Mimotope mimicking epidermal growth factor receptor alleviates mononuclear cell infiltration in exocrine glands induced by muscarinic acetylcholine 3 receptor

Yang, Lin; Wang, Yongfu; Xing, Rui; Bai, Li; Li, Changhong; Li, Zhengqian; Lei, Yu

doi:10.1016/j.clim.2016.01.006

Cited by 7 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their investigation of EGFR signaling and Fas-mediated apoptosis, Yang et al reported a relationship between muscarinic type 3 receptor (M3R) and EGFR in association with an apoptotic pathway mediated by the Fas/FasL system [134]. Although M3R is a one of the major autoantigens in SS [135], recombinant M3R peptide induces murine sialadenitis with M3R-reactive T-cell expansion, and a retinoic acid-related orphan receptor-gamma t (RORγt) antagonist can inhibit SS-like sialadenitis [136].…”

Section: Control Of Apoptosis In Sjögren’s Syndromementioning

confidence: 99%

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Nakamura

Horai

Shimizu

et al. 2018

IJMS

View full text Add to dashboard Cite

The pathogenesis of Sjögren’s syndrome (SS) involves multiple factors including genetic background, cell death, and exocrine dysfunction. We here discuss apoptotic control in exocrine glands in SS by showing various pro- and anti-apoptotic pathways. Although the membrane-bound and soluble form of the Fas/Fas ligand system is a leading player with activation of the death domain and caspase 8/3 cleavage, the role of soluble Fas/FasL (including its polymorphism) in apoptosis is controversial. The tumor necrosis factor related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of salivary gland epithelial cells (SGECs) involves a mitochondrial pathway that includes caspase 9 cleavage. The involvement of innate immunity cells such as toll-like receptors (TLRs) has been investigated; TLR2-4 and TLR7-9 are associated with the induction of inflammation in exocrine glands of SS patients. TLR3 has the potential to induce the apoptosis of SS patients’ SGECs. Linkage of epidermal growth factor (EGF) was shown in exocrine glands in SS, and it inhibited the Fas/FasL system with the help of cell-survival factors. TLR3 has dual actions to cause inflammation as well as apoptosis, which are inhibited by EGF. In conclusion, apoptosis in exocrine glands of SS patients is tightly controlled by balance of pro-apoptotic signals and growth factor.

show abstract

Section: Control Of Apoptosis In Sjögren’s Syndromementioning

confidence: 99%

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Nakamura

Horai

Shimizu

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Yang et al 27 described an interesting model of Sjögren’s syndrome in mice induced by immunization of a mixture of peptides derived from extracellular loops of M3R. These mice displayed features of inflammation in the lacrimal glands, salivary glands and the intestines.…”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

“…IFN-γ may have increased the activation of MNCs or reduced the apoptosis of MNCs, and either scenario would explain the greater infiltration of MNCs into the lacrimal gland. 27 …”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

“…Since IL-17 normally stimulates MNC proliferation, this may also explain the reduction of MNCs in the lacrimal glands. 27 …”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

“…The beneficial effects of less immune cell infiltration into the salivary glands may be partly obliterated by the detrimental effect of the cross-reacting antibodies blocking M3R signaling for saliva production. 27 …”

Section: Muscarinic Receptors As Autoantigens In Sjögren’s Syndromementioning

confidence: 99%

See 2 more Smart Citations

Review of autoantigens in Sjögren’s syndrome: an update

Tong¹,

Koh²,

Thong³

2017

JIR

View full text Add to dashboard Cite

Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by inflammation in exocrine glands, resulting in reduced secretion of tears and saliva, manifesting as xerophthalmia and xerostomia, respectively. It is commonly associated with Sjögren’s syndrome type A (Ro) and Sjögren’s syndrome type B (La) antigens. However, in most patients, the identity of the triggering antigen is not known. Factors such as genetics of histocompatibility, dysregulation of T-cells, B-cells and viral infections have been implicated. Several important studies on autoantigens in pSS have been published since a review in 2012, and the aim of this review is to provide an update on further peer-reviewed original articles in this field. Oxidative damage of Ro60 antigen may explain the epitope spreading during the immune activation in pSS. Immune-mediated destruction of the muscarinic receptor-3-expressing cells has been associated with a reduction in parasympathetic function, which could cause reduced secretory function of exocrine glands. Such a process also activates reactive oxidative species and antioxidants, which are linked to the triggering of inflammatory responses. Elevated levels of kallikrein, yet another antigen present in the lacrimal gland and other tissues, are similarly involved in triggering an autoimmune T-cell response against target glands. Studying additional antigens, the platelet-selectin and vasoactive intestinal peptides, in patients with pSS can help to elucidate the origin and process of autoimmunity, or even lead to potential biomarkers. In conclusion, the understanding of autoantigens has led to exciting major advances in the biology of pSS and may influence diagnosis and management of pSS in future.

show abstract

Mechanisms of Secretory Dysfunction in Autoimmune Sjögren’s Syndrome

Saleh

Singh

Katz

et al. 2021

Sjögren's Syndrome and Oral Health

View full text Add to dashboard Cite

Mimotope mimicking epidermal growth factor receptor alleviates mononuclear cell infiltration in exocrine glands induced by muscarinic acetylcholine 3 receptor

Cited by 7 publications

References 45 publications

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Review of autoantigens in Sjögren’s syndrome: an update

Mechanisms of Secretory Dysfunction in Autoimmune Sjögren’s Syndrome

Contact Info

Product

Resources

About

Mimotope mimicking epidermal growth factor receptor alleviates mononuclear cell infiltration in exocrine glands induced by muscarinic acetylcholine 3 receptor

Cited by 7 publications

References 45 publications

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren’s Syndrome

Review of autoantigens in Sj&ouml;gren&rsquo;s syndrome: an update

Mechanisms of Secretory Dysfunction in Autoimmune Sjögren’s Syndrome

Contact Info

Product

Resources

About

Review of autoantigens in Sjögren’s syndrome: an update