Abstract-Analyzing health conditions using sensors is one of the daily activities in a healthcare organization. The purpose of this research is to improve the e-healthcare formulated through the integration of wearable smart sensors and miniaturized devices. In this research, monitoring glucose level of the diabetic is considered as an example of the non-linear problem in which we show that accuracy and efficiency of e-healthcare can be achieved through Multiple-input, multiple-output (MIMO) system. In this novel technique, Pn-manifolds, which are the nonlinear mathematical approach, provide the flexible rate and enhance the accuracy and efficiency of the medical systems in the e-healthcare services.