visual cortices among participants with hyperphantasia than among participants with aphantasia is potentially relevant both to the difference in their subjective experience of imagery and to the differences in performance we report on measures of autobiographical memory and imagination.…”

Section: Discussionmentioning

confidence: 92%

Behavioral and neural signatures of visual imagery vividness extremes: Aphantasia vs. Hyperphantasia

Milton¹,

Fulford²,

Dance³

et al. 2020

Preprint

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Although Galton recognised in 1880 that some individuals lack visual imagery, this phenomenon was largely neglected over the following century. We recently coined the terms ‘aphantasia’ and ‘hyperphantasia’ to describe visual imagery vividness extremes, unlocking a sustained surge of public interest. Aphantasia is associated with subjective impairment of face recognition and autobiographical memory. Here we report the first systematic, wide-ranging neuropsychological and brain imaging study of people with aphantasia (n=24), hyperphantasia (n=25) and mid-range imagery vividness (n=20). Despite equivalent performance on standard memory tests, there were marked group differences on measures of autobiographical memory and imagination, participants with hyperphantasia outperforming controls who outperformed participants with aphantasia. Face recognition difficulties were reported more commonly in aphantasia. The Revised NEO Personality Inventory highlighted reduced extroversion in the aphantasia group and increased openness in the hyperphantasia group. Resting-state fMRI revealed stronger connectivity between prefrontal cortices and the visual network among hyperphantasic than aphantasic participants. In an active fMRI paradigm, there was greater anterior parietal activation among hyperphantasic and control than aphantasic participants when comparing visualisation of famous faces and places with perception. These behavioral and neural signatures of visual imagery vividness extremes validate and illuminate this significant but neglected dimension of individual difference.

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Section: Discussionmentioning

confidence: 92%

Behavioral and neural signatures of visual imagery vividness extremes: Aphantasia vs. Hyperphantasia

Milton¹,

Fulford²,

Dance³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…2016 ). In a related finding, among patients with Parkinson’s disease, there is a stronger association between mind-wandering frequency and coupling between the default mode network and visual areas among patients with hallucinations as a manifestation of their disorder than among those who do not hallucinate ( Walpola et al. 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Neural Signatures of Visual Imagery Vividness Extremes: Aphantasia versus Hyperphantasia

Milton

Fulford

Dance

et al. 2021

Cerebral Cortex Communications

116

130

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Although Galton recognized in the 1880s that some individuals lack visual imagery, this phenomenon was mostly neglected over the following century. We recently coined the terms “aphantasia” and “hyperphantasia” to describe visual imagery vividness extremes, unlocking a sustained surge of public interest. Aphantasia is associated with subjective impairment of face recognition and autobiographical memory. Here we report the first systematic, wide-ranging neuropsychological and brain imaging study of people with aphantasia (n = 24), hyperphantasia (n = 25), and midrange imagery vividness (n = 20). Despite equivalent performance on standard memory tests, marked group differences were measured in autobiographical memory and imagination, participants with hyperphantasia outperforming controls who outperformed participants with aphantasia. Face recognition difficulties and autistic spectrum traits were reported more commonly in aphantasia. The Revised NEO Personality Inventory highlighted reduced extraversion in the aphantasia group and increased openness in the hyperphantasia group. Resting state fMRI revealed stronger connectivity between prefrontal cortices and the visual network among hyperphantasic than aphantasic participants. In an active fMRI paradigm, there was greater anterior parietal activation among hyperphantasic and control than aphantasic participants when comparing visualization of famous faces and places with perception. These behavioral and neural signatures of visual imagery vividness extremes validate and illuminate this significant but neglected dimension of individual difference.

show abstract

“…Relatedly, it has been reported that mind-wandering frequency in individuals with Parkinson’s disease who have hallucinatory experiences is strongly associated with the coupling between the primary visual cortex and dorsal default-mode network (Walpola et al, 2020). Is this an indication of more vivid (detailed) phenomenology?…”

Section: Future Directionsmentioning

confidence: 99%

Perceptual Representations and the Vividness of Stimulus-Triggered and Stimulus-Independent Experiences

Fazekas

Németh

Overgaard

2020

Perspect Psychol Sci

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In recent years, researchers from independent subfields have begun to engage with the idea that the same cortical regions that contribute to on-line perception are recruited during and underlie off-line activities such as information maintenance in working memory, mental imagery, hallucinations, dreaming, and mind wandering. Accumulating evidence suggests that in all of these cases the activity of posterior brain regions provides the contents of experiences. This article is intended to move one step further by exploring specific links between the vividness of experiences, which is a characteristic feature of consciousness regardless of its actual content, and certain properties of the content-specific neural-activity patterns. Investigating the mechanisms that underlie mental imagery and its relation to working memory and the processes responsible for mind wandering and its similarities to dreaming form two clusters of research that are in the forefront of the recent scientific study of mental phenomena, yet communication between these two clusters has been surprisingly sparse. Here our aim is to foster such information exchange by articulating a hypothesis about the fine-grained phenomenological structure determining subjective vividness and its possible neural basis that allows us to shed new light on these mental phenomena by bringing them under a common framework.

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Mind-wandering in Parkinson's disease hallucinations reflects primary visual and default network coupling

Cited by 34 publications

References 72 publications

Behavioral and neural signatures of visual imagery vividness extremes: Aphantasia vs. Hyperphantasia

Behavioral and neural signatures of visual imagery vividness extremes: Aphantasia vs. Hyperphantasia

Behavioral and Neural Signatures of Visual Imagery Vividness Extremes: Aphantasia versus Hyperphantasia

Perceptual Representations and the Vividness of Stimulus-Triggered and Stimulus-Independent Experiences

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