“…Some studies have focused on improving registration accuracy by considering the use of additional image gradient information (Pluim et al, 2000a,b), neighbor pixel information (Heinrich et al, 2012b;Kybic and Vnucko, 2012;Rueckert et al, 2000), textural information (Heinrich et al, 2012a), or different approaches to weighted MI (Park et al, 2010;Rodriguez-Carranza and Loew, 1999;Van Dalen et al, 2004). One approach to weighted MI is the regularization of MI with the use of weights based on overlaps (Rodriguez-Carranza and Loew, 1999) without including spatial information.…”