Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds

Hernandez-Gordillo, Victor; Chmielewski, Jean

doi:10.1016/j.biomaterials.2014.05.019

Cited by 68 publications

(66 citation statements)

References 80 publications

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“…Recently, the same group incorporated the RGDS adhesion sequences as well as His-tagged growth factors (His-EGF) to promote bioactivity into their scaffold. 25 …”

Section: Current Peptide-based Scaffoldsmentioning

confidence: 99%

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

et al. 2014

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In an effort to develop bioactive matrices for regenerative medicine, peptides have been used widely to promote interactions with cells and elicit desired behaviors in vivo. This paper describes strategies that utilize peptide-based molecules as building blocks to create supramolecular nanostructures that emulate not only the architecture but also the chemistry of the extracellular matrix in mammalian biology. After initiating a desired regenerative response in vivo, the innate biodegradability of these systems allow for the natural biological processes to take over in order to promote formation of a new tissue without leaving a trace of the nonnatural components. These bioactive matrices can either bind or mimic growth factors or other protein ligands to elicit a cellular response, promote specific mechanobiological responses, and also guide the migration of cells with programmed directionality. In vivo applications discussed in this review using peptide-based matrices include the regeneration of axons after spinal cord injury, regeneration of bone, and the formation of blood vessels in ischemic muscle as a therapy in peripheral arterial disease and cardiovascular diseases.

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“…Recently, the same group incorporated the RGDS adhesion sequences as well as His-tagged growth factors (His-EGF) to promote bioactivity into their scaffold. 25 …”

Section: Current Peptide-based Scaffoldsmentioning

confidence: 99%

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

et al. 2014

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“…Importantly, this has also led to the development of new bio-inspired configurations that mimic the naturally occurring architectures while maintaining their functional properties, or even give rise to new functionalities. Prime examples of this approach are amyloid-like assemblies formed by peptide sequences that were identified as core recognition modules of amyloidogenic proteins12345, superhelical and coiled coil fibres based on heptad repeats as inspired by intermediate filaments and keratin6789, and collagen-like assemblies based on the characteristic collagen repeating sequence1011. While such common protein polymers have been investigated and mimicked, similar study of the bacterial type IV pilus (T4P), an abundant class of polymeric nanofibres, has been very limited.…”

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confidence: 99%

Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

et al. 2016

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Mimicking the multifunctional bacterial type IV pili (T4Ps) nanofibres provides an important avenue towards the development of new functional nanostructured biomaterials. Yet, the development of T4Ps-based applications is limited by the inability to form these nanofibres in vitro from their pilin monomers. Here, to overcome this limitation, we followed a reductionist approach and designed a self-assembling pilin-based 20-mer peptide, derived from the presumably bioelectronic pilin of Geobacter sulfurreducens. The designed 20-mer, which spans sequences from both the polymerization domain and the functionality region of the pilin, self-assembled into ordered nanofibres. Investigation of the 20-mer revealed that shorter sequences which correspond to the polymerization domain form a supramolecular β-sheet, contrary to their helical configuration in the native T4P core, due to alternative molecular recognition. In contrast, the sequence derived from the functionality region maintains a native-like, helical conformation. This study presents a new family of self-assembling peptides which form T4P-like nanostructures.

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“…However, the mechanical properties of the resulting gels have not been determined. Bioactive sequences can be coupled covalently to promote cell adhesion [98]. By functionalization of growth factors with a His tag, these growth factors can also be supramolecularly complexed to the matrix using nickel ions.…”

Section: Hybrid Supramolecular Hydrogel Systemsmentioning

confidence: 99%

Supramolecular Hydrogels for Regenerative Medicine

Pape

Dankers

2015

Supramolecular Polymer Networks and Gels

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Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds

Cited by 68 publications

References 80 publications

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

Formation of bacterial pilus-like nanofibres by designed minimalistic self-assembling peptides

Supramolecular Hydrogels for Regenerative Medicine

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