Mind-Body Training for At - Risk Populations:  Preventive Medicine at its Best

Elder, Charles

doi:10.7812/tpp/16-174

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…Le Roy et al7PembrolizumabMelanoma2Case ACase BImmune thrombocytopeniaA: 1st cycleB: NAA: steroids and intravenousinfusions of immunoglobulins (IVIG).B: A course of steroidA: EffectiveB: EffectiveT. Samer et al8NivolumabNSCLC1Severe agranulocytosis2nd cycleIVIG plus oral and IV steroidsEffectiveNair R, et al9PembrolizumabMelanoma1Warm-antibody autoimmune hemolytic anemia and pure red-cell aplasia3rd cycleHigh-dose steroidsPure red-cell aplasia flared when prednisone tapered to 20 mg.Subsequent treatment with one dose of IVIG enabled tapering of the glucocorticoidsAtwal, Dinesh, et al10PembrolizumabMelanoma1Pancytopenia18th cycleHigh-dose prednisolone and a 5-day course of IVIGResolved after IVIG courseJ.-M. Michot et al11NivolumabStage IV adenocarcinoma of the lung3Case ACase BCase CBone marrow failure as an immune-related aplastic anemiaNAA: IGIV, Antibiotics,4 RBC units + 3 platelets unitsB: Steroids, GCSF, 4 RBC and9 platelets unitsC: Steroids, IGIV, GCSF,antibiotics, 20 RBCand 15 platelets unitsA: ineffectiveB: Partial and transientresponse to steroids;persistent pancytopeniastill ongoing at 4 monthsC: ineffective. Abbreviations: ICPIs, immune checkpoint inhibitors; IVIG, intravenous immunoglobulin; GCSF, granulocyte colony-stimulating factor; RBC, red blood cells; NA, not available; ITP, Idiopathic thrombocytopenic purpura.…”

Section: Discussionmentioning

confidence: 99%

“…To date, hematological immune-related adverse events remain occasionally described;5 for instance, bi-cytopenia (severe anemia and thrombocytopenia) possibly induced after the sixth cycle of injection of Nivolumab (anti-PD-1 antibody), given to a patient with primary malignant melanoma of the esophagus with inefficiency of high-dose intravenous methylprednisolone,6 immune-mediated thrombocytopenia,7 immune-mediated agranulocytosis,8 immunotherapy-associated hemolytic anemia with pure red-cell aplasia,9 immune medicated pancytopenia,10 and even central immune cytopenia 11…”

Section: Introductionmentioning

confidence: 99%

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<p>Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)</p>

Kanbour¹,

Rasul²,

Al-Bader³

et al. 2019

OTT

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BackgroundClear cell carcinoma of the endometrium (CCE) has a tendency to occur in a mismatch repair protein deficient molecular background. Treatment with immunotherapy can predict a favorable response.Case presentationWe are presenting a 53-year-old female, diagnosed with CCE 17 years ago, who was treated initially with hysterectomy and left salpingo-oophorectomy, who relapsed a few months later, and was then treated with left pelvic mass excision and sigmoidectomy. Recently, the disease recurred as a retroperitoneal lymphadenopathy, which was resected but then relapsed locally, spread to the lungs, and progressed further after three lines of chemotherapy. On pathological review of the tumor, it was found to harbor loss of nuclear expression of MLH-1 and PMS-2. Based on a strong predictor of response to immunotherapy, pembrolizumab was tried. However, within a few days of the single dose of pembrolizumab, immune thrombocytopenia followed by pancytopenia, recurrent seizures, visual hallucination, and cerebellar signs consistent with limbic encephalitis developed, which were not responding to steroid and intravenous immunoglobulin.ConclusionWe are presenting a case of a CCE with deficient mismatch repair that developed two autoimmune side effects, pancytopenia and limbic encephalitis, within a few days of a single injection of pembrolizumab.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)</p>

Kanbour¹,

Rasul²,

Al-Bader³

et al. 2019

OTT

View full text Add to dashboard Cite

show abstract

“…However, preventive medicine entails actions that guard against disease occurrence, which involves actions targeted at eliminating or supressing the impact of disease, or if not attainable, delaying the progress of disease [ 1 ]. Preventive medicine can be observed today in the promotion of vaccination to guard against the spread of infectious diseases [ 2 ]. Historically, healthcare has been skewed towards curative medicine neglecting preventive care leading to high cases of preventable diseases and mortalities.…”

mentioning

confidence: 99%