Mimivirus-Encoded Nucleotide Translocator VMC1 Targets the Mitochondrial Inner Membrane

Zara, Vincenzo; Ferramosca, Alessandra; Günnewig, Kathrin; Kreimendahl, Sebastian; Schwichtenberg, Jan; Sträter, Dina; Çakar, Mahmut; Emmrich, Kerstin; Guidato, Patrick M.; Palmieri, Ferdinando; Rassow, Joachim

doi:10.1016/j.jmb.2018.09.012

Cited by 6 publications

(9 citation statements)

References 78 publications

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“…Analyses of sequences of RNA polymerases independently confirm the phage–mitochondria relationships . This suggests that the presence of similar polymerases likely reflects phylogenetic relatedness rather than more or less coincidental lateral transfers as could be inferred from the presence of homologs of mitochondrial membrane proteins in genomes of giant viruses …”

Section: Introductionmentioning

confidence: 75%

“…The amoeban mitochondrial inner membrane is the specific target of a membrane-bound protein coded by mimivirus. 39 This stresses that virus factories are in the immediate vicinity of mitochondria. 40,41 Further evidence goes beyond colocalization and functional relationships.…”

Section: Cellular Origin Of Virusesmentioning

confidence: 99%

“…57,58 This suggests that the presence of similar polymerases likely reflects phylogenetic relatedness rather than more or less coincidental lateral transfers as could be inferred from the presence of homologs of mitochondrial membrane proteins in genomes of giant viruses. 39 Moreover, the morphogenesis of poxviral particles includes cell-like phases involving the formation of cell compartments 2,38 with double membranes in some species, 37 as in mitochondria. This leads to the hypothesis that viruses evolved from bacterial endospores.…”

Section: Cellular Origin Of Virusesmentioning

confidence: 99%

“…Several observations suggest unexpected links between mitochondria and giant viruses. The amoeban mitochondrial inner membrane is the specific target of a membrane‐bound protein coded by mimivirus . This stresses that virus factories are in the immediate vicinity of mitochondria .…”

Section: Introductionmentioning

confidence: 99%

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Giant viruses: spore‐like missing links between Rickettsia and mitochondria?

Seligmann

2019

Annals of the New York Academy of Sciences

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Phyloproteomics indicate common viral origin from ancient cells before archaea, bacteria, and eukaryota split and subsequent size and complexity reductions occurred. Further independent evidence for the cellular origin of viruses is reviewed for the virus order Megavirales, focusing on the family Poxviridae. Megavirales comprises giant viruses, double‐stranded DNA viruses whose genomes exceed some bacterial ones and large enough to parasitize large‐celled protists (amoeba). Giant viruses, virophages, and mitochondria have homologous DNA and RNA polymerases and share RNA splicing punctuation by stem–loop hairpins. Giant virus factories and amoeban mitochondria colocate, with viral proteins homologous to mitochondrial proteins specifically targeting mitochondrial inner membranes. Mitochondria share asexual budding with many bacterial endospores and membrane‐enveloped viruses. These megavirus−mitochondrion similarities are not coincidental: systematic alignment analyses have detected candidate megaviral homologs of each amoeban mitogene (including ribosomal RNAs) distributed across megaviral genomes. These candidate megaviral homologs overall follow mitogene order, and megaviral−mitogenome synteny increases with viral genome reduction. This analysis is repeated within Poxviridae, whose organellar‐like morphogenesis is reminiscent of mitochondria. More generally, the results confirm the patterns observed in Megavirales: synteny with amoeban mitogenomes increases with genome reduction. Parsimoniously interpreting this suggests Megavirales and mitochondria have a rickettsia‐like common ancestor. Megavirales could be the missing links between bacterial‐like cells and mitochondria, implying cellular‐to‐viral‐to‐subcellular macroevolution.

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Section: Introductionmentioning

confidence: 75%

Section: Cellular Origin Of Virusesmentioning

confidence: 99%

Section: Cellular Origin Of Virusesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Giant viruses: spore‐like missing links between Rickettsia and mitochondria?

Seligmann

2019

Annals of the New York Academy of Sciences

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“…A Mimivirus protein coding gene produces a homolog of an amoeban inner mitochondrial membrane transporter that targets inner mitochondrial membranes (Zara et al, 2018). This specific case might reflect an occasional, putatively adaptive horizontal gene transfer from the amoeban mitochondrion to its endocellular parasite, Mimivirus.…”

Section: Gene Homologies In Mitochondrial and Megaviral Genomesmentioning

confidence: 99%

Syntenies Between Cohosted Mitochondrial, Chloroplast, and Phycodnavirus Genomes: Functional Mimicry and/or Common Ancestry?

Seligmann

2019

DNA and Cell Biology

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Recent analyses suggest bacterial and/or mitochondrion-like ancestry for giant viruses (Megavirales sensu latu): amoeban mitochondrial gene arrangements resemble those of their candidate homologs in megaviral genomes. This presumed ancestral synteny decreases with genome size across megaviral families at large and within Poxviridae. In this study, analyses focus on Phycodnaviridae, a polyphyletic group of giant viruses infecting Haplophyta, Stramenopiles, and other algae, using syntenies between algal mitogene arrangements and chloroplast genomes and Rickettsia prowazekii as positive controls. Mitogene alignment qualities with Rickettsia are much higher than with viral genomes. Mitogenome synteny with some viruses is higher, for others lower than with Rickettsia, despite lower alignments qualities. In some algae, syntenies among cohosted chloroplast, virus, and mitochondrion are higher, in others lower than expected. This suggests gene order coevolution in cohosted genomes, different coregulations of organelle metabolisms for different algae, and viral mitogenome mimicry, to hijack organelle-committed cellular resources and/or escape cellular defenses/genetic immunity systems. This principle might explain high synteny between human mitochondria and the pathogenic endocellular alphaproteobacterium R. prowazekii beyond common ancestry. Results indicate that putative bacteria/mitochondrion-like genomic ancestors of Phycodnaviridae originated before or at the mitochondrionbacteria split, and ulterior functional constraints on gene arrangements of cohosted genomes.

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Contribution of yeast models to virus research

Glingston

Yadav

Rajpoot

et al. 2021

Appl Microbiol Biotechnol

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Time and again, yeast has proven to be a vital model system to understand various crucial basic biology questions. Studies related to viruses are no exception to this. This simple eukaryotic organism is an invaluable model for studying fundamental cellular processes altered in the host cell due to viral infection or expression of viral proteins. Mechanisms of infection of several RNA and relatively few DNA viruses have been studied in yeast to date. Yeast is used for studying several aspects related to the replication of a virus, such as localization of viral proteins, interaction with host proteins, cellular effects on the host, etc. The development of novel techniques based on high-throughput analysis of libraries, availability of toolboxes for genetic manipulation, and a compact genome makes yeast a good choice for such studies. In this review, we provide an overview of the studies that have used yeast as a model system and have advanced our understanding of several important viruses. Key points• Yeast, a simple eukaryote, is an important model organism for studies related to viruses.• Several aspects of both DNA and RNA viruses of plants and animals are investigated using the yeast model.• Apart from the insights obtained on virus biology, yeast is also extensively used for antiviral development.

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Mimivirus-Encoded Nucleotide Translocator VMC1 Targets the Mitochondrial Inner Membrane

Cited by 6 publications

References 78 publications

Giant viruses: spore‐like missing links between Rickettsia and mitochondria?

Giant viruses: spore‐like missing links between Rickettsia and mitochondria?

Syntenies Between Cohosted Mitochondrial, Chloroplast, and Phycodnavirus Genomes: Functional Mimicry and/or Common Ancestry?

Contribution of yeast models to virus research

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